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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for IRX2
Z-value: 0.58
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Transcription factors associated with IRX2
Network of associatons between targets according to the STRING database.
First level regulatory network of IRX2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_58353069 Show fit | 14.07 |
ENST00000580947.1
|
SPT4 homolog, DSIF elongation factor subunit |
|
| chr5_+_168486462 Show fit | 9.54 |
ENST00000231572.8
ENST00000626454.1 |
arginyl-tRNA synthetase 1 |
|
| chr2_+_27628996 Show fit | 9.02 |
ENST00000616939.4
ENST00000264718.7 ENST00000610189.2 |
GPN-loop GTPase 1 |
|
| chr6_+_24774925 Show fit | 8.58 |
ENST00000356509.7
ENST00000230056.8 |
geminin DNA replication inhibitor |
|
| chr12_-_102120065 Show fit | 8.26 |
ENST00000552283.6
ENST00000551744.2 |
nucleoporin 37 |
|
| chr7_+_16661182 Show fit | 7.97 |
ENST00000446596.5
ENST00000452975.6 ENST00000438834.5 |
basic leucine zipper and W2 domains 2 |
|
| chr3_-_185923893 Show fit | 7.84 |
ENST00000259043.11
|
transformer 2 beta homolog |
|
| chr18_-_36122110 Show fit | 7.22 |
ENST00000586829.1
|
solute carrier family 39 member 6 |
|
| chr17_+_36486629 Show fit | 6.67 |
ENST00000619730.4
|
zinc finger HIT-type containing 3 |
|
| chr4_-_70839343 Show fit | 6.26 |
ENST00000514161.5
ENST00000499044.6 |
G-rich RNA sequence binding factor 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 14.1 | GO:0034244 | negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244) |
| 3.0 | 9.0 | GO:0044376 | RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022) |
| 0.9 | 8.9 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
| 1.7 | 8.6 | GO:0071163 | DNA replication preinitiation complex assembly(GO:0071163) |
| 0.2 | 8.6 | GO:0006409 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.6 | 7.8 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.8 | 7.2 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.1 | 6.3 | GO:0006378 | mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631) |
| 0.3 | 5.8 | GO:0090084 | negative regulation of inclusion body assembly(GO:0090084) |
| 1.9 | 5.7 | GO:2000863 | positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 14.1 | GO:0032044 | DSIF complex(GO:0032044) |
| 0.1 | 9.4 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.7 | 8.9 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.0 | 8.6 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.5 | 8.3 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.1 | 7.2 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 6.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 6.3 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.6 | 5.8 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.0 | 5.7 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 14.1 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.3 | 12.5 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.0 | 9.0 | GO:0003924 | GTPase activity(GO:0003924) |
| 2.2 | 8.9 | GO:0004739 | pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739) |
| 0.1 | 8.6 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.0 | 8.0 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.2 | 7.8 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.3 | 7.2 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 6.6 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.6 | 4.8 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.7 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 5.8 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 5.8 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 3.9 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 2.1 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 2.0 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 1.9 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 1.6 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.0 | 1.0 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 0.6 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 14.1 | REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT | Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat |
| 0.3 | 12.0 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.5 | 8.9 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.5 | 8.6 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 0.4 | 7.2 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 6.3 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.0 | 5.7 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.2 | 5.6 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 4.8 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 3.9 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |