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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HSFY2
Z-value: 1.18
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Transcription factors associated with HSFY2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
HSFY2
|
ENSG00000169953.12 | HSFY2 |
Activity profile of HSFY2 motif
Sorted Z-values of HSFY2 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of HSFY2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 16.7 | 50.1 | GO:0009786 | regulation of asymmetric cell division(GO:0009786) |
| 16.5 | 49.5 | GO:0097698 | telomere maintenance via base-excision repair(GO:0097698) |
| 9.2 | 27.5 | GO:0005999 | xylulose biosynthetic process(GO:0005999) |
| 7.4 | 22.1 | GO:0018160 | peptidyl-pyrromethane cofactor linkage(GO:0018160) |
| 6.9 | 20.7 | GO:1903778 | positive regulation of histamine secretion by mast cell(GO:1903595) protein localization to vacuolar membrane(GO:1903778) |
| 5.4 | 16.1 | GO:1990022 | RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022) |
| 5.3 | 16.0 | GO:0097252 | oligodendrocyte apoptotic process(GO:0097252) |
| 5.1 | 20.3 | GO:1903609 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 4.7 | 14.0 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
| 4.4 | 35.1 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 4.4 | 26.2 | GO:0097052 | L-kynurenine metabolic process(GO:0097052) |
| 3.9 | 19.7 | GO:0051792 | medium-chain fatty acid biosynthetic process(GO:0051792) |
| 3.7 | 11.0 | GO:0046081 | dUTP metabolic process(GO:0046080) dUTP catabolic process(GO:0046081) |
| 3.5 | 17.6 | GO:0044111 | development involved in symbiotic interaction(GO:0044111) |
| 3.1 | 12.3 | GO:0000912 | assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837) |
| 3.1 | 12.3 | GO:0035880 | embryonic nail plate morphogenesis(GO:0035880) |
| 3.1 | 18.4 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 3.0 | 11.9 | GO:1904569 | regulation of selenocysteine incorporation(GO:1904569) |
| 2.7 | 8.2 | GO:0035928 | rRNA import into mitochondrion(GO:0035928) |
| 2.6 | 20.5 | GO:0035694 | mitochondrial protein catabolic process(GO:0035694) |
| 2.5 | 15.1 | GO:0070101 | epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) positive regulation of chemokine-mediated signaling pathway(GO:0070101) |
| 2.5 | 7.4 | GO:1904387 | response to human chorionic gonadotropin(GO:0044752) cellular response to thyroxine stimulus(GO:0097069) cellular response to L-phenylalanine derivative(GO:1904387) |
| 2.4 | 7.2 | GO:1902568 | positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568) |
| 2.3 | 7.0 | GO:0060957 | endocardial cell fate commitment(GO:0060957) endocardial cushion cell fate commitment(GO:0061445) |
| 2.3 | 13.6 | GO:0019060 | intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708) |
| 2.1 | 14.9 | GO:0097680 | double-strand break repair via classical nonhomologous end joining(GO:0097680) |
| 2.1 | 10.4 | GO:0040030 | regulation of molecular function, epigenetic(GO:0040030) |
| 2.1 | 6.2 | GO:0001189 | RNA polymerase I transcriptional preinitiation complex assembly(GO:0001188) RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript(GO:0001189) |
| 2.1 | 26.7 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 2.0 | 8.0 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
| 2.0 | 17.8 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 2.0 | 5.9 | GO:0044205 | 'de novo' UMP biosynthetic process(GO:0044205) |
| 1.8 | 16.0 | GO:1902459 | positive regulation of stem cell population maintenance(GO:1902459) |
| 1.7 | 6.9 | GO:1904116 | traversing start control point of mitotic cell cycle(GO:0007089) response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117) |
| 1.7 | 5.1 | GO:1903487 | regulation of lactation(GO:1903487) |
| 1.6 | 16.3 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) |
| 1.6 | 17.5 | GO:0090343 | positive regulation of cell aging(GO:0090343) positive regulation of cellular senescence(GO:2000774) |
| 1.6 | 18.9 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
| 1.5 | 4.4 | GO:0014016 | neuroblast differentiation(GO:0014016) |
| 1.5 | 4.4 | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone(GO:0006121) |
| 1.4 | 7.0 | GO:2000645 | negative regulation of receptor catabolic process(GO:2000645) |
| 1.4 | 11.0 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146) |
| 1.4 | 12.3 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 1.4 | 38.3 | GO:0006465 | signal peptide processing(GO:0006465) |
| 1.3 | 6.6 | GO:0070433 | negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433) |
| 1.3 | 3.9 | GO:0044565 | dendritic cell proliferation(GO:0044565) |
| 1.3 | 5.2 | GO:0035407 | regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage(GO:0010767) histone H3-T11 phosphorylation(GO:0035407) |
| 1.3 | 7.6 | GO:0046086 | AMP catabolic process(GO:0006196) adenosine biosynthetic process(GO:0046086) |
| 1.2 | 8.5 | GO:0008215 | spermine metabolic process(GO:0008215) spermidine biosynthetic process(GO:0008295) |
| 1.2 | 3.5 | GO:0060152 | peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152) |
| 1.1 | 3.4 | GO:0070407 | oxidation-dependent protein catabolic process(GO:0070407) |
| 1.1 | 3.3 | GO:0009183 | purine deoxyribonucleotide biosynthetic process(GO:0009153) purine deoxyribonucleoside diphosphate biosynthetic process(GO:0009183) dGDP metabolic process(GO:0046066) |
| 1.1 | 15.2 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 1.1 | 5.3 | GO:0072396 | response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423) |
| 1.0 | 7.3 | GO:0010917 | negative regulation of mitochondrial membrane potential(GO:0010917) |
| 1.0 | 9.0 | GO:0032790 | ribosome disassembly(GO:0032790) |
| 1.0 | 7.0 | GO:0032328 | alanine transport(GO:0032328) |
| 1.0 | 35.9 | GO:0032786 | positive regulation of DNA-templated transcription, elongation(GO:0032786) |
| 0.9 | 5.6 | GO:0032468 | Golgi calcium ion homeostasis(GO:0032468) |
| 0.9 | 2.8 | GO:0071034 | CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) |
| 0.9 | 21.9 | GO:0033689 | negative regulation of osteoblast proliferation(GO:0033689) |
| 0.9 | 9.5 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
| 0.8 | 3.3 | GO:1903756 | regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758) |
| 0.8 | 9.9 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.8 | 9.0 | GO:0014067 | negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067) |
| 0.8 | 13.9 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 0.8 | 2.4 | GO:0050717 | positive regulation of interleukin-1 alpha secretion(GO:0050717) |
| 0.8 | 4.7 | GO:0042997 | negative regulation of low-density lipoprotein particle clearance(GO:0010989) negative regulation of Golgi to plasma membrane protein transport(GO:0042997) |
| 0.8 | 4.7 | GO:0019509 | L-methionine biosynthetic process from methylthioadenosine(GO:0019509) |
| 0.7 | 4.9 | GO:0030423 | targeting of mRNA for destruction involved in RNA interference(GO:0030423) |
| 0.7 | 2.8 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944) |
| 0.7 | 7.7 | GO:2000795 | trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.7 | 3.4 | GO:0019747 | regulation of isoprenoid metabolic process(GO:0019747) |
| 0.7 | 13.4 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.7 | 3.3 | GO:0030070 | insulin processing(GO:0030070) |
| 0.6 | 31.0 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
| 0.6 | 6.3 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.6 | 35.0 | GO:0043486 | histone exchange(GO:0043486) |
| 0.6 | 25.0 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.6 | 1.8 | GO:1990426 | homologous recombination-dependent replication fork processing(GO:1990426) |
| 0.6 | 3.0 | GO:1902513 | regulation of organelle transport along microtubule(GO:1902513) |
| 0.6 | 33.5 | GO:0043277 | apoptotic cell clearance(GO:0043277) |
| 0.6 | 2.4 | GO:0071395 | response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395) |
| 0.6 | 0.6 | GO:0002585 | positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) positive regulation of antigen processing and presentation of peptide antigen(GO:0002585) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588) |
| 0.6 | 4.7 | GO:0033299 | secretion of lysosomal enzymes(GO:0033299) |
| 0.6 | 18.1 | GO:0046653 | tetrahydrofolate metabolic process(GO:0046653) |
| 0.6 | 5.2 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.6 | 9.8 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.6 | 10.4 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.6 | 5.6 | GO:0060628 | regulation of ER to Golgi vesicle-mediated transport(GO:0060628) |
| 0.6 | 3.9 | GO:0045007 | depurination(GO:0045007) |
| 0.6 | 11.6 | GO:2000059 | negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059) |
| 0.6 | 8.9 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.5 | 12.5 | GO:0018126 | protein hydroxylation(GO:0018126) |
| 0.5 | 3.1 | GO:0009086 | methionine biosynthetic process(GO:0009086) |
| 0.5 | 1.5 | GO:0071934 | thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934) |
| 0.5 | 21.2 | GO:2000816 | homologous chromosome segregation(GO:0045143) negative regulation of mitotic sister chromatid separation(GO:2000816) |
| 0.5 | 45.5 | GO:0090114 | COPII-coated vesicle budding(GO:0090114) |
| 0.5 | 8.4 | GO:0060965 | negative regulation of gene silencing by miRNA(GO:0060965) |
| 0.5 | 3.7 | GO:0030091 | protein repair(GO:0030091) |
| 0.5 | 6.3 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
| 0.4 | 3.1 | GO:0001302 | replicative cell aging(GO:0001302) |
| 0.4 | 4.0 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.4 | 9.6 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.4 | 3.0 | GO:0046726 | positive regulation by virus of viral protein levels in host cell(GO:0046726) |
| 0.4 | 5.6 | GO:1901223 | negative regulation of NIK/NF-kappaB signaling(GO:1901223) |
| 0.4 | 3.0 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.4 | 43.3 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.4 | 2.1 | GO:0003025 | regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) glossopharyngeal nerve development(GO:0021563) |
| 0.4 | 2.9 | GO:0032808 | lacrimal gland development(GO:0032808) |
| 0.4 | 0.4 | GO:0060648 | mammary gland bud morphogenesis(GO:0060648) |
| 0.4 | 2.0 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.4 | 0.8 | GO:0048200 | COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
| 0.4 | 14.1 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.4 | 2.3 | GO:0045629 | negative regulation of T-helper 2 cell differentiation(GO:0045629) |
| 0.4 | 7.7 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.4 | 5.4 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
| 0.4 | 3.4 | GO:0007023 | post-chaperonin tubulin folding pathway(GO:0007023) |
| 0.4 | 4.1 | GO:1904776 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.4 | 1.8 | GO:0006287 | base-excision repair, gap-filling(GO:0006287) |
| 0.4 | 7.2 | GO:0002230 | positive regulation of defense response to virus by host(GO:0002230) |
| 0.4 | 14.2 | GO:0000281 | mitotic cytokinesis(GO:0000281) |
| 0.4 | 7.1 | GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190) |
| 0.3 | 1.0 | GO:1902774 | late endosome to lysosome transport(GO:1902774) |
| 0.3 | 3.3 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.3 | 6.8 | GO:0010592 | positive regulation of lamellipodium assembly(GO:0010592) |
| 0.3 | 6.0 | GO:0048311 | mitochondrion distribution(GO:0048311) |
| 0.3 | 6.0 | GO:0061014 | positive regulation of mRNA catabolic process(GO:0061014) |
| 0.3 | 11.0 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 0.3 | 3.3 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.3 | 6.6 | GO:0071431 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.3 | 2.2 | GO:0046604 | positive regulation of mitotic centrosome separation(GO:0046604) |
| 0.3 | 19.9 | GO:0006283 | transcription-coupled nucleotide-excision repair(GO:0006283) |
| 0.3 | 4.4 | GO:0006782 | protoporphyrinogen IX biosynthetic process(GO:0006782) |
| 0.3 | 4.4 | GO:0030916 | otic vesicle formation(GO:0030916) |
| 0.3 | 8.4 | GO:0045948 | positive regulation of translational initiation(GO:0045948) |
| 0.3 | 6.2 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.3 | 3.2 | GO:0000492 | box C/D snoRNP assembly(GO:0000492) |
| 0.3 | 1.0 | GO:1903173 | phytol metabolic process(GO:0033306) fatty alcohol metabolic process(GO:1903173) |
| 0.2 | 7.6 | GO:0032008 | positive regulation of TOR signaling(GO:0032008) |
| 0.2 | 27.5 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 0.2 | 6.3 | GO:2000785 | regulation of autophagosome assembly(GO:2000785) |
| 0.2 | 10.6 | GO:0031440 | regulation of mRNA 3'-end processing(GO:0031440) |
| 0.2 | 4.5 | GO:0042226 | interleukin-6 biosynthetic process(GO:0042226) |
| 0.2 | 17.5 | GO:0070126 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 0.2 | 3.0 | GO:0071985 | multivesicular body sorting pathway(GO:0071985) |
| 0.2 | 3.2 | GO:0090136 | epithelial cell-cell adhesion(GO:0090136) |
| 0.2 | 3.4 | GO:0006703 | estrogen biosynthetic process(GO:0006703) |
| 0.2 | 1.1 | GO:0032202 | telomere assembly(GO:0032202) |
| 0.2 | 1.1 | GO:0030242 | pexophagy(GO:0030242) |
| 0.2 | 3.5 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.2 | 1.5 | GO:0070828 | heterochromatin organization(GO:0070828) |
| 0.2 | 3.3 | GO:0010663 | positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666) |
| 0.2 | 2.1 | GO:0031848 | protection from non-homologous end joining at telomere(GO:0031848) |
| 0.2 | 1.4 | GO:1902474 | positive regulation of protein localization to synapse(GO:1902474) |
| 0.2 | 6.5 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.2 | 1.6 | GO:0035721 | intraciliary retrograde transport(GO:0035721) |
| 0.2 | 0.8 | GO:2000393 | negative regulation of lamellipodium morphogenesis(GO:2000393) |
| 0.2 | 3.3 | GO:0086069 | bundle of His cell to Purkinje myocyte communication(GO:0086069) |
| 0.2 | 15.5 | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178) |
| 0.2 | 0.8 | GO:1903936 | cellular response to sodium arsenite(GO:1903936) |
| 0.2 | 7.4 | GO:0035066 | positive regulation of histone acetylation(GO:0035066) |
| 0.2 | 2.3 | GO:0051964 | negative regulation of synapse assembly(GO:0051964) |
| 0.2 | 1.5 | GO:0035865 | cellular response to potassium ion(GO:0035865) |
| 0.2 | 6.4 | GO:0014904 | myotube cell development(GO:0014904) |
| 0.2 | 3.5 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 0.2 | 7.0 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
| 0.2 | 1.4 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.2 | 1.6 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 0.2 | 0.5 | GO:0097272 | ammonia homeostasis(GO:0097272) |
| 0.2 | 4.0 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.2 | 4.3 | GO:0046475 | glycerophospholipid catabolic process(GO:0046475) |
| 0.2 | 5.4 | GO:0006301 | postreplication repair(GO:0006301) |
| 0.1 | 3.1 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 0.1 | 3.6 | GO:0031639 | plasminogen activation(GO:0031639) |
| 0.1 | 9.8 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.1 | 9.4 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.1 | 0.9 | GO:0033210 | leptin-mediated signaling pathway(GO:0033210) |
| 0.1 | 6.2 | GO:0018208 | protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208) |
| 0.1 | 5.9 | GO:0030224 | monocyte differentiation(GO:0030224) |
| 0.1 | 2.4 | GO:0043101 | purine-containing compound salvage(GO:0043101) |
| 0.1 | 1.9 | GO:0031063 | regulation of histone deacetylation(GO:0031063) |
| 0.1 | 0.9 | GO:0033088 | negative regulation of immature T cell proliferation in thymus(GO:0033088) |
| 0.1 | 0.7 | GO:0032070 | regulation of deoxyribonuclease activity(GO:0032070) |
| 0.1 | 2.2 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 0.1 | 3.1 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.1 | 1.7 | GO:0020027 | hemoglobin metabolic process(GO:0020027) |
| 0.1 | 2.9 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 0.4 | GO:0006216 | cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087) |
| 0.1 | 0.7 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.1 | 0.8 | GO:1902715 | positive regulation of interferon-gamma secretion(GO:1902715) |
| 0.1 | 3.9 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 0.1 | 0.9 | GO:0072656 | maintenance of protein location in mitochondrion(GO:0072656) |
| 0.1 | 9.8 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.1 | 0.5 | GO:0046784 | viral mRNA export from host cell nucleus(GO:0046784) |
| 0.1 | 10.2 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 0.1 | 2.6 | GO:0051894 | positive regulation of focal adhesion assembly(GO:0051894) positive regulation of adherens junction organization(GO:1903393) |
| 0.1 | 4.4 | GO:0001836 | release of cytochrome c from mitochondria(GO:0001836) |
| 0.1 | 4.0 | GO:1900034 | regulation of cellular response to heat(GO:1900034) |
| 0.1 | 2.5 | GO:0007176 | regulation of epidermal growth factor-activated receptor activity(GO:0007176) |
| 0.1 | 1.8 | GO:0048935 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.1 | 1.2 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.1 | 1.9 | GO:0032986 | nucleosome disassembly(GO:0006337) protein-DNA complex disassembly(GO:0032986) |
| 0.1 | 0.3 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
| 0.1 | 1.1 | GO:0033561 | regulation of water loss via skin(GO:0033561) establishment of skin barrier(GO:0061436) |
| 0.1 | 0.5 | GO:0097105 | presynaptic membrane assembly(GO:0097105) |
| 0.1 | 0.9 | GO:0036258 | multivesicular body organization(GO:0036257) multivesicular body assembly(GO:0036258) |
| 0.1 | 1.2 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.1 | 11.2 | GO:0007623 | circadian rhythm(GO:0007623) |
| 0.0 | 6.3 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 1.5 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.0 | 1.2 | GO:0035065 | regulation of histone acetylation(GO:0035065) |
| 0.0 | 1.2 | GO:0031572 | G2 DNA damage checkpoint(GO:0031572) |
| 0.0 | 1.6 | GO:0061621 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.0 | 5.3 | GO:0006626 | protein targeting to mitochondrion(GO:0006626) |
| 0.0 | 3.9 | GO:0007224 | smoothened signaling pathway(GO:0007224) |
| 0.0 | 0.1 | GO:1990785 | initiation of primordial ovarian follicle growth(GO:0001544) response to water-immersion restraint stress(GO:1990785) |
| 0.0 | 2.4 | GO:0005977 | glycogen metabolic process(GO:0005977) |
| 0.0 | 16.2 | GO:0043312 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 0.0 | 3.9 | GO:0051017 | actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572) |
| 0.0 | 1.3 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.0 | 0.7 | GO:1903959 | regulation of anion transmembrane transport(GO:1903959) |
| 0.0 | 0.6 | GO:0030838 | positive regulation of actin filament polymerization(GO:0030838) |
| 0.0 | 2.3 | GO:0006260 | DNA replication(GO:0006260) |
| 0.0 | 2.0 | GO:0090305 | nucleic acid phosphodiester bond hydrolysis(GO:0090305) |
| 0.0 | 0.2 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.3 | 27.8 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 5.6 | 50.1 | GO:0036449 | microtubule minus-end(GO:0036449) meiotic spindle(GO:0072687) |
| 5.3 | 16.0 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
| 4.3 | 38.3 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 3.4 | 13.6 | GO:0036502 | Derlin-1-VIMP complex(GO:0036502) |
| 3.1 | 25.0 | GO:0097504 | Gemini of coiled bodies(GO:0097504) |
| 3.0 | 14.9 | GO:0043564 | Ku70:Ku80 complex(GO:0043564) |
| 3.0 | 29.6 | GO:0043203 | axon hillock(GO:0043203) |
| 2.9 | 17.5 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 2.7 | 10.8 | GO:0071986 | Ragulator complex(GO:0071986) |
| 2.6 | 13.2 | GO:0032044 | DSIF complex(GO:0032044) |
| 2.6 | 38.4 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 2.5 | 17.6 | GO:0044354 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 2.5 | 12.3 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 2.5 | 7.4 | GO:0017109 | glutamate-cysteine ligase complex(GO:0017109) |
| 2.3 | 6.8 | GO:0036195 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
| 2.1 | 12.7 | GO:0001940 | male pronucleus(GO:0001940) |
| 2.1 | 6.3 | GO:0034991 | nuclear meiotic cohesin complex(GO:0034991) |
| 2.0 | 14.0 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 1.9 | 9.6 | GO:0045272 | plasma membrane respiratory chain complex I(GO:0045272) |
| 1.9 | 22.9 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 1.7 | 7.0 | GO:0048179 | activin receptor complex(GO:0048179) |
| 1.7 | 18.4 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 1.6 | 47.6 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 1.6 | 20.3 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 1.4 | 26.0 | GO:0000812 | Swr1 complex(GO:0000812) |
| 1.3 | 17.0 | GO:0042555 | MCM complex(GO:0042555) |
| 1.0 | 19.1 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 1.0 | 15.2 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.9 | 27.9 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.9 | 4.4 | GO:0045283 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.9 | 9.6 | GO:0032039 | integrator complex(GO:0032039) |
| 0.9 | 6.0 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.8 | 5.9 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.8 | 2.4 | GO:0072557 | IPAF inflammasome complex(GO:0072557) |
| 0.8 | 17.1 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.8 | 8.7 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.8 | 7.1 | GO:0031298 | replication fork protection complex(GO:0031298) |
| 0.7 | 2.2 | GO:1990723 | cytoplasmic periphery of the nuclear pore complex(GO:1990723) |
| 0.7 | 2.9 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 0.7 | 2.1 | GO:0000799 | nuclear condensin complex(GO:0000799) |
| 0.6 | 3.2 | GO:0001651 | dense fibrillar component(GO:0001651) |
| 0.6 | 1.9 | GO:0071817 | MMXD complex(GO:0071817) |
| 0.6 | 17.5 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.6 | 10.4 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.6 | 1.8 | GO:0033593 | BRCA2-MAGE-D1 complex(GO:0033593) |
| 0.6 | 10.7 | GO:0010369 | chromocenter(GO:0010369) |
| 0.6 | 28.8 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.6 | 3.3 | GO:0005638 | lamin filament(GO:0005638) |
| 0.5 | 4.9 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 0.5 | 14.5 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.5 | 16.8 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.5 | 2.4 | GO:1902560 | GMP reductase complex(GO:1902560) |
| 0.5 | 56.9 | GO:0000784 | nuclear chromosome, telomeric region(GO:0000784) |
| 0.5 | 5.9 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.4 | 1.3 | GO:0005600 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.4 | 3.0 | GO:0031415 | NatA complex(GO:0031415) |
| 0.4 | 4.2 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.4 | 2.9 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.4 | 6.2 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.4 | 12.3 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.4 | 1.1 | GO:0034272 | phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272) |
| 0.4 | 6.6 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.4 | 26.5 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.4 | 27.9 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.3 | 4.2 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.3 | 8.6 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.3 | 1.9 | GO:0070545 | PeBoW complex(GO:0070545) |
| 0.3 | 0.9 | GO:0033565 | ESCRT-0 complex(GO:0033565) |
| 0.3 | 0.6 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.3 | 4.4 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.3 | 16.8 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.3 | 6.9 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.3 | 4.1 | GO:0008091 | spectrin(GO:0008091) |
| 0.3 | 5.5 | GO:0044232 | organelle membrane contact site(GO:0044232) |
| 0.3 | 2.2 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.3 | 1.0 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.3 | 14.9 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.3 | 12.1 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.3 | 10.1 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.2 | 4.4 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.2 | 1.9 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.2 | 7.0 | GO:0000421 | pre-autophagosomal structure(GO:0000407) autophagosome membrane(GO:0000421) |
| 0.2 | 3.3 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.2 | 4.1 | GO:0030904 | retromer complex(GO:0030904) |
| 0.2 | 3.9 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.2 | 2.8 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.2 | 8.2 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.2 | 2.1 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.2 | 18.7 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.2 | 1.1 | GO:0032311 | angiogenin-PRI complex(GO:0032311) |
| 0.2 | 4.1 | GO:0046930 | pore complex(GO:0046930) |
| 0.2 | 7.6 | GO:0090544 | BAF-type complex(GO:0090544) |
| 0.2 | 16.5 | GO:0016459 | myosin complex(GO:0016459) |
| 0.2 | 10.7 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 4.6 | GO:0000781 | chromosome, telomeric region(GO:0000781) |
| 0.1 | 2.8 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 0.1 | 1.2 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.1 | 3.5 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.1 | 1.7 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.1 | 0.4 | GO:0000178 | exosome (RNase complex)(GO:0000178) |
| 0.1 | 2.4 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.1 | 1.1 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.1 | 15.7 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.1 | 1.1 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.1 | 20.7 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 1.5 | GO:0000786 | nucleosome(GO:0000786) |
| 0.1 | 2.2 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.1 | 79.1 | GO:0005730 | nucleolus(GO:0005730) |
| 0.1 | 3.5 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 7.1 | GO:0034399 | nuclear periphery(GO:0034399) |
| 0.1 | 1.4 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 5.4 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.1 | 40.2 | GO:1990904 | ribonucleoprotein complex(GO:1990904) |
| 0.1 | 1.6 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.1 | 25.9 | GO:0000785 | chromatin(GO:0000785) |
| 0.1 | 8.1 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.1 | 1.5 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.1 | 1.3 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.1 | 6.3 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 2.1 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 2.9 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.3 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.0 | 11.4 | GO:0005635 | nuclear envelope(GO:0005635) |
| 0.0 | 1.9 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 8.2 | GO:0005874 | microtubule(GO:0005874) |
| 0.0 | 2.3 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 1.0 | GO:0031903 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.4 | 49.5 | GO:0008311 | double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311) |
| 8.7 | 26.2 | GO:0047315 | kynurenine-glyoxylate transaminase activity(GO:0047315) |
| 7.4 | 22.1 | GO:0004418 | hydroxymethylbilane synthase activity(GO:0004418) |
| 6.9 | 27.5 | GO:0004802 | transketolase activity(GO:0004802) |
| 6.0 | 29.8 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 5.1 | 20.3 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 4.6 | 18.4 | GO:0043515 | kinetochore binding(GO:0043515) |
| 4.5 | 18.1 | GO:0004487 | methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488) |
| 3.7 | 11.0 | GO:0004170 | dUTP diphosphatase activity(GO:0004170) |
| 3.5 | 17.6 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 3.5 | 10.4 | GO:0043035 | chromatin insulator sequence binding(GO:0043035) |
| 3.2 | 28.9 | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity(GO:0051575) |
| 2.8 | 11.0 | GO:0004505 | phenylalanine 4-monooxygenase activity(GO:0004505) |
| 2.7 | 13.3 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 2.6 | 7.7 | GO:0000033 | alpha-1,3-mannosyltransferase activity(GO:0000033) |
| 2.5 | 7.4 | GO:0004357 | glutamate-cysteine ligase activity(GO:0004357) |
| 2.2 | 35.1 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 2.2 | 17.5 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
| 2.0 | 28.2 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 1.9 | 38.4 | GO:0015037 | peptide disulfide oxidoreductase activity(GO:0015037) |
| 1.9 | 5.7 | GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) |
| 1.8 | 14.5 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 1.7 | 11.9 | GO:0035368 | selenocysteine insertion sequence binding(GO:0035368) |
| 1.6 | 9.8 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 1.6 | 14.0 | GO:0036042 | long-chain fatty acyl-CoA binding(GO:0036042) |
| 1.5 | 10.6 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 1.5 | 4.4 | GO:0033265 | choline binding(GO:0033265) |
| 1.4 | 12.7 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 1.4 | 63.7 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 1.3 | 5.2 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 1.2 | 7.2 | GO:0015057 | thrombin receptor activity(GO:0015057) |
| 1.2 | 7.0 | GO:0016361 | activin receptor activity, type I(GO:0016361) |
| 1.1 | 4.4 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) |
| 1.1 | 3.2 | GO:0034512 | box C/D snoRNA binding(GO:0034512) |
| 1.0 | 6.3 | GO:0000285 | 1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285) |
| 1.0 | 6.3 | GO:0036033 | mediator complex binding(GO:0036033) |
| 1.0 | 28.8 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.9 | 8.2 | GO:0000990 | transcription factor activity, core RNA polymerase binding(GO:0000990) |
| 0.9 | 4.4 | GO:0016749 | 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749) |
| 0.9 | 4.3 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.9 | 3.4 | GO:0016509 | long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509) |
| 0.8 | 2.5 | GO:0000252 | C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity(GO:0047012) |
| 0.8 | 4.0 | GO:0016427 | tRNA (cytosine) methyltransferase activity(GO:0016427) |
| 0.8 | 33.6 | GO:0019956 | chemokine binding(GO:0019956) |
| 0.8 | 5.3 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 0.8 | 13.6 | GO:1990381 | ubiquitin-specific protease binding(GO:1990381) |
| 0.8 | 6.0 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
| 0.7 | 3.7 | GO:0010340 | carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998) |
| 0.7 | 5.4 | GO:1990829 | C-rich single-stranded DNA binding(GO:1990829) |
| 0.6 | 32.4 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.6 | 3.1 | GO:0005152 | interleukin-1 receptor antagonist activity(GO:0005152) |
| 0.6 | 4.9 | GO:0015288 | porin activity(GO:0015288) |
| 0.6 | 19.9 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.6 | 8.2 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.6 | 9.0 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.6 | 16.4 | GO:0070034 | telomerase RNA binding(GO:0070034) |
| 0.5 | 30.4 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 0.5 | 1.5 | GO:0015234 | thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403) |
| 0.5 | 1.5 | GO:0004507 | steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783) |
| 0.5 | 22.9 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.5 | 11.9 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.5 | 2.4 | GO:0016657 | GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657) |
| 0.5 | 2.4 | GO:0047115 | phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115) |
| 0.5 | 3.3 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.5 | 8.4 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.5 | 4.2 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.4 | 3.1 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
| 0.4 | 15.5 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.4 | 7.1 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.4 | 4.1 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.4 | 2.9 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 0.4 | 14.2 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.4 | 6.8 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.4 | 9.6 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.4 | 6.2 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.4 | 6.1 | GO:0004551 | nucleotide diphosphatase activity(GO:0004551) |
| 0.4 | 6.6 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.4 | 6.0 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.3 | 1.0 | GO:0008670 | 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670) trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166) |
| 0.3 | 3.4 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.3 | 7.0 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.3 | 18.7 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.3 | 0.3 | GO:0016211 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.3 | 9.9 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.3 | 2.8 | GO:0008312 | 7S RNA binding(GO:0008312) |
| 0.3 | 8.5 | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.3 | 10.8 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.3 | 5.9 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.3 | 8.7 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.3 | 4.5 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.3 | 5.8 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.2 | 7.4 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.2 | 2.2 | GO:0089720 | caspase binding(GO:0089720) |
| 0.2 | 1.7 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.2 | 4.4 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.2 | 0.7 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.2 | 2.1 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.2 | 6.2 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.2 | 9.1 | GO:0004386 | helicase activity(GO:0004386) |
| 0.2 | 2.4 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.2 | 3.0 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.2 | 0.6 | GO:0032090 | Pyrin domain binding(GO:0032090) |
| 0.2 | 5.6 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.2 | 4.0 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.2 | 3.9 | GO:0019104 | DNA N-glycosylase activity(GO:0019104) |
| 0.2 | 10.0 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.2 | 2.3 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.2 | 8.8 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.2 | 3.0 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.2 | 1.8 | GO:0008296 | 3'-5'-exodeoxyribonuclease activity(GO:0008296) |
| 0.2 | 33.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 5.0 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.2 | 3.3 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.2 | 41.9 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.2 | 1.2 | GO:0000268 | peroxisome targeting sequence binding(GO:0000268) |
| 0.1 | 23.9 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.1 | 17.1 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.1 | 3.5 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.1 | 5.7 | GO:0004527 | exonuclease activity(GO:0004527) |
| 0.1 | 15.8 | GO:0020037 | heme binding(GO:0020037) |
| 0.1 | 2.8 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.1 | 1.1 | GO:0008428 | ribonuclease inhibitor activity(GO:0008428) |
| 0.1 | 3.3 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 10.5 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.1 | 0.9 | GO:0019158 | glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 0.1 | 1.1 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.1 | 1.6 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) dynein light chain binding(GO:0045503) |
| 0.1 | 1.5 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.1 | 2.4 | GO:0015149 | hexose transmembrane transporter activity(GO:0015149) |
| 0.1 | 5.5 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.1 | 1.5 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.1 | 0.2 | GO:0008511 | sodium:potassium:chloride symporter activity(GO:0008511) |
| 0.1 | 6.3 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.1 | 5.8 | GO:0005525 | GTP binding(GO:0005525) |
| 0.1 | 11.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 0.4 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.1 | 0.4 | GO:0034056 | estrogen response element binding(GO:0034056) |
| 0.1 | 19.0 | GO:0008236 | serine-type peptidase activity(GO:0008236) |
| 0.1 | 3.4 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.1 | 0.5 | GO:0042301 | phosphate ion binding(GO:0042301) |
| 0.1 | 1.2 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.1 | 1.3 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.1 | 2.2 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.1 | 15.3 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.1 | 0.4 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.0 | 11.4 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 2.9 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.0 | 0.5 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 0.8 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 1.9 | GO:0043021 | ribonucleoprotein complex binding(GO:0043021) |
| 0.0 | 1.2 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 4.2 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.0 | 0.7 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 1.8 | GO:0016836 | hydro-lyase activity(GO:0016836) |
| 0.0 | 0.3 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
| 0.0 | 1.1 | GO:0016303 | 1-phosphatidylinositol-3-kinase activity(GO:0016303) |
| 0.0 | 27.6 | GO:0003723 | RNA binding(GO:0003723) |
| 0.0 | 0.4 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 0.9 | GO:0016279 | lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 43.7 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 1.0 | 25.8 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.6 | 5.2 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.6 | 45.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.6 | 27.2 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.6 | 14.9 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.6 | 30.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.4 | 12.3 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.3 | 13.5 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.3 | 13.6 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.3 | 3.3 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.3 | 7.2 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.2 | 16.0 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.2 | 17.4 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.2 | 8.7 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 5.4 | PID ATM PATHWAY | ATM pathway |
| 0.2 | 10.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 2.9 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 2.4 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 4.5 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.1 | 10.7 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 9.2 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 3.3 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 7.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 1.4 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.1 | 2.2 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 4.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 6.1 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.1 | 7.5 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 5.9 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 5.5 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 7.0 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 4.3 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 4.0 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 3.1 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.1 | 2.7 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 0.9 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.0 | 0.8 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 1.8 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 1.1 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 1.3 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 2.1 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.1 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 0.8 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 2.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.1 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 53.4 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 2.2 | 42.7 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 1.9 | 17.5 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 1.2 | 17.3 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 1.0 | 28.5 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.9 | 14.4 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.9 | 33.1 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.9 | 26.5 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.9 | 24.4 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.8 | 18.3 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.8 | 14.9 | REACTOME INTEGRATION OF PROVIRUS | Genes involved in Integration of provirus |
| 0.8 | 20.0 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.7 | 13.2 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.6 | 24.5 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.6 | 9.8 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.6 | 20.3 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 0.6 | 25.4 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.6 | 44.0 | REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT | Genes involved in p53-Independent G1/S DNA damage checkpoint |
| 0.6 | 44.5 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.6 | 17.6 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.6 | 26.3 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.5 | 4.9 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.5 | 13.4 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.5 | 10.6 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.5 | 7.0 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.5 | 15.1 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.4 | 10.5 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.4 | 9.3 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.4 | 31.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.3 | 11.4 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.3 | 7.3 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.3 | 7.7 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.3 | 24.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.3 | 8.4 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.2 | 10.6 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.2 | 5.2 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.2 | 11.2 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 0.2 | 33.6 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.2 | 4.0 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.2 | 3.9 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.2 | 1.8 | REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY | Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| 0.2 | 4.7 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.2 | 3.0 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.2 | 14.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 6.8 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 3.4 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 4.5 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 3.0 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.1 | 11.4 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 2.4 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.1 | 3.3 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 5.5 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 1.8 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 8.1 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 0.8 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.1 | 2.3 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.1 | 0.2 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.1 | 2.1 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 17.5 | REACTOME INTEGRATION OF ENERGY METABOLISM | Genes involved in Integration of energy metabolism |
| 0.1 | 1.3 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.1 | 3.9 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 1.1 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.1 | 1.5 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.1 | 14.5 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 9.1 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 2.5 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 5.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 0.8 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 0.7 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.9 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 6.4 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 0.7 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 0.7 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 0.9 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 1.3 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |