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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for IRF9

Z-value: 0.91

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Transcription factors associated with IRF9

Gene Symbol Gene ID Gene Info
IRF9
ENSG00000213928.9 IRF9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF9hg38_v1_chr14_+_24161257_241613220.511.6e-15Click!

Activity profile of IRF9 motif

Sorted Z-values of IRF9 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF9

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr21_+_41426590 33.50 ENST00000679543.1
ENST00000680364.1
MX1
MX dynamin like GTPase 1
chr21_+_41361999 21.47 ENST00000436410.5
ENST00000435611.6
ENST00000330714.8
MX2
MX dynamin like GTPase 2
chr21_+_41426197 19.88 ENST00000680942.1
ENST00000288383.11
ENST00000679386.1
MX1
MX dynamin like GTPase 1
chr21_+_41426031 19.42 ENST00000455164.6
ENST00000681849.1
ENST00000679705.1
ENST00000424365.6
MX1
MX dynamin like GTPase 1
chr21_+_41426168 17.69 ENST00000681266.1
ENST00000417963.6
MX1
MX dynamin like GTPase 1
chr21_+_41426289 16.34 ENST00000679408.1
ENST00000681039.1
ENST00000681671.1
MX1
MX dynamin like GTPase 1
chr21_+_41426232 16.25 ENST00000398598.8
ENST00000681896.1
ENST00000680629.1
ENST00000680760.1
ENST00000680176.1
ENST00000680776.1
ENST00000681607.1
ENST00000680536.1
MX1
MX dynamin like GTPase 1
chr2_-_55693817 10.37 ENST00000625249.1
ENST00000447944.7
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr8_-_28083920 10.11 ENST00000413272.7
NUGGC
nuclear GTPase, germinal center associated
chr15_+_91100194 10.10 ENST00000394232.6
SV2B
synaptic vesicle glycoprotein 2B
chr14_+_24161257 9.77 ENST00000396864.8
ENST00000557894.5
ENST00000559284.5
ENST00000560275.5
IRF9
interferon regulatory factor 9
chr12_+_112907006 9.34 ENST00000680455.1
ENST00000551241.6
ENST00000550689.2
ENST00000679841.1
ENST00000679494.1
ENST00000553185.2
OAS1
2'-5'-oligoadenylate synthetase 1
chr17_+_6755834 9.34 ENST00000346752.8
XAF1
XIAP associated factor 1
chr3_-_122564253 9.19 ENST00000492382.5
ENST00000682323.1
ENST00000462315.5
PARP9
poly(ADP-ribose) polymerase family member 9
chr12_+_112906777 9.13 ENST00000452357.7
ENST00000445409.7
OAS1
2'-5'-oligoadenylate synthetase 1
chr12_+_112906949 9.10 ENST00000679971.1
ENST00000675868.2
ENST00000550883.2
ENST00000553152.2
ENST00000202917.10
ENST00000679467.1
ENST00000680659.1
ENST00000540589.3
ENST00000552526.2
ENST00000681228.1
ENST00000680934.1
ENST00000681700.1
ENST00000679987.1
OAS1
2'-5'-oligoadenylate synthetase 1
chr11_-_615570 9.08 ENST00000649187.1
ENST00000647801.1
ENST00000397566.5
ENST00000397570.5
IRF7
interferon regulatory factor 7
chr11_-_615921 7.88 ENST00000348655.11
ENST00000525445.6
ENST00000330243.9
IRF7
interferon regulatory factor 7
chr4_-_76023489 7.60 ENST00000306602.3
CXCL10
C-X-C motif chemokine ligand 10
chr1_-_150765785 7.54 ENST00000680311.1
ENST00000681728.1
ENST00000680288.1
CTSS
cathepsin S
chr3_-_121660892 7.28 ENST00000428394.6
ENST00000314583.8
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr1_-_150765735 7.18 ENST00000679898.1
ENST00000448301.7
ENST00000680664.1
ENST00000679512.1
ENST00000368985.8
ENST00000679582.1
CTSS
cathepsin S
chr17_+_6756035 7.08 ENST00000361842.8
ENST00000574907.5
XAF1
XIAP associated factor 1
chr4_-_168318770 6.92 ENST00000680771.1
ENST00000514995.2
DDX60
DExD/H-box helicase 60
chr11_+_114060204 6.84 ENST00000683318.1
ZBTB16
zinc finger and BTB domain containing 16
chr12_-_121039204 6.66 ENST00000620239.5
OASL
2'-5'-oligoadenylate synthetase like
chr1_+_78649818 6.42 ENST00000370747.9
ENST00000438486.1
IFI44
interferon induced protein 44
chr6_+_6588708 6.38 ENST00000230568.5
LY86
lymphocyte antigen 86
chr12_-_121039236 6.31 ENST00000257570.9
OASL
2'-5'-oligoadenylate synthetase like
chr13_+_49495941 5.78 ENST00000378319.8
ENST00000496623.5
ENST00000426879.5
PHF11
PHD finger protein 11
chr13_+_49496355 5.70 ENST00000496612.5
ENST00000357596.7
ENST00000485919.5
ENST00000442195.5
PHF11
PHD finger protein 11
chr9_-_32526185 5.38 ENST00000379883.3
ENST00000379868.6
ENST00000679859.1
DDX58
DExD/H-box helicase 58
chr12_-_121039156 5.34 ENST00000339275.10
OASL
2'-5'-oligoadenylate synthetase like
chr19_-_17405554 5.30 ENST00000252593.7
BST2
bone marrow stromal cell antigen 2
chr4_-_168318743 5.14 ENST00000393743.8
DDX60
DExD/H-box helicase 60
chr10_+_89332484 4.66 ENST00000371811.4
ENST00000680037.1
ENST00000679583.1
ENST00000679897.1
IFIT3
interferon induced protein with tetratricopeptide repeats 3
chr20_-_49278416 4.62 ENST00000371754.8
ZNFX1
zinc finger NFX1-type containing 1
chr6_-_24935942 4.35 ENST00000645100.1
ENST00000643898.2
ENST00000613507.4
RIPOR2
RHO family interacting cell polarization regulator 2
chr17_-_42112674 4.34 ENST00000251642.8
ENST00000591220.5
DHX58
DExH-box helicase 58
chr11_-_60952134 4.29 ENST00000679573.1
ENST00000681882.1
ENST00000681951.1
ENST00000227880.8
SLC15A3
solute carrier family 15 member 3
chr12_+_112938422 4.17 ENST00000680044.1
ENST00000680966.1
ENST00000548514.2
ENST00000681497.1
ENST00000551007.1
ENST00000228928.12
ENST00000680438.1
ENST00000681147.1
ENST00000679354.1
ENST00000681085.1
ENST00000680161.1
OAS3
2'-5'-oligoadenylate synthetase 3
chr3_-_179451387 4.14 ENST00000675901.1
ENST00000232564.8
ENST00000674862.1
ENST00000497513.1
GNB4
G protein subunit beta 4
chr11_-_60952067 4.13 ENST00000681275.1
SLC15A3
solute carrier family 15 member 3
chr1_+_159010002 4.12 ENST00000359709.7
IFI16
interferon gamma inducible protein 16
chr11_-_60952559 3.99 ENST00000538739.2
SLC15A3
solute carrier family 15 member 3
chr1_+_92168915 3.77 ENST00000637221.2
BTBD8
BTB domain containing 8
chr5_-_95961830 3.73 ENST00000513343.1
ENST00000237853.9
ELL2
elongation factor for RNA polymerase II 2
chr12_+_112938523 3.72 ENST00000679483.1
ENST00000679493.1
OAS3
2'-5'-oligoadenylate synthetase 3
chr12_+_112938284 3.70 ENST00000681346.1
OAS3
2'-5'-oligoadenylate synthetase 3
chr19_+_17405734 3.68 ENST00000635572.1
ENST00000634675.1
ENST00000634813.1
ENST00000647283.1
ENST00000635435.2
ENST00000634731.2
ENST00000635339.1
ENST00000528604.5
BISPR
MVB12A
BST2 interferon stimulated positive regulator
multivesicular body subunit 12A
chr11_-_57567617 3.66 ENST00000287156.9
UBE2L6
ubiquitin conjugating enzyme E2 L6
chr2_-_162318475 3.59 ENST00000648433.1
IFIH1
interferon induced with helicase C domain 1
chr2_+_6865557 3.58 ENST00000680607.1
ENST00000680320.1
ENST00000442639.6
RSAD2
radical S-adenosyl methionine domain containing 2
chr1_+_159009886 3.57 ENST00000340979.10
ENST00000368131.8
ENST00000295809.12
ENST00000368132.7
IFI16
interferon gamma inducible protein 16
chr3_-_142448028 3.55 ENST00000392981.7
XRN1
5'-3' exoribonuclease 1
chr2_-_162318613 3.54 ENST00000649979.2
ENST00000421365.2
IFIH1
interferon induced with helicase C domain 1
chr6_-_46921926 3.51 ENST00000283296.12
ADGRF5
adhesion G protein-coupled receptor F5
chr12_-_56360084 3.49 ENST00000314128.9
ENST00000557235.5
ENST00000651915.1
STAT2
signal transducer and activator of transcription 2
chr11_-_86672114 3.47 ENST00000393324.7
ME3
malic enzyme 3
chr6_+_106098933 3.47 ENST00000369089.3
PRDM1
PR/SET domain 1
chr17_-_4263847 3.46 ENST00000570535.5
ENST00000574367.5
ENST00000341657.9
ANKFY1
ankyrin repeat and FYVE domain containing 1
chr17_+_43211835 3.26 ENST00000588693.5
ENST00000588659.5
ENST00000541594.5
ENST00000536052.5
ENST00000612339.4
TMEM106A
transmembrane protein 106A
chrX_+_37780049 3.22 ENST00000378588.5
CYBB
cytochrome b-245 beta chain
chr1_+_162632454 3.06 ENST00000367921.8
ENST00000367922.7
DDR2
discoidin domain receptor tyrosine kinase 2
chr19_+_17405685 3.01 ENST00000646744.1
ENST00000635536.2
ENST00000635060.2
ENST00000634291.2
ENST00000645298.1
ENST00000528911.5
BISPR
MVB12A
BST2 interferon stimulated positive regulator
multivesicular body subunit 12A
chr16_-_15643024 2.96 ENST00000540441.6
MARF1
meiosis regulator and mRNA stability factor 1
chr9_+_68356899 2.90 ENST00000396392.5
PGM5
phosphoglucomutase 5
chr1_+_220879434 2.81 ENST00000366903.8
HLX
H2.0 like homeobox
chr17_+_27631148 2.81 ENST00000313648.10
ENST00000395473.7
ENST00000577392.5
ENST00000584661.5
LGALS9
galectin 9
chr10_+_89414555 2.79 ENST00000371795.5
ENST00000681422.1
IFIT5
interferon induced protein with tetratricopeptide repeats 5
chr8_-_126557691 2.77 ENST00000652209.1
LRATD2
LRAT domain containing 2
chr20_-_49278034 2.75 ENST00000371744.5
ENST00000396105.6
ENST00000371752.5
ZNFX1
zinc finger NFX1-type containing 1
chr1_-_161631152 2.69 ENST00000421702.3
ENST00000650385.1
FCGR3B
Fc fragment of IgG receptor IIIb
chr12_-_121038967 2.63 ENST00000680620.1
ENST00000679655.1
ENST00000543677.2
OASL
2'-5'-oligoadenylate synthetase like
chr14_+_100065400 2.62 ENST00000555706.5
ENST00000392920.8
ENST00000555048.5
EVL
Enah/Vasp-like
chr9_-_33264559 2.61 ENST00000473781.1
ENST00000379704.7
ENST00000488499.1
BAG1
BAG cochaperone 1
chr6_+_125919296 2.59 ENST00000444128.2
NCOA7
nuclear receptor coactivator 7
chr11_-_4393650 2.57 ENST00000254436.8
TRIM21
tripartite motif containing 21
chr11_-_86672419 2.53 ENST00000524826.7
ENST00000532471.1
ME3
malic enzyme 3
chr11_+_5624987 2.49 ENST00000429814.3
TRIM34
tripartite motif containing 34
chr3_-_142448060 2.48 ENST00000264951.8
XRN1
5'-3' exoribonuclease 1
chr19_+_10111689 2.40 ENST00000321826.5
P2RY11
purinergic receptor P2Y11
chr4_+_88457110 2.38 ENST00000264350.8
HERC5
HECT and RLD domain containing E3 ubiquitin protein ligase 5
chr7_-_140062841 2.28 ENST00000263549.8
PARP12
poly(ADP-ribose) polymerase family member 12
chr6_+_72212802 2.26 ENST00000401910.7
RIMS1
regulating synaptic membrane exocytosis 1
chr6_+_125919210 2.25 ENST00000438495.6
NCOA7
nuclear receptor coactivator 7
chr2_-_151261839 2.21 ENST00000331426.6
RBM43
RNA binding motif protein 43
chr6_+_72212887 2.19 ENST00000523963.5
RIMS1
regulating synaptic membrane exocytosis 1
chr1_-_161631032 2.19 ENST00000534776.1
ENST00000613418.4
ENST00000614870.4
FCGR3B
Fc fragment of IgG receptor IIIb
chr20_-_57620467 2.17 ENST00000395822.7
ZBP1
Z-DNA binding protein 1
chr13_-_46387447 2.07 ENST00000676051.1
ENST00000378787.7
ENST00000378781.7
ENST00000378797.6
RUBCNL
rubicon like autophagy enhancer
chr14_+_22462932 2.03 ENST00000390477.2
TRDC
T cell receptor delta constant
chr4_+_159241016 2.02 ENST00000644902.1
RAPGEF2
Rap guanine nucleotide exchange factor 2
chr9_-_92536031 2.01 ENST00000344604.9
ENST00000375540.5
ECM2
extracellular matrix protein 2
chr22_+_39901075 1.96 ENST00000344138.9
GRAP2
GRB2 related adaptor protein 2
chr13_-_40982880 1.95 ENST00000635415.1
ELF1
E74 like ETS transcription factor 1
chr16_+_28863812 1.90 ENST00000684370.1
SH2B1
SH2B adaptor protein 1
chr1_-_206946448 1.87 ENST00000356495.5
PIGR
polymeric immunoglobulin receptor
chr3_-_28348805 1.86 ENST00000457172.5
ENST00000479665.6
AZI2
5-azacytidine induced 2
chr2_+_6877768 1.80 ENST00000382040.4
RSAD2
radical S-adenosyl methionine domain containing 2
chr9_-_33264678 1.78 ENST00000635077.1
ENST00000634734.3
BAG1
BAG cochaperone 1
chr20_-_57620415 1.73 ENST00000371173.8
ZBP1
Z-DNA binding protein 1
chr1_+_154405193 1.62 ENST00000622330.4
ENST00000344086.8
IL6R
interleukin 6 receptor
chr4_+_87006736 1.61 ENST00000544085.6
AFF1
AF4/FMR2 family member 1
chr19_+_16143678 1.56 ENST00000613986.4
ENST00000593031.1
HSH2D
hematopoietic SH2 domain containing
chr9_+_99906646 1.55 ENST00000259400.11
ENST00000531035.5
ENST00000525640.5
ENST00000534052.1
ENST00000526607.1
STX17
syntaxin 17
chr1_+_241532121 1.49 ENST00000366558.7
KMO
kynurenine 3-monooxygenase
chr2_-_219387881 1.48 ENST00000322176.11
ENST00000273075.9
DNPEP
aspartyl aminopeptidase
chr7_+_135148041 1.40 ENST00000275767.3
TMEM140
transmembrane protein 140
chr1_+_241532370 1.33 ENST00000366559.9
ENST00000366557.8
KMO
kynurenine 3-monooxygenase
chr16_+_28950807 1.27 ENST00000564978.5
ENST00000320805.8
NFATC2IP
nuclear factor of activated T cells 2 interacting protein
chr11_-_86672630 1.15 ENST00000543262.5
ME3
malic enzyme 3
chr15_+_44711487 1.09 ENST00000544417.5
ENST00000559916.1
ENST00000648006.3
B2M
beta-2-microglobulin
chr13_-_46387724 1.09 ENST00000675585.1
RUBCNL
rubicon like autophagy enhancer
chr10_-_5978022 1.07 ENST00000525219.6
IL15RA
interleukin 15 receptor subunit alpha
chr17_-_56914032 1.06 ENST00000537230.3
ENST00000316881.9
TRIM25
tripartite motif containing 25
chrX_-_30577759 0.98 ENST00000378962.4
TASL
TLR adaptor interacting with endolysosomal SLC15A4
chr10_+_89301932 0.93 ENST00000371826.4
ENST00000679755.1
IFIT2
interferon induced protein with tetratricopeptide repeats 2
chr20_+_62804794 0.84 ENST00000290291.10
OGFR
opioid growth factor receptor
chr17_+_40140500 0.83 ENST00000264645.12
CASC3
CASC3 exon junction complex subunit
chr5_+_134526100 0.72 ENST00000395003.5
JADE2
jade family PHD finger 2
chr9_+_68356603 0.68 ENST00000396396.6
PGM5
phosphoglucomutase 5
chr4_+_87006988 0.62 ENST00000307808.10
AFF1
AF4/FMR2 family member 1
chr6_-_32838727 0.62 ENST00000652259.1
ENST00000374897.4
ENST00000620123.4
ENST00000452392.2
TAP2
ENSG00000250264.1
transporter 2, ATP binding cassette subfamily B member
novel protein, TAP2-HLA-DOB readthrough
chr18_-_69956924 0.61 ENST00000581982.5
ENST00000280200.8
CD226
CD226 molecule
chr8_+_39913881 0.58 ENST00000518237.6
IDO1
indoleamine 2,3-dioxygenase 1
chr6_+_3068487 0.49 ENST00000259808.9
RIPK1
receptor interacting serine/threonine kinase 1
chr15_-_25863304 0.43 ENST00000555815.6
ENST00000673716.1
ATP10A
ATPase phospholipid transporting 10A (putative)
chr10_-_89414458 0.42 ENST00000371837.5
LIPA
lipase A, lysosomal acid type
chr3_-_146544538 0.40 ENST00000462666.5
PLSCR1
phospholipid scramblase 1
chr6_-_110415539 0.33 ENST00000368923.8
ENST00000368924.9
DDO
D-aspartate oxidase
chr2_+_33476640 0.25 ENST00000425210.5
ENST00000444784.5
ENST00000423159.5
ENST00000403687.8
RASGRP3
RAS guanyl releasing protein 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.2 144.5 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
4.9 14.7 GO:0034769 basement membrane disassembly(GO:0034769)
3.5 10.4 GO:0035928 mitochondrial RNA 3'-end processing(GO:0000965) miRNA catabolic process(GO:0010587) rRNA import into mitochondrion(GO:0035928)
3.4 17.0 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
3.3 16.4 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
2.4 12.2 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
2.2 6.7 GO:0019075 virus maturation(GO:0019075)
1.8 5.3 GO:1901253 negative regulation of intracellular transport of viral material(GO:1901253)
1.5 6.0 GO:0071409 cellular response to cycloheximide(GO:0071409)
1.3 9.2 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
1.2 3.5 GO:1990654 regulation of extrathymic T cell differentiation(GO:0033082) sebum secreting cell proliferation(GO:1990654)
1.1 6.8 GO:0051138 regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
1.1 7.6 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
1.1 5.4 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
1.1 3.2 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
1.0 6.0 GO:0032020 ISG15-protein conjugation(GO:0032020)
1.0 4.8 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
1.0 11.6 GO:0060700 regulation of ribonuclease activity(GO:0060700)
0.9 4.4 GO:2001107 negative regulation of establishment of T cell polarity(GO:1903904) negative regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001107)
0.9 1.7 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
0.7 7.2 GO:0072592 oxygen metabolic process(GO:0072592)
0.7 6.4 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.7 2.8 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.6 2.6 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.6 1.9 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.6 1.9 GO:0044565 dendritic cell proliferation(GO:0044565)
0.6 74.2 GO:0071357 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.6 3.5 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.5 7.8 GO:0045651 positive regulation of macrophage differentiation(GO:0045651)
0.5 2.8 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.4 1.6 GO:0002384 hepatic immune response(GO:0002384)
0.3 3.5 GO:0043129 surfactant homeostasis(GO:0043129)
0.3 1.6 GO:0016240 autophagosome docking(GO:0016240)
0.3 0.6 GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.3 3.1 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.3 3.6 GO:0019388 galactose catabolic process(GO:0019388)
0.3 4.4 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.3 4.8 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.2 4.4 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.2 2.6 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.2 2.4 GO:0023041 neuronal signal transduction(GO:0023041)
0.2 1.6 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.2 0.6 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.2 7.7 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 0.3 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.1 2.0 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.1 12.4 GO:0015992 proton transport(GO:0015992)
0.1 4.1 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.1 3.0 GO:0007143 female meiotic division(GO:0007143)
0.1 4.9 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 0.8 GO:0008298 intracellular mRNA localization(GO:0008298)
0.1 0.7 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.1 1.1 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.1 0.8 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 2.5 GO:0070206 protein trimerization(GO:0070206)
0.0 3.7 GO:0032481 positive regulation of type I interferon production(GO:0032481)
0.0 3.7 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 10.1 GO:0006836 neurotransmitter transport(GO:0006836)
0.0 2.0 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 2.0 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 1.9 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 2.0 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.4 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 0.4 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.0 2.8 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 14.7 GO:0036021 endolysosome lumen(GO:0036021)
0.9 10.4 GO:0042788 polysomal ribosome(GO:0042788)
0.7 6.7 GO:0000813 ESCRT I complex(GO:0000813)
0.5 3.5 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.4 4.4 GO:0060171 stereocilium membrane(GO:0060171)
0.3 21.5 GO:0005643 nuclear pore(GO:0005643)
0.3 1.6 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.2 108.0 GO:0031965 nuclear membrane(GO:0031965)
0.2 1.1 GO:0031905 early endosome lumen(GO:0031905)
0.2 2.8 GO:0008385 IkappaB kinase complex(GO:0008385)
0.2 3.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.2 2.0 GO:0005614 interstitial matrix(GO:0005614)
0.2 0.6 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.2 1.6 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 10.1 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 7.2 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 3.6 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 4.4 GO:0048786 presynaptic active zone(GO:0048786)
0.1 6.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 12.1 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.1 5.4 GO:0005811 lipid particle(GO:0005811)
0.1 8.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 25.3 GO:0016607 nuclear speck(GO:0016607)
0.0 3.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 7.4 GO:0005923 bicellular tight junction(GO:0005923)
0.0 2.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 4.1 GO:0043209 myelin sheath(GO:0043209)
0.0 4.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 8.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 53.9 GO:0005739 mitochondrion(GO:0005739)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 11.0 GO:0005730 nucleolus(GO:0005730)
0.0 2.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 60.1 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
2.1 12.4 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
2.0 6.0 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
1.7 10.4 GO:0034046 poly(G) binding(GO:0034046)
1.5 7.6 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
1.4 7.2 GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) oxaloacetate decarboxylase activity(GO:0008948)
1.2 6.0 GO:0042296 ISG15 transferase activity(GO:0042296)
0.9 2.8 GO:0048030 disaccharide binding(GO:0048030)
0.9 1.9 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.7 2.0 GO:0070052 collagen V binding(GO:0070052)
0.6 3.6 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.6 6.8 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.5 1.6 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.5 3.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.5 14.7 GO:0001968 fibronectin binding(GO:0001968)
0.4 144.5 GO:0008017 microtubule binding(GO:0008017)
0.3 4.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.3 11.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 4.9 GO:0019864 IgG binding(GO:0019864)
0.3 2.4 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.2 31.7 GO:0003727 single-stranded RNA binding(GO:0003727)
0.2 5.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 2.8 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.2 0.6 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.2 3.2 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor(GO:0050664)
0.1 2.0 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 2.6 GO:0005522 profilin binding(GO:0005522)
0.1 4.4 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 5.4 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 12.3 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 1.1 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 3.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.7 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1 0.4 GO:0004771 sterol esterase activity(GO:0004771)
0.1 4.8 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 0.6 GO:0023029 MHC class Ib protein binding(GO:0023029)
0.1 12.6 GO:0001047 core promoter binding(GO:0001047)
0.1 9.8 GO:0017124 SH3 domain binding(GO:0017124)
0.1 0.8 GO:0004985 opioid receptor activity(GO:0004985)
0.0 5.4 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 2.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 1.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.5 GO:0070513 death domain binding(GO:0070513)
0.0 10.1 GO:0005525 GTP binding(GO:0005525)
0.0 3.5 GO:1901981 phosphatidylinositol phosphate binding(GO:1901981)
0.0 20.8 GO:0008270 zinc ion binding(GO:0008270)
0.0 4.4 GO:0044325 ion channel binding(GO:0044325)
0.0 0.3 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.3 GO:0019992 diacylglycerol binding(GO:0019992)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 13.3 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 1.6 ST STAT3 PATHWAY STAT3 Pathway
0.1 8.2 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 7.6 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.1 16.8 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 7.4 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 7.3 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 2.0 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 6.3 PID AP1 PATHWAY AP-1 transcription factor network
0.1 14.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.8 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 3.2 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 3.2 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 1.9 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 1.9 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.5 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 15.8 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
2.2 246.9 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.8 13.4 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.5 3.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.3 6.0 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.3 4.3 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.2 4.4 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.2 1.6 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.2 4.1 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.2 12.4 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 6.0 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 4.1 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 2.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 7.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 4.6 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 3.2 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 1.9 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 6.4 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.0 0.6 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 4.8 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation