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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for IRF3
Z-value: 0.91
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Transcription factors associated with IRF3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF3 | hg38_v1_chr19_-_49665603_49665617 | 0.47 | 1.7e-13 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_32854179 Show fit | 20.46 |
ENST00000374859.3
|
proteasome 20S subunit beta 9 |
|
| chr1_+_1013485 Show fit | 19.00 |
ENST00000649529.1
|
ISG15 ubiquitin like modifier |
|
| chr14_+_24136152 Show fit | 14.42 |
ENST00000559123.5
ENST00000206451.11 ENST00000382708.7 ENST00000561435.5 |
proteasome activator subunit 1 |
|
| chr15_+_88639009 Show fit | 14.40 |
ENST00000306072.10
|
interferon stimulated exonuclease gene 20 |
|
| chr12_+_112978386 Show fit | 13.69 |
ENST00000342315.8
|
2'-5'-oligoadenylate synthetase 2 |
|
| chr19_-_17405554 Show fit | 13.19 |
ENST00000252593.7
|
bone marrow stromal cell antigen 2 |
|
| chr8_-_66613208 Show fit | 12.63 |
ENST00000522677.8
|
MYB proto-oncogene like 1 |
|
| chr1_+_78649818 Show fit | 11.80 |
ENST00000370747.9
ENST00000438486.1 |
interferon induced protein 44 |
|
| chr21_+_41420515 Show fit | 11.74 |
ENST00000398600.6
ENST00000679626.1 |
MX dynamin like GTPase 1 |
|
| chr19_+_18173804 Show fit | 10.63 |
ENST00000407280.4
|
IFI30 lysosomal thiol reductase |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 53.5 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 4.7 | 28.5 | GO:2000110 | negative regulation of macrophage apoptotic process(GO:2000110) |
| 5.7 | 28.4 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 3.4 | 27.5 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 2.7 | 27.3 | GO:0018377 | protein myristoylation(GO:0018377) |
| 1.0 | 27.3 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 1.6 | 22.5 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 6.6 | 19.7 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 1.7 | 15.3 | GO:1902570 | protein localization to nucleolus(GO:1902570) |
| 4.8 | 14.4 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 62.5 | GO:0005829 | cytosol(GO:0005829) |
| 5.6 | 22.4 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 2.9 | 20.5 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 3.9 | 19.7 | GO:0042825 | TAP complex(GO:0042825) |
| 0.0 | 18.4 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.2 | 16.4 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 14.0 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 13.9 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.6 | 13.7 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.2 | 13.2 | GO:0005771 | multivesicular body(GO:0005771) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 24.9 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 1.9 | 24.3 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 3.2 | 22.4 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 3.4 | 20.6 | GO:0046979 | TAP2 binding(GO:0046979) |
| 0.7 | 20.5 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 20.1 | GO:0042802 | identical protein binding(GO:0042802) |
| 1.4 | 19.0 | GO:0031386 | protein tag(GO:0031386) |
| 0.1 | 17.4 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.4 | 15.8 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 4.8 | 14.4 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.2 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.2 | 15.5 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 15.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.4 | 13.7 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.2 | 10.3 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 6.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 5.5 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.2 | 5.4 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.1 | 5.4 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 4.0 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 89.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.7 | 46.9 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 2.1 | 46.6 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 1.1 | 24.3 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.4 | 12.7 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.2 | 10.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 8.5 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.4 | 6.7 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.1 | 5.5 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.3 | 5.4 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |