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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for IRF2_STAT2_IRF8_IRF1
Z-value: 3.49
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Transcription factors associated with IRF2_STAT2_IRF8_IRF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF1 | hg38_v1_chr5_-_132490750_132490840 | 0.80 | 9.7e-50 | Click! |
| IRF2 | hg38_v1_chr4_-_184474518_184474556 | 0.71 | 1.9e-34 | Click! |
| IRF8 | hg38_v1_chr16_+_85908988_85909033 | 0.61 | 1.7e-23 | Click! |
| STAT2 | hg38_v1_chr12_-_56360084_56360146 | 0.13 | 6.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF2_STAT2_IRF8_IRF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.7 | 886.1 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 21.8 | 436.4 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 33.4 | 267.3 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 8.2 | 228.3 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 45.1 | 225.5 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 4.2 | 199.2 | GO:0032731 | positive regulation of interleukin-1 beta production(GO:0032731) |
| 18.1 | 180.5 | GO:0018377 | protein myristoylation(GO:0018377) |
| 16.4 | 180.1 | GO:1903943 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 1.4 | 170.7 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
| 7.8 | 163.9 | GO:0035455 | response to interferon-alpha(GO:0035455) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 669.5 | GO:0005654 | nucleoplasm(GO:0005654) |
| 75.9 | 531.3 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 1.2 | 458.9 | GO:0031965 | nuclear membrane(GO:0031965) |
| 2.0 | 264.5 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 49.6 | 248.2 | GO:0042825 | TAP complex(GO:0042825) |
| 0.5 | 229.8 | GO:0016607 | nuclear speck(GO:0016607) |
| 2.9 | 202.5 | GO:0015030 | Cajal body(GO:0015030) |
| 9.2 | 202.2 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.1 | 180.6 | GO:0005739 | mitochondrion(GO:0005739) |
| 1.5 | 180.3 | GO:0005643 | nuclear pore(GO:0005643) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 22.3 | 623.8 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 1.2 | 438.0 | GO:0003924 | GTPase activity(GO:0003924) |
| 9.2 | 275.8 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 42.1 | 252.5 | GO:0046979 | TAP2 binding(GO:0046979) |
| 1.3 | 232.8 | GO:0001047 | core promoter binding(GO:0001047) |
| 16.4 | 213.5 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 1.7 | 205.0 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.3 | 197.6 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 25.5 | 152.8 | GO:0015333 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) |
| 10.9 | 151.9 | GO:0031386 | protein tag(GO:0031386) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 280.6 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 2.4 | 213.9 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 6.6 | 209.7 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 1.1 | 205.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.9 | 155.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 2.1 | 141.4 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 2.7 | 139.6 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 1.0 | 70.7 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 2.7 | 67.5 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 2.4 | 66.1 | PID TRAIL PATHWAY | TRAIL signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.2 | 1422.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 10.2 | 757.0 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 8.3 | 266.4 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 5.4 | 260.4 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 22.6 | 225.5 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 1.6 | 129.8 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 5.6 | 101.5 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 19.0 | 95.2 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 6.8 | 67.9 | REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| 2.0 | 62.7 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |