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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for IRX6_IRX4
Z-value: 0.48
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Transcription factors associated with IRX6_IRX4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRX4 | hg38_v1_chr5_-_1886938_1886984, hg38_v1_chr5_-_1882902_1882932 | -0.45 | 4.7e-12 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRX6_IRX4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 19.5 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 1.2 | 15.7 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
| 0.5 | 11.0 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.4 | 8.4 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 2.7 | 8.1 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.1 | 8.1 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.0 | 7.0 | GO:0007018 | microtubule-based movement(GO:0007018) |
| 0.7 | 6.6 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 1.0 | 6.1 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 0.9 | 4.5 | GO:0060480 | lung goblet cell differentiation(GO:0060480) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 19.5 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 15.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 11.0 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 8.5 | GO:0030529 | intracellular ribonucleoprotein complex(GO:0030529) |
| 0.2 | 8.4 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.1 | 8.1 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 8.1 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 6.6 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.5 | 6.1 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 6.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.9 | GO:0051015 | actin filament binding(GO:0051015) |
| 2.6 | 15.7 | GO:0002161 | aminoacyl-tRNA editing activity(GO:0002161) |
| 0.5 | 11.0 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.7 | 8.4 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 2.7 | 8.1 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.1 | 7.0 | GO:0019894 | kinesin binding(GO:0019894) |
| 1.5 | 6.1 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.2 | 4.5 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 4.0 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.4 | 3.5 | GO:1990829 | C-rich single-stranded DNA binding(GO:1990829) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 8.4 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 3.4 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 2.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.0 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 1.0 | PID AURORA A PATHWAY | Aurora A signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 15.7 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.1 | 11.9 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 8.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.2 | 3.1 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 1.8 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 1.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.0 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 0.7 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |