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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ISL1
Z-value: 1.26
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Transcription factors associated with ISL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ISL1 | hg38_v1_chr5_+_51383394_51383454 | -0.06 | 4.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ISL1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_174846405 Show fit | 63.53 |
ENST00000409597.5
ENST00000413882.6 |
chimerin 1 |
|
| chr4_-_176002332 Show fit | 35.32 |
ENST00000280187.11
ENST00000512509.5 |
glycoprotein M6A |
|
| chr12_-_49897056 Show fit | 26.57 |
ENST00000552863.5
|
Fas apoptotic inhibitory molecule 2 |
|
| chr5_+_141370236 Show fit | 26.48 |
ENST00000576222.2
ENST00000618934.1 |
protocadherin gamma subfamily B, 3 |
|
| chr14_-_59870752 Show fit | 25.25 |
ENST00000611068.1
ENST00000267484.10 |
reticulon 1 |
|
| chr2_-_174847015 Show fit | 24.82 |
ENST00000650938.1
|
chimerin 1 |
|
| chr1_-_156248084 Show fit | 24.13 |
ENST00000652405.1
ENST00000335852.6 ENST00000540423.5 ENST00000612424.4 ENST00000613336.4 ENST00000623241.3 |
progestin and adipoQ receptor family member 6 |
|
| chr6_-_52840843 Show fit | 22.26 |
ENST00000370989.6
|
glutathione S-transferase alpha 5 |
|
| chr1_-_156248013 Show fit | 22.15 |
ENST00000368270.2
|
progestin and adipoQ receptor family member 6 |
|
| chr18_-_24397784 Show fit | 21.85 |
ENST00000399441.4
ENST00000319481.8 |
oxysterol binding protein like 1A |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 88.3 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.4 | 70.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.2 | 69.8 | GO:0043401 | steroid hormone mediated signaling pathway(GO:0043401) |
| 1.4 | 52.0 | GO:0050650 | chondroitin sulfate proteoglycan biosynthetic process(GO:0050650) |
| 4.7 | 42.0 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
| 12.3 | 36.8 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.8 | 35.3 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.5 | 33.5 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.8 | 32.5 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 2.1 | 32.1 | GO:0007258 | JUN phosphorylation(GO:0007258) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 84.9 | GO:0016021 | integral component of membrane(GO:0016021) |
| 2.1 | 42.0 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.2 | 42.0 | GO:0030018 | Z disc(GO:0030018) |
| 7.4 | 36.9 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.1 | 36.1 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 1.4 | 35.3 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.2 | 22.6 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.4 | 22.3 | GO:0043034 | costamere(GO:0043034) |
| 1.0 | 21.8 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.8 | 21.2 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 88.3 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.1 | 82.9 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.5 | 69.8 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.8 | 47.1 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.2 | 37.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 37.4 | GO:0044325 | ion channel binding(GO:0044325) |
| 9.2 | 36.8 | GO:0015018 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018) |
| 7.4 | 36.8 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.3 | 35.3 | GO:0005262 | calcium channel activity(GO:0005262) |
| 1.3 | 32.5 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 88.3 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 1.1 | 70.6 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.4 | 26.6 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.3 | 24.9 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.3 | 15.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 14.5 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.1 | 14.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 9.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 9.1 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 7.8 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 88.3 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.3 | 52.0 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 1.7 | 36.8 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 1.1 | 32.1 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.9 | 29.8 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.6 | 24.9 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 18.4 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.2 | 16.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.4 | 10.6 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 10.1 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |