Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for IRX3
Z-value: 1.36
Motif logo
Transcription factors associated with IRX3
Network of associatons between targets according to the STRING database.
First level regulatory network of IRX3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_91179517 Show fit | 44.52 |
ENST00000551354.1
|
decorin |
|
| chr12_-_91179355 Show fit | 41.87 |
ENST00000550563.5
ENST00000546370.5 |
decorin |
|
| chr12_-_91180365 Show fit | 38.27 |
ENST00000547937.5
|
decorin |
|
| chr12_-_91179472 Show fit | 37.50 |
ENST00000550099.5
ENST00000546391.5 |
decorin |
|
| chr5_+_55024250 Show fit | 22.89 |
ENST00000231009.3
|
granzyme K |
|
| chr9_-_90642855 Show fit | 22.40 |
ENST00000637905.1
|
DIRAS family GTPase 2 |
|
| chr6_-_107824294 Show fit | 22.16 |
ENST00000369020.8
ENST00000369022.6 |
Scm polycomb group protein like 4 |
|
| chr4_-_87529359 Show fit | 22.12 |
ENST00000458304.2
ENST00000282470.11 |
SPARC like 1 |
|
| chr12_-_91153149 Show fit | 21.29 |
ENST00000550758.1
|
decorin |
|
| chr1_+_116754422 Show fit | 20.40 |
ENST00000369478.4
ENST00000369477.1 |
CD2 molecule |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.6 | 189.2 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.8 | 80.1 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.8 | 77.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.9 | 68.1 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 1.1 | 43.4 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 1.7 | 26.5 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
| 1.9 | 24.5 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
| 0.1 | 24.1 | GO:0002250 | adaptive immune response(GO:0002250) |
| 1.5 | 21.7 | GO:0045059 | positive thymic T cell selection(GO:0045059) |
| 2.9 | 20.4 | GO:0030885 | regulation of myeloid dendritic cell activation(GO:0030885) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 198.4 | GO:0005615 | extracellular space(GO:0005615) |
| 14.1 | 183.5 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 90.3 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.2 | 55.7 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 1.0 | 50.4 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 1.0 | 47.6 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.2 | 23.3 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 2.0 | 21.7 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.1 | 20.5 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.5 | 20.4 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 205.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.6 | 108.0 | GO:0003823 | antigen binding(GO:0003823) |
| 0.7 | 66.8 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.8 | 50.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 43.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.4 | 38.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.4 | 26.5 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.0 | 24.4 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 22.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 3.9 | 19.4 | GO:0004826 | phenylalanine-tRNA ligase activity(GO:0004826) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 189.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.3 | 88.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 73.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 47.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.5 | 23.0 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.4 | 23.0 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.2 | 21.0 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 1.1 | 19.3 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.8 | 17.6 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.3 | 16.7 | NABA COLLAGENS | Genes encoding collagen proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.3 | 171.1 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.7 | 60.2 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.3 | 29.3 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.7 | 27.7 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.1 | 27.0 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 1.1 | 21.7 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.5 | 17.8 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.3 | 17.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 17.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.4 | 16.7 | REACTOME AMYLOIDS | Genes involved in Amyloids |