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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for IRX6_IRX4

Z-value: 0.48

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Transcription factors associated with IRX6_IRX4

Gene Symbol Gene ID Gene Info
IRX6
ENSG00000159387.8 IRX6
IRX4
ENSG00000113430.10 IRX4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX4hg38_v1_chr5_-_1886938_1886984,
hg38_v1_chr5_-_1882902_1882932		-0.454.7e-12Click!

Activity profile of IRX6_IRX4 motif

Sorted Z-values of IRX6_IRX4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX6_IRX4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr13_-_46142834 19.50 ENST00000674665.1
LCP1
lymphocyte cytosolic protein 1
chr1_+_220094086 15.66 ENST00000366922.3
IARS2
isoleucyl-tRNA synthetase 2, mitochondrial
chr15_-_63156774 11.00 ENST00000462430.5
RPS27L
ribosomal protein S27 like
chr14_-_21269392 8.43 ENST00000554891.5
ENST00000555883.5
ENST00000553753.5
ENST00000555914.5
ENST00000557336.1
ENST00000555215.5
ENST00000556628.5
ENST00000555137.5
ENST00000556226.5
ENST00000555309.5
ENST00000556142.5
ENST00000554969.5
ENST00000554455.5
ENST00000556513.5
ENST00000557201.5
ENST00000420743.6
ENST00000557768.1
ENST00000553300.6
ENST00000554383.5
ENST00000554539.5
HNRNPC
heterogeneous nuclear ribonucleoprotein C
chr12_-_76068933 8.13 ENST00000552056.5
NAP1L1
nucleosome assembly protein 1 like 1
chr15_+_88635626 8.11 ENST00000379224.10
ISG20
interferon stimulated exonuclease gene 20
chr14_+_55661272 6.99 ENST00000555573.5
KTN1
kinectin 1
chr1_-_3650063 6.61 ENST00000419924.2
ENST00000270708.12
WRAP73
WD repeat containing, antisense to TP73
chr7_-_16804987 4.48 ENST00000401412.5
ENST00000419304.7
AGR2
anterior gradient 2, protein disulphide isomerase family member
chr1_+_26317950 3.73 ENST00000374213.3
CD52
CD52 molecule
chr9_-_41189310 3.71 ENST00000456520.5
ENST00000377391.8
ENST00000613716.4
ENST00000617933.1
CBWD6
COBW domain containing 6
chr14_-_23154369 3.52 ENST00000453702.5
SLC7A8
solute carrier family 7 member 8
chr12_+_53454764 3.49 ENST00000439930.7
ENST00000548933.5
PCBP2
poly(rC) binding protein 2
chrX_+_49529869 3.43 ENST00000361446.5
GAGE12B
G antigen 12B
chr17_-_49646581 3.41 ENST00000510476.5
ENST00000503676.5
SPOP
speckle type BTB/POZ protein
chr9_+_68241854 3.24 ENST00000616550.4
ENST00000618217.4
ENST00000377342.9
ENST00000478048.5
ENST00000360171.11
CBWD3
COBW domain containing 3
chr4_-_103198331 3.20 ENST00000265148.9
ENST00000514974.1
CENPE
centromere protein E
chr9_+_65675834 3.13 ENST00000377392.9
ENST00000377384.5
ENST00000430059.6
ENST00000429800.6
ENST00000382405.8
ENST00000377395.8
CBWD5
COBW domain containing 5
chr1_-_38881587 3.13 ENST00000357771.5
ENST00000621281.1
GJA9
ENSG00000274944.4
gap junction protein alpha 9
novel protein
chr12_-_123633604 3.00 ENST00000534960.5
ENST00000424014.7
EIF2B1
eukaryotic translation initiation factor 2B subunit alpha
chr4_-_103198371 2.92 ENST00000611174.4
ENST00000380026.8
CENPE
centromere protein E
chr2_+_159733958 2.92 ENST00000409591.5
MARCHF7
membrane associated ring-CH-type finger 7
chr4_+_112637456 2.61 ENST00000505034.5
ENST00000324052.10
LARP7
La ribonucleoprotein 7, transcriptional regulator
chr12_-_31792290 2.61 ENST00000340398.5
H3-5
H3.5 histone
chr4_+_40193642 2.50 ENST00000617441.4
ENST00000503941.5
RHOH
ras homolog family member H
chr18_-_36798482 2.48 ENST00000590258.2
TPGS2
tubulin polyglutamylase complex subunit 2
chr4_+_112637514 2.36 ENST00000651579.1
LARP7
La ribonucleoprotein 7, transcriptional regulator
chr17_-_31314040 2.14 ENST00000330927.5
EVI2B
ecotropic viral integration site 2B
chr3_-_27456743 2.11 ENST00000295736.9
ENST00000428386.5
ENST00000428179.1
SLC4A7
solute carrier family 4 member 7
chr14_-_106154113 1.89 ENST00000390603.2
IGHV3-15
immunoglobulin heavy variable 3-15
chr3_-_169147734 1.50 ENST00000464456.5
MECOM
MDS1 and EVI1 complex locus
chr22_-_23754376 1.43 ENST00000398465.3
ENST00000248948.4
VPREB3
V-set pre-B cell surrogate light chain 3
chr5_+_93583212 1.18 ENST00000327111.8
NR2F1
nuclear receptor subfamily 2 group F member 1
chr13_+_111186773 1.03 ENST00000426073.6
ARHGEF7
Rho guanine nucleotide exchange factor 7
chr2_-_39121000 0.96 ENST00000402219.8
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1
chr10_+_84424919 0.91 ENST00000543283.2
ENST00000494586.5
CCSER2
coiled-coil serine rich protein 2
chr22_+_24270776 0.73 ENST00000437398.5
ENST00000421374.5
ENST00000314328.14
ENST00000651059.1
ENST00000541492.1
SPECC1L
sperm antigen with calponin homology and coiled-coil domains 1 like
chr14_+_22524325 0.69 ENST00000390517.1
TRAJ20
T cell receptor alpha joining 20
chr4_-_142560669 0.67 ENST00000510812.5
INPP4B
inositol polyphosphate-4-phosphatase type II B
chr1_-_115841116 0.57 ENST00000320238.3
NHLH2
nescient helix-loop-helix 2
chr10_+_116591010 0.52 ENST00000530319.5
ENST00000527980.5
ENST00000471549.5
ENST00000534537.5
PNLIPRP1
pancreatic lipase related protein 1
chr10_+_116590956 0.47 ENST00000358834.9
ENST00000528052.5
PNLIPRP1
pancreatic lipase related protein 1
chr15_+_66293217 0.44 ENST00000319194.9
ENST00000525134.6
DIS3L
DIS3 like exosome 3'-5' exoribonuclease
chrX_+_100644183 0.41 ENST00000640889.1
ENST00000373004.5
SRPX2
sushi repeat containing protein X-linked 2
chr8_+_67064316 0.32 ENST00000675306.2
ENST00000678017.1
ENST00000262210.11
ENST00000675869.1
ENST00000677009.1
ENST00000676847.1
ENST00000676471.1
ENST00000678542.1
ENST00000677619.1
ENST00000676605.1
ENST00000678553.1
ENST00000674993.1
ENST00000678318.1
ENST00000676573.1
ENST00000676317.1
ENST00000677592.1
ENST00000679226.1
ENST00000675955.1
ENST00000676882.1
ENST00000678616.1
ENST00000678645.1
ENST00000678747.1
CSPP1
centrosome and spindle pole associated protein 1
chr14_+_21918161 0.22 ENST00000390439.2
TRAV13-2
T cell receptor alpha variable 13-2
chr21_-_32813679 0.20 ENST00000487113.1
ENST00000382373.4
C21orf62
chromosome 21 open reading frame 62
chr12_-_10130143 0.16 ENST00000298523.9
ENST00000396484.6
ENST00000310002.4
ENST00000304084.13
CLEC7A
C-type lectin domain containing 7A
chr15_+_66293541 0.15 ENST00000319212.9
ENST00000525109.1
DIS3L
DIS3 like exosome 3'-5' exoribonuclease
chr19_+_54497879 0.14 ENST00000412608.5
ENST00000610651.1
LAIR2
leukocyte associated immunoglobulin like receptor 2
chr2_+_225399684 0.11 ENST00000636099.1
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chrX_+_22136552 0.10 ENST00000682888.1
ENST00000684356.1
PHEX
phosphate regulating endopeptidase homolog X-linked
chr5_+_55024250 0.08 ENST00000231009.3
GZMK
granzyme K

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.1 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
1.2 15.7 GO:0006450 regulation of translational fidelity(GO:0006450)
1.0 6.1 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
1.0 19.5 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.9 4.5 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.7 6.6 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.6 3.4 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.5 11.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.4 8.4 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.2 3.5 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.2 1.0 GO:1904693 midbrain morphogenesis(GO:1904693)
0.1 3.7 GO:0045730 respiratory burst(GO:0045730)
0.1 1.0 GO:1904424 regulation of GTP binding(GO:1904424)
0.1 2.1 GO:0060117 auditory receptor cell development(GO:0060117)
0.1 8.1 GO:0006334 nucleosome assembly(GO:0006334)
0.1 1.8 GO:0015695 organic cation transport(GO:0015695)
0.0 3.0 GO:0014003 oligodendrocyte development(GO:0014003)
0.0 1.5 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.4 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.6 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 2.0 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.1 GO:1904383 response to sodium phosphate(GO:1904383)
0.0 7.0 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.6 GO:0044705 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 1.4 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 0.9 GO:0001578 microtubule bundle formation(GO:0001578)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 19.5 GO:0001891 phagocytic cup(GO:0001891)
0.5 6.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.4 3.0 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.2 8.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.2 3.1 GO:0005922 connexon complex(GO:0005922)
0.2 11.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 8.1 GO:0015030 Cajal body(GO:0015030)
0.1 1.0 GO:0000322 storage vacuole(GO:0000322)
0.1 6.6 GO:0036064 ciliary basal body(GO:0036064)
0.1 0.7 GO:0005921 gap junction(GO:0005921)
0.1 3.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 2.1 GO:0032420 stereocilium(GO:0032420)
0.0 8.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.6 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 15.0 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 1.4 GO:0001772 immunological synapse(GO:0001772)
0.0 3.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 6.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 8.5 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.1 GO:0008859 exoribonuclease II activity(GO:0008859)
2.6 15.7 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
1.5 6.1 GO:0043515 kinetochore binding(GO:0043515)
0.7 8.4 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.5 11.0 GO:0008494 translation activator activity(GO:0008494)
0.4 3.5 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.2 4.5 GO:0002162 dystroglycan binding(GO:0002162)
0.1 1.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 0.7 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.1 1.8 GO:0019534 toxin transporter activity(GO:0019534)
0.1 2.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 7.0 GO:0019894 kinesin binding(GO:0019894)
0.1 18.9 GO:0051015 actin filament binding(GO:0051015)
0.1 1.4 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 3.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.0 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 1.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 1.5 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 4.0 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.6 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 2.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 8.4 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 11.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 3.4 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 2.7 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.0 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.0 PID AURORA A PATHWAY Aurora A signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 15.7 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.2 3.1 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 8.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 11.9 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.0 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 1.8 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.7 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 1.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway