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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for IRF6_IRF4_IRF5
Z-value: 1.18
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Transcription factors associated with IRF6_IRF4_IRF5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF6 | hg38_v1_chr1_-_209806124_209806175 | 0.16 | 1.5e-02 | Click! |
| IRF5 | hg38_v1_chr7_+_128937917_128937994 | 0.06 | 4.2e-01 | Click! |
| IRF4 | hg38_v1_chr6_+_391743_391759 | 0.03 | 6.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF6_IRF4_IRF5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 18.4 | 147.0 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 6.1 | 121.4 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 9.4 | 46.9 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 0.3 | 21.2 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 6.8 | 20.3 | GO:0006679 | glucosylceramide biosynthetic process(GO:0006679) |
| 0.4 | 19.2 | GO:0033198 | response to ATP(GO:0033198) |
| 2.7 | 19.1 | GO:0090191 | negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191) |
| 0.5 | 17.0 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 2.3 | 16.0 | GO:0052564 | response to immune response of other organism involved in symbiotic interaction(GO:0052564) response to host immune response(GO:0052572) |
| 3.2 | 15.9 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 145.5 | GO:0045121 | membrane raft(GO:0045121) |
| 0.3 | 112.4 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.3 | 36.8 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.3 | 36.3 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 29.7 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 22.6 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.3 | 22.1 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.4 | 18.4 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 14.7 | GO:0005840 | ribosome(GO:0005840) |
| 0.5 | 12.6 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.2 | 147.0 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.3 | 118.7 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.4 | 52.9 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.1 | 43.2 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 0.8 | 31.5 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 28.0 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 2.0 | 20.3 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 3.8 | 19.2 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 3.2 | 16.0 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.2 | 14.3 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 46.6 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.2 | 32.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.5 | 19.2 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 14.3 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.3 | 13.8 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.2 | 11.0 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.5 | 7.2 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.2 | 7.1 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.2 | 7.1 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.2 | 6.9 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 157.6 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 4.7 | 46.9 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.3 | 24.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.4 | 20.3 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.2 | 18.1 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 14.7 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.4 | 13.9 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.1 | 12.8 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.3 | 9.0 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.2 | 7.4 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |