ISMARA results: IRF7

Project

GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation

Downloads

Results for IRF7

Z-value: 1.29

Motif logo

Transcription factors associated with IRF7

Gene Symbol	Gene ID	Gene Info
IRF7 Ensembl NCBI GeneCards UniProt	ENSG00000185507.21	IRF7

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
IRF7	hg38_v1_chr11_-_615570_615728	-0.23	7.8e-04	Click!

Activity profile of IRF7 motif

Sorted Z-values of IRF7 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF7

View svg image
View png image

Top targets:

Search:

Show entries

Promoter	Score	Transcript	Gene	Gene Info
chr2_-_150487658 Show fit	42.91	ENST00000375734.6 ENST00000263895.9 ENST00000454202.5	RND3 Ensembl NCBI GeneCards UniProt Show fit	Rho family GTPase 3
chr2_-_55010348 Show fit	28.61	ENST00000394609.6	RTN4 Ensembl NCBI GeneCards UniProt Show fit	reticulon 4
chr1_+_1013485 Show fit	24.43	ENST00000649529.1	ISG15 Ensembl NCBI GeneCards UniProt Show fit	ISG15 ubiquitin like modifier
chrX_-_20218941 Show fit	24.40	ENST00000457145.6	RPS6KA3 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein S6 kinase A3
chr12_-_50222694 Show fit	23.69	ENST00000552783.5	LIMA1 Ensembl NCBI GeneCards UniProt Show fit	LIM domain and actin binding 1
chr12_+_19205294 Show fit	23.02	ENST00000424268.5	PLEKHA5 Ensembl NCBI GeneCards UniProt Show fit	pleckstrin homology domain containing A5
chrX_+_103628692 Show fit	21.52	ENST00000372626.7	TCEAL1 Ensembl NCBI GeneCards UniProt Show fit	transcription elongation factor A like 1
chr2_-_37672448 Show fit	19.15	ENST00000611976.1	CDC42EP3 Ensembl NCBI GeneCards UniProt Show fit	CDC42 effector protein 3
chr12_-_50222348 Show fit	17.75	ENST00000552823.5 ENST00000552909.5	LIMA1 Ensembl NCBI GeneCards UniProt Show fit	LIM domain and actin binding 1
chr1_-_149927756 Show fit	17.69	ENST00000271628.9	SF3B4 Ensembl NCBI GeneCards UniProt Show fit	splicing factor 3b subunit 4

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	83.7	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
5.8	58.2	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.1	43.9	GO:0030036	actin cytoskeleton organization(GO:0030036)
0.7	41.4	GO:0031529	ruffle organization(GO:0031529)
3.7	41.1	GO:2000645	negative regulation of receptor catabolic process(GO:2000645)
1.7	37.6	GO:0051639	actin filament network formation(GO:0051639)
2.1	30.1	GO:0001778	plasma membrane repair(GO:0001778)
1.2	29.5	GO:0070262	peptidyl-serine dephosphorylation(GO:0070262)
1.0	26.6	GO:0032291	central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
8.5	25.6	GO:1901254	modulation by host of viral RNA genome replication(GO:0044830) positive regulation of intracellular transport of viral material(GO:1901254)

Showing 1 to 10 of 256 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.9	49.2	GO:0005916	fascia adherens(GO:0005916)
0.3	48.4	GO:0008021	synaptic vesicle(GO:0008021)
1.8	45.6	GO:0071782	endoplasmic reticulum tubular network(GO:0071782)
3.7	44.1	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.1	42.9	GO:0000139	Golgi membrane(GO:0000139)
0.6	41.4	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.7	29.5	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.1	26.0	GO:0005681	spliceosomal complex(GO:0005681)
8.5	25.6	GO:1902737	dendritic filopodium(GO:1902737)
0.2	25.3	GO:0005901	caveola(GO:0005901)

Showing 1 to 10 of 139 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	87.1	GO:0045296	cadherin binding(GO:0045296)
2.2	61.3	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
1.7	46.4	GO:0017166	vinculin binding(GO:0017166)
1.9	42.4	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.9	39.6	GO:0003785	actin monomer binding(GO:0003785)
0.8	38.4	GO:0050699	WW domain binding(GO:0050699)
4.3	25.6	GO:0034046	poly(G) binding(GO:0034046)
0.9	25.6	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1	25.4	GO:0003924	GTPase activity(GO:0003924)
0.7	25.2	GO:0001972	retinoic acid binding(GO:0001972)

Showing 1 to 10 of 191 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.1	87.0	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.6	68.2	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.6	34.2	PID AURORA B PATHWAY	Aurora B signaling
0.3	27.5	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.3	26.6	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.6	24.4	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.4	22.7	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.3	21.3	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.3	18.0	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.3	16.9	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction

Showing 1 to 10 of 54 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.2	83.7	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.7	67.8	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
1.5	50.8	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
2.6	41.1	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.4	41.0	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.4	34.1	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.5	33.8	REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS	Genes involved in Post NMDA receptor activation events
0.5	32.0	REACTOME G1 PHASE	Genes involved in G1 Phase
0.5	25.6	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.5	21.5	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis

Showing 1 to 10 of 86 entries

Results for IRF7

Z-value: 1.29

Motif logo

Transcription factors associated with IRF7

Activity-expression correlation:

Activity profile of IRF7 motif

Sorted Z-values of IRF7 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF7

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: