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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for INSM1
Z-value: 0.68
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Transcription factors associated with INSM1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| INSM1 | hg38_v1_chr20_+_20368096_20368113 | 0.24 | 4.3e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of INSM1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 16.4 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 1.4 | 12.2 | GO:0003190 | atrioventricular valve formation(GO:0003190) |
| 0.6 | 11.7 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 0.2 | 9.6 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
| 0.0 | 9.4 | GO:0007605 | sensory perception of sound(GO:0007605) |
| 1.6 | 7.8 | GO:1901091 | regulation of protein tetramerization(GO:1901090) negative regulation of protein tetramerization(GO:1901091) regulation of protein homotetramerization(GO:1901093) negative regulation of protein homotetramerization(GO:1901094) |
| 0.1 | 7.6 | GO:0060997 | dendritic spine morphogenesis(GO:0060997) |
| 0.1 | 7.5 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 2.3 | 7.0 | GO:1904933 | regulation of cell proliferation in midbrain(GO:1904933) |
| 1.0 | 6.7 | GO:0070127 | tRNA aminoacylation for mitochondrial protein translation(GO:0070127) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.6 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.6 | 15.3 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 15.1 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 13.1 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.1 | 12.9 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 12.9 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.1 | 7.8 | GO:0031903 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.1 | 7.6 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 6.5 | GO:0005875 | microtubule associated complex(GO:0005875) |
| 0.4 | 5.8 | GO:0001741 | XY body(GO:0001741) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 16.4 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.1 | 10.3 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 9.0 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 1.6 | 7.8 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.5 | 7.5 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 7.5 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.3 | 6.7 | GO:0004812 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 0.1 | 6.7 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 2.1 | 6.2 | GO:0001641 | group II metabotropic glutamate receptor activity(GO:0001641) |
| 1.0 | 5.9 | GO:0005219 | ryanodine-sensitive calcium-release channel activity(GO:0005219) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 8.6 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 3.8 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 3.6 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 3.0 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 2.9 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 2.6 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 2.6 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.1 | 2.2 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 2.2 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.4 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 11.6 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.3 | 6.2 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.4 | 6.0 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.1 | 5.7 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.1 | 5.7 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.3 | 5.4 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.1 | 4.8 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 4.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 3.9 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |