Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for HSF2
Z-value: 0.79
Motif logo
Transcription factors associated with HSF2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HSF2 | hg38_v1_chr6_+_122399536_122399568, hg38_v1_chr6_+_122399621_122399692 | 0.07 | 2.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HSF2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 28.9 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.3 | 24.3 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 5.1 | 20.5 | GO:0099640 | axo-dendritic protein transport(GO:0099640) |
| 0.6 | 17.5 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 1.9 | 15.4 | GO:0003433 | chondrocyte development involved in endochondral bone morphogenesis(GO:0003433) |
| 0.1 | 15.0 | GO:0007498 | mesoderm development(GO:0007498) |
| 0.4 | 11.7 | GO:0036120 | cellular response to platelet-derived growth factor stimulus(GO:0036120) |
| 0.1 | 9.8 | GO:1900034 | regulation of cellular response to heat(GO:1900034) |
| 0.8 | 9.5 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 1.0 | 9.4 | GO:1903748 | negative regulation of establishment of protein localization to mitochondrion(GO:1903748) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 46.0 | GO:0005925 | focal adhesion(GO:0005925) |
| 1.8 | 28.9 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.3 | 20.5 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.1 | 17.8 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.5 | 17.5 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 0.0 | 11.6 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 9.2 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 8.7 | GO:0030018 | Z disc(GO:0030018) |
| 0.2 | 8.5 | GO:0016235 | aggresome(GO:0016235) |
| 0.6 | 8.1 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 36.3 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 1.0 | 28.9 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 23.9 | GO:0044325 | ion channel binding(GO:0044325) |
| 6.8 | 20.5 | GO:0008426 | protein kinase C inhibitor activity(GO:0008426) |
| 1.5 | 16.4 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 0.2 | 11.7 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.3 | 10.4 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.5 | 9.5 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.1 | 8.7 | GO:0005518 | collagen binding(GO:0005518) |
| 1.3 | 8.0 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 20.5 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 15.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 11.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 11.7 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.2 | 10.3 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 8.7 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.2 | 8.0 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 6.0 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 5.8 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 4.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 27.8 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.3 | 17.0 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.7 | 11.7 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.2 | 10.4 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.3 | 8.8 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.1 | 8.0 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.5 | 5.5 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.2 | 5.4 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 5.3 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.1 | 5.0 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |