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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HSFY2
Z-value: 1.18
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Transcription factors associated with HSFY2
Network of associatons between targets according to the STRING database.
First level regulatory network of HSFY2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_31739260 Show fit | 29.62 |
ENST00000340513.4
ENST00000300403.11 |
TPX2 microtubule nucleation factor |
|
| chr2_-_168913277 Show fit | 27.76 |
ENST00000451987.5
|
SPC25 component of NDC80 kinetochore complex |
|
| chr3_-_185923893 Show fit | 26.71 |
ENST00000259043.11
|
transformer 2 beta homolog |
|
| chr1_-_150234668 Show fit | 26.20 |
ENST00000616917.4
|
acidic nuclear phosphoprotein 32 family member E |
|
| chr1_-_197146620 Show fit | 25.10 |
ENST00000367409.9
ENST00000680265.1 |
assembly factor for spindle microtubules |
|
| chr1_-_197146688 Show fit | 24.99 |
ENST00000294732.11
|
assembly factor for spindle microtubules |
|
| chr15_+_41286011 Show fit | 24.88 |
ENST00000661438.1
|
novel protein |
|
| chr4_-_99950262 Show fit | 22.78 |
ENST00000296417.6
ENST00000651623.1 |
H2A.Z variant histone 1 |
|
| chr21_-_39349048 Show fit | 22.69 |
ENST00000380748.5
ENST00000380749.10 |
high mobility group nucleosome binding domain 1 |
|
| chr2_+_27212866 Show fit | 21.94 |
ENST00000419744.1
|
all-trans retinoic acid induced differentiation factor |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 16.7 | 50.1 | GO:0009786 | regulation of asymmetric cell division(GO:0009786) |
| 16.5 | 49.5 | GO:0097698 | telomere maintenance via base-excision repair(GO:0097698) |
| 0.5 | 45.5 | GO:0090114 | COPII-coated vesicle budding(GO:0090114) |
| 0.4 | 43.3 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 1.4 | 38.3 | GO:0006465 | signal peptide processing(GO:0006465) |
| 1.0 | 35.9 | GO:0032786 | positive regulation of DNA-templated transcription, elongation(GO:0032786) |
| 4.4 | 35.1 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 0.6 | 35.0 | GO:0043486 | histone exchange(GO:0043486) |
| 0.6 | 33.5 | GO:0043277 | apoptotic cell clearance(GO:0043277) |
| 0.6 | 31.0 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 79.1 | GO:0005730 | nucleolus(GO:0005730) |
| 0.5 | 56.9 | GO:0000784 | nuclear chromosome, telomeric region(GO:0000784) |
| 5.6 | 50.1 | GO:0036449 | microtubule minus-end(GO:0036449) meiotic spindle(GO:0072687) |
| 1.6 | 47.6 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.1 | 40.2 | GO:1990904 | ribonucleoprotein complex(GO:1990904) |
| 2.6 | 38.4 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 4.3 | 38.3 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 3.0 | 29.6 | GO:0043203 | axon hillock(GO:0043203) |
| 0.6 | 28.8 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.9 | 27.9 | GO:0031143 | pseudopodium(GO:0031143) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 63.7 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 12.4 | 49.5 | GO:0008311 | double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311) |
| 0.2 | 41.9 | GO:0005516 | calmodulin binding(GO:0005516) |
| 1.9 | 38.4 | GO:0015037 | peptide disulfide oxidoreductase activity(GO:0015037) |
| 2.2 | 35.1 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.8 | 33.6 | GO:0019956 | chemokine binding(GO:0019956) |
| 0.2 | 33.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.6 | 32.4 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.5 | 30.4 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 6.0 | 29.8 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 45.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.0 | 43.7 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.6 | 30.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.6 | 27.2 | PID ALK1 PATHWAY | ALK1 signaling events |
| 1.0 | 25.8 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.2 | 17.4 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.2 | 16.0 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.6 | 14.9 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.3 | 13.6 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.3 | 13.5 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 53.4 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.6 | 44.5 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.6 | 44.0 | REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT | Genes involved in p53-Independent G1/S DNA damage checkpoint |
| 2.2 | 42.7 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.2 | 33.6 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.9 | 33.1 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.4 | 31.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.0 | 28.5 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.9 | 26.5 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.6 | 26.3 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |