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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ISL1

Z-value: 1.26

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Transcription factors associated with ISL1

Gene Symbol Gene ID Gene Info
ISL1
ENSG00000016082.15 ISL1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ISL1hg38_v1_chr5_+_51383394_51383454-0.064.0e-01Click!

Activity profile of ISL1 motif

Sorted Z-values of ISL1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_-_174846405 63.53 ENST00000409597.5
ENST00000413882.6
CHN1
chimerin 1
chr4_-_176002332 35.32 ENST00000280187.11
ENST00000512509.5
GPM6A
glycoprotein M6A
chr12_-_49897056 26.57 ENST00000552863.5
FAIM2
Fas apoptotic inhibitory molecule 2
chr5_+_141370236 26.48 ENST00000576222.2
ENST00000618934.1
PCDHGB3
protocadherin gamma subfamily B, 3
chr14_-_59870752 25.25 ENST00000611068.1
ENST00000267484.10
RTN1
reticulon 1
chr2_-_174847015 24.82 ENST00000650938.1
CHN1
chimerin 1
chr1_-_156248084 24.13 ENST00000652405.1
ENST00000335852.6
ENST00000540423.5
ENST00000612424.4
ENST00000613336.4
ENST00000623241.3
PAQR6
progestin and adipoQ receptor family member 6
chr6_-_52840843 22.26 ENST00000370989.6
GSTA5
glutathione S-transferase alpha 5
chr1_-_156248013 22.15 ENST00000368270.2
PAQR6
progestin and adipoQ receptor family member 6
chr18_-_24397784 21.85 ENST00000399441.4
ENST00000319481.8
OSBPL1A
oxysterol binding protein like 1A
chr1_-_156248038 20.81 ENST00000470198.5
ENST00000292291.10
ENST00000356983.7
PAQR6
progestin and adipoQ receptor family member 6
chr12_+_78864768 19.65 ENST00000261205.9
ENST00000457153.6
SYT1
synaptotagmin 1
chr16_+_7332839 18.65 ENST00000355637.9
RBFOX1
RNA binding fox-1 homolog 1
chr11_-_134412234 18.58 ENST00000312527.9
B3GAT1
beta-1,3-glucuronyltransferase 1
chr2_-_223602284 18.58 ENST00000421386.1
ENST00000305409.3
ENST00000433889.1
SCG2
secretogranin II
chrX_+_55452119 18.48 ENST00000342972.3
MAGEH1
MAGE family member H1
chr11_-_134411854 18.19 ENST00000392580.5
B3GAT1
beta-1,3-glucuronyltransferase 1
chr14_-_100569780 17.85 ENST00000355173.7
BEGAIN
brain enriched guanylate kinase associated
chr5_+_140841183 17.83 ENST00000378123.4
ENST00000531613.2
PCDHA8
protocadherin alpha 8
chr8_+_22053543 17.62 ENST00000519850.5
ENST00000381470.7
DMTN
dematin actin binding protein
chr4_-_185956652 17.28 ENST00000355634.9
SORBS2
sorbin and SH3 domain containing 2
chr12_+_78863962 17.11 ENST00000393240.7
SYT1
synaptotagmin 1
chr6_-_116254063 16.65 ENST00000420283.3
TSPYL4
TSPY like 4
chr2_+_172860038 16.39 ENST00000538974.5
ENST00000540783.5
RAPGEF4
Rap guanine nucleotide exchange factor 4
chr3_+_35679614 16.35 ENST00000474696.5
ENST00000412048.5
ENST00000396482.6
ENST00000432682.5
ARPP21
cAMP regulated phosphoprotein 21
chr18_-_5543988 16.00 ENST00000341928.7
EPB41L3
erythrocyte membrane protein band 4.1 like 3
chr15_+_80404320 15.90 ENST00000303329.9
ENST00000622346.4
ARNT2
aryl hydrocarbon receptor nuclear translocator 2
chr2_+_95025700 15.86 ENST00000309988.9
ENST00000353004.7
ENST00000354078.7
ENST00000349807.3
MAL
mal, T cell differentiation protein
chr12_-_91180365 15.26 ENST00000547937.5
DCN
decorin
chr4_-_185956348 15.25 ENST00000431902.5
ENST00000284776.11
ENST00000415274.5
SORBS2
sorbin and SH3 domain containing 2
chr5_+_174045673 15.21 ENST00000303177.8
ENST00000519867.5
NSG2
neuronal vesicle trafficking associated 2
chr9_-_110999458 14.46 ENST00000374430.6
LPAR1
lysophosphatidic acid receptor 1
chr18_-_5543960 13.60 ENST00000400111.8
EPB41L3
erythrocyte membrane protein band 4.1 like 3
chr3_+_159069252 13.12 ENST00000640015.1
ENST00000476809.7
ENST00000485419.7
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr18_-_5544250 12.43 ENST00000540638.6
ENST00000342933.7
EPB41L3
erythrocyte membrane protein band 4.1 like 3
chr4_+_113049479 12.12 ENST00000671727.1
ENST00000671762.1
ENST00000672366.1
ENST00000672502.1
ENST00000672045.1
ENST00000672251.1
ENST00000672854.1
ANK2
ankyrin 2
chr5_-_138875290 12.11 ENST00000521094.2
ENST00000274711.7
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr15_+_28885955 12.07 ENST00000558402.5
ENST00000683413.1
ENST00000558330.5
APBA2
amyloid beta precursor protein binding family A member 2
chr17_-_55511434 11.73 ENST00000636752.1
SMIM36
small integral membrane protein 36
chr4_-_86360039 11.32 ENST00000515650.2
ENST00000641724.1
ENST00000641607.1
ENST00000641324.1
ENST00000641903.1
ENST00000395157.9
ENST00000641823.1
ENST00000641873.1
ENST00000641102.1
ENST00000641462.2
ENST00000641217.1
ENST00000642006.1
ENST00000641020.1
ENST00000641110.1
ENST00000639175.1
ENST00000641485.1
ENST00000641864.1
ENST00000641954.1
ENST00000641647.1
ENST00000641459.1
ENST00000641762.1
ENST00000641777.1
ENST00000641208.1
ENST00000642015.1
ENST00000641493.1
ENST00000642032.1
ENST00000641010.1
ENST00000641287.1
ENST00000641943.1
ENST00000642103.1
ENST00000641047.1
ENST00000641166.1
ENST00000641207.1
MAPK10
mitogen-activated protein kinase 10
chr4_-_86360010 11.25 ENST00000641911.1
ENST00000641072.1
ENST00000359221.8
ENST00000640490.1
MAPK10
mitogen-activated protein kinase 10
chr22_+_39994926 10.30 ENST00000333407.11
FAM83F
family with sequence similarity 83 member F
chr4_+_113049616 10.23 ENST00000504454.5
ENST00000357077.9
ENST00000394537.7
ENST00000672779.1
ENST00000264366.10
ANK2
ankyrin 2
chrX_+_136197039 9.94 ENST00000370683.6
FHL1
four and a half LIM domains 1
chr5_+_140868945 9.83 ENST00000398640.7
PCDHA11
protocadherin alpha 11
chr4_-_86360071 9.53 ENST00000641677.1
ENST00000639234.1
ENST00000641553.1
ENST00000641826.1
ENST00000641537.1
ENST00000395169.9
ENST00000641408.1
ENST00000638225.1
ENST00000641052.1
MAPK10
mitogen-activated protein kinase 10
chr1_-_94925759 9.43 ENST00000415017.1
ENST00000545882.5
CNN3
calponin 3
chr11_-_35360050 9.30 ENST00000644868.1
ENST00000643454.1
ENST00000646080.1
SLC1A2
solute carrier family 1 member 2
chr5_+_140875299 8.90 ENST00000613593.1
ENST00000398631.3
PCDHA12
protocadherin alpha 12
chr2_+_172928165 8.48 ENST00000535187.5
RAPGEF4
Rap guanine nucleotide exchange factor 4
chr18_-_55510753 8.27 ENST00000543082.5
TCF4
transcription factor 4
chr9_+_101185029 7.97 ENST00000395056.2
PLPPR1
phospholipid phosphatase related 1
chr1_-_113887574 7.96 ENST00000393316.8
BCL2L15
BCL2 like 15
chr4_+_61201223 7.56 ENST00000512091.6
ADGRL3
adhesion G protein-coupled receptor L3
chr1_+_248231417 7.42 ENST00000641868.1
OR2M4
olfactory receptor family 2 subfamily M member 4
chr8_-_19682576 7.35 ENST00000332246.10
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr8_-_100559702 7.35 ENST00000520311.5
ENST00000520552.5
ENST00000521345.1
ENST00000523000.5
ENST00000335659.7
ENST00000358990.3
ENST00000519597.5
ANKRD46
ankyrin repeat domain 46
chrX_+_136169624 7.28 ENST00000394153.6
FHL1
four and a half LIM domains 1
chrX_-_103686687 7.20 ENST00000441076.7
ENST00000422355.5
ENST00000442614.5
ENST00000451301.5
MORF4L2
mortality factor 4 like 2
chr9_-_14300231 7.18 ENST00000636735.1
NFIB
nuclear factor I B
chr10_-_60572599 7.12 ENST00000503366.5
ANK3
ankyrin 3
chr11_-_70717994 7.05 ENST00000659264.1
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr5_+_141397942 6.97 ENST00000617380.2
ENST00000621169.1
PCDHGB5
protocadherin gamma subfamily B, 5
chrX_+_136169833 6.88 ENST00000628032.2
FHL1
four and a half LIM domains 1
chr2_-_166149120 6.14 ENST00000641575.1
ENST00000641603.1
SCN1A
sodium voltage-gated channel alpha subunit 1
chr6_+_36885944 6.11 ENST00000480824.7
C6orf89
chromosome 6 open reading frame 89
chr18_-_55423757 6.09 ENST00000675707.1
TCF4
transcription factor 4
chr2_-_166149204 6.00 ENST00000635750.1
SCN1A
sodium voltage-gated channel alpha subunit 1
chr8_+_38728186 5.87 ENST00000519416.5
ENST00000520615.5
TACC1
transforming acidic coiled-coil containing protein 1
chrX_+_136169891 5.65 ENST00000449474.5
FHL1
four and a half LIM domains 1
chr16_+_47462112 5.47 ENST00000567200.1
PHKB
phosphorylase kinase regulatory subunit beta
chrX_-_72306962 5.25 ENST00000246139.9
CITED1
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1
chr6_+_150683593 4.98 ENST00000644968.1
PLEKHG1
pleckstrin homology and RhoGEF domain containing G1
chr19_-_17377334 4.76 ENST00000252590.9
ENST00000599426.1
PLVAP
plasmalemma vesicle associated protein
chr5_-_95081482 4.73 ENST00000312216.12
ENST00000512425.5
ENST00000505208.5
ENST00000429576.6
ENST00000508509.5
ENST00000510732.5
MCTP1
multiple C2 and transmembrane domain containing 1
chrX_-_72307148 4.69 ENST00000453707.6
ENST00000373619.7
CITED1
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1
chr18_+_48539112 4.68 ENST00000382998.8
CTIF
cap binding complex dependent translation initiation factor
chr14_+_19743571 4.66 ENST00000642117.2
OR4Q3
olfactory receptor family 4 subfamily Q member 3
chr15_+_42359577 4.62 ENST00000357568.8
CAPN3
calpain 3
chr12_+_80716906 4.59 ENST00000228644.4
MYF5
myogenic factor 5
chr18_+_48539017 4.57 ENST00000256413.8
CTIF
cap binding complex dependent translation initiation factor
chr15_+_42359454 4.48 ENST00000349748.8
ENST00000318023.11
ENST00000397163.8
CAPN3
calpain 3
chr6_-_52763473 4.44 ENST00000493422.3
GSTA2
glutathione S-transferase alpha 2
chrY_-_6872608 4.30 ENST00000383036.1
AMELY
amelogenin Y-linked
chr16_+_2148603 4.19 ENST00000210187.11
RAB26
RAB26, member RAS oncogene family
chr13_-_108218293 4.17 ENST00000405925.2
LIG4
DNA ligase 4
chr1_-_79006773 4.17 ENST00000671209.1
ADGRL4
adhesion G protein-coupled receptor L4
chr2_+_233307806 4.15 ENST00000447536.5
ENST00000409110.6
SAG
S-antigen visual arrestin
chr1_+_100133135 4.15 ENST00000370143.5
ENST00000370141.7
TRMT13
tRNA methyltransferase 13 homolog
chr19_-_49119092 4.07 ENST00000408991.4
C19orf73
chromosome 19 open reading frame 73
chr6_+_31547560 4.06 ENST00000376148.9
ENST00000376145.8
NFKBIL1
NFKB inhibitor like 1
chr1_+_196652022 3.98 ENST00000367429.9
ENST00000630130.2
ENST00000359637.2
CFH
complement factor H
chr3_-_192727500 3.89 ENST00000430714.5
ENST00000418610.1
ENST00000445105.7
ENST00000684728.1
ENST00000448795.5
ENST00000683935.1
ENST00000684282.1
ENST00000683451.1
FGF12
fibroblast growth factor 12
chr12_+_119668109 3.80 ENST00000229328.10
ENST00000630317.1
PRKAB1
protein kinase AMP-activated non-catalytic subunit beta 1
chrX_+_136169664 3.76 ENST00000456445.5
FHL1
four and a half LIM domains 1
chr12_-_42237727 3.75 ENST00000548917.1
YAF2
YY1 associated factor 2
chr7_+_90709530 3.74 ENST00000406263.5
CDK14
cyclin dependent kinase 14
chr3_+_4680617 3.60 ENST00000648212.1
ITPR1
inositol 1,4,5-trisphosphate receptor type 1
chr16_+_55656294 3.53 ENST00000379906.6
SLC6A2
solute carrier family 6 member 2
chr1_-_79006680 3.48 ENST00000370742.4
ENST00000656841.1
ADGRL4
adhesion G protein-coupled receptor L4
chr2_-_54987578 3.44 ENST00000486085.5
RTN4
reticulon 4
chr11_-_63015804 3.43 ENST00000535878.5
ENST00000545207.5
SLC22A8
solute carrier family 22 member 8
chr21_-_46155567 3.31 ENST00000291670.9
ENST00000397748.5
ENST00000397743.1
ENST00000397746.8
FTCD
formimidoyltransferase cyclodeaminase
chr6_+_43014103 3.30 ENST00000244670.12
ENST00000326974.9
ENST00000332245.9
KLHDC3
kelch domain containing 3
chr18_+_74499861 3.14 ENST00000324301.12
CNDP2
carnosine dipeptidase 2
chr2_+_170178136 3.11 ENST00000409044.7
ENST00000408978.9
MYO3B
myosin IIIB
chr4_+_56436233 3.10 ENST00000512576.3
PAICS
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
chr7_+_90709231 3.08 ENST00000446790.5
ENST00000265741.7
CDK14
cyclin dependent kinase 14
chrX_+_51893533 3.03 ENST00000375722.5
ENST00000326587.12
ENST00000375695.2
MAGED1
MAGE family member D1
chr10_-_77637789 2.99 ENST00000481070.1
ENST00000640969.1
ENST00000286628.14
ENST00000638991.1
ENST00000639913.1
ENST00000480683.2
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr11_-_63015831 2.98 ENST00000430500.6
ENST00000336232.7
SLC22A8
solute carrier family 22 member 8
chr9_+_37667997 2.97 ENST00000539465.5
FRMPD1
FERM and PDZ domain containing 1
chr12_-_10098977 2.95 ENST00000315330.8
ENST00000457018.6
CLEC1A
C-type lectin domain family 1 member A
chr19_-_18606779 2.93 ENST00000684169.1
ENST00000392386.8
CRLF1
cytokine receptor like factor 1
chr4_+_87832917 2.86 ENST00000395102.8
ENST00000497649.6
ENST00000540395.1
ENST00000560249.5
ENST00000511670.5
ENST00000361056.3
MEPE
matrix extracellular phosphoglycoprotein
chr16_+_55656089 2.85 ENST00000414754.7
SLC6A2
solute carrier family 6 member 2
chr1_-_160285120 2.84 ENST00000368072.10
PEX19
peroxisomal biogenesis factor 19
chr8_-_12194067 2.82 ENST00000524571.6
ENST00000533852.6
ENST00000533513.1
ENST00000448228.6
ENST00000534520.5
FAM86B1
family with sequence similarity 86 member B1
chr19_+_3506251 2.81 ENST00000441788.7
FZR1
fizzy and cell division cycle 20 related 1
chr6_-_100464912 2.79 ENST00000369208.8
SIM1
SIM bHLH transcription factor 1
chr21_-_40847149 2.68 ENST00000400454.6
DSCAM
DS cell adhesion molecule
chr5_-_16508858 2.68 ENST00000684456.1
RETREG1
reticulophagy regulator 1
chr6_-_136466858 2.68 ENST00000544465.5
MAP7
microtubule associated protein 7
chr5_+_32710630 2.63 ENST00000326958.5
NPR3
natriuretic peptide receptor 3
chr7_-_108240049 2.54 ENST00000379022.8
NRCAM
neuronal cell adhesion molecule
chr10_+_122163672 2.47 ENST00000369004.7
ENST00000260733.7
TACC2
transforming acidic coiled-coil containing protein 2
chr17_+_28371656 2.44 ENST00000585482.6
SARM1
sterile alpha and TIR motif containing 1
chr7_-_78771265 2.40 ENST00000630991.2
ENST00000629359.2
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr6_+_27388748 2.31 ENST00000244576.9
ZNF391
zinc finger protein 391
chr11_+_22666604 2.29 ENST00000454584.6
GAS2
growth arrest specific 2
chr16_+_55656249 2.23 ENST00000219833.13
ENST00000574918.2
SLC6A2
solute carrier family 6 member 2
chr9_+_27109200 2.23 ENST00000380036.10
TEK
TEK receptor tyrosine kinase
chrX_-_23907887 2.16 ENST00000379226.9
APOO
apolipoprotein O
chr17_-_15598618 2.11 ENST00000583965.5
CDRT1
CMT1A duplicated region transcript 1
chr7_-_44541318 2.07 ENST00000381160.8
NPC1L1
NPC1 like intracellular cholesterol transporter 1
chr16_+_55655960 2.00 ENST00000568943.6
SLC6A2
solute carrier family 6 member 2
chr9_+_27109135 1.93 ENST00000519097.5
ENST00000615002.4
TEK
TEK receptor tyrosine kinase
chr8_+_109362453 1.93 ENST00000378402.10
PKHD1L1
PKHD1 like 1
chr5_+_175861628 1.87 ENST00000509837.5
CPLX2
complexin 2
chr10_+_133527355 1.79 ENST00000252945.8
ENST00000421586.5
ENST00000418356.1
CYP2E1
cytochrome P450 family 2 subfamily E member 1
chr11_-_75096876 1.79 ENST00000641541.1
ENST00000641593.1
ENST00000641504.1
ENST00000641931.1
ENST00000647690.1
OR2AT4
ENSG00000284722.2
olfactory receptor family 2 subfamily AT member 4
novel transcript
chrX_-_30309387 1.77 ENST00000378970.5
NR0B1
nuclear receptor subfamily 0 group B member 1
chr2_-_207165923 1.72 ENST00000309446.11
KLF7
Kruppel like factor 7
chr1_-_7940825 1.72 ENST00000377507.8
TNFRSF9
TNF receptor superfamily member 9
chr10_-_77637902 1.63 ENST00000286627.10
ENST00000639486.1
ENST00000640523.1
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr7_-_44541262 1.62 ENST00000289547.8
ENST00000546276.5
ENST00000423141.1
NPC1L1
NPC1 like intracellular cholesterol transporter 1
chr6_+_168017873 1.60 ENST00000351261.4
ENST00000354419.6
KIF25
kinesin family member 25
chr6_-_110815408 1.58 ENST00000368911.8
CDK19
cyclin dependent kinase 19
chr12_-_30735014 1.54 ENST00000433722.6
CAPRIN2
caprin family member 2
chr5_+_137867852 1.49 ENST00000421631.6
ENST00000239926.9
MYOT
myotilin
chr7_+_144070313 1.40 ENST00000641441.1
OR2A25
olfactory receptor family 2 subfamily A member 25
chr12_+_54008961 1.40 ENST00000040584.6
HOXC8
homeobox C8
chr3_+_38265802 1.34 ENST00000311856.9
SLC22A13
solute carrier family 22 member 13
chr11_+_57805541 1.16 ENST00000683201.1
ENST00000683769.1
CTNND1
catenin delta 1
chr3_-_119557728 1.14 ENST00000383669.3
CD80
CD80 molecule
chr13_-_99016034 1.12 ENST00000448493.7
DOCK9
dedicator of cytokinesis 9
chr15_+_58987652 1.00 ENST00000348370.9
ENST00000559160.1
RNF111
ring finger protein 111
chr3_+_119782094 0.95 ENST00000393716.8
NR1I2
nuclear receptor subfamily 1 group I member 2
chr1_+_197413827 0.90 ENST00000367397.1
ENST00000681519.1
CRB1
crumbs cell polarity complex component 1
chr4_+_70195719 0.84 ENST00000683306.1
ODAM
odontogenic, ameloblast associated
chr8_-_78805306 0.84 ENST00000639719.1
ENST00000263851.9
IL7
interleukin 7
chr20_+_43507668 0.83 ENST00000434666.5
ENST00000649084.1
ENST00000418998.7
ENST00000427442.8
ENST00000649917.1
L3MBTL1
L3MBTL histone methyl-lysine binding protein 1
chr17_-_66229380 0.77 ENST00000205948.11
APOH
apolipoprotein H
chr17_-_48968587 0.75 ENST00000357424.2
GIP
gastric inhibitory polypeptide
chr5_+_141213919 0.62 ENST00000341948.6
PCDHB13
protocadherin beta 13
chr11_-_18236795 0.60 ENST00000278222.7
SAA4
serum amyloid A4, constitutive
chrX_-_100874351 0.59 ENST00000372966.8
NOX1
NADPH oxidase 1
chr3_-_124887353 0.54 ENST00000296181.9
ITGB5
integrin subunit beta 5
chr9_-_92404559 0.54 ENST00000262551.8
ENST00000375561.10
OGN
osteoglycin
chr2_-_96740034 0.53 ENST00000264963.9
ENST00000377079.8
LMAN2L
lectin, mannose binding 2 like
chr6_+_31739948 0.51 ENST00000375755.8
ENST00000425703.5
ENST00000375750.9
ENST00000375703.7
ENST00000375740.7
MSH5
mutS homolog 5
chr16_+_20764036 0.49 ENST00000440284.6
ACSM3
acyl-CoA synthetase medium chain family member 3
chr18_-_13915531 0.47 ENST00000327606.4
MC2R
melanocortin 2 receptor
chrX_-_100874209 0.45 ENST00000372964.5
ENST00000217885.5
NOX1
NADPH oxidase 1
chr19_+_3506355 0.41 ENST00000652521.1
FZR1
fizzy and cell division cycle 20 related 1
chr16_-_23453136 0.38 ENST00000307149.10
COG7
component of oligomeric golgi complex 7
chr9_+_133459965 0.37 ENST00000540581.5
ENST00000542192.5
ENST00000291722.11
ENST00000316948.9
CACFD1
calcium channel flower domain containing 1
chr2_+_28395511 0.36 ENST00000436647.1
FOSL2
FOS like 2, AP-1 transcription factor subunit
chr1_+_81800368 0.29 ENST00000674489.1
ENST00000674442.1
ENST00000674419.1
ENST00000674407.1
ENST00000674168.1
ENST00000674307.1
ENST00000674209.1
ENST00000370715.5
ENST00000370713.5
ENST00000319517.10
ENST00000627151.2
ENST00000370717.6
ADGRL2
adhesion G protein-coupled receptor L2
chr8_-_132625378 0.26 ENST00000522789.5
LRRC6
leucine rich repeat containing 6
chr17_-_69244846 0.21 ENST00000269081.8
ABCA10
ATP binding cassette subfamily A member 10
chr4_-_99435396 0.18 ENST00000209665.8
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr10_+_49610297 0.17 ENST00000374115.5
SLC18A3
solute carrier family 18 member A3
chr7_+_130293134 0.10 ENST00000445470.6
ENST00000492072.5
ENST00000222482.10
ENST00000473956.5
ENST00000493259.5
ENST00000486598.1
CPA4
carboxypeptidase A4
chr11_-_68004043 0.10 ENST00000227471.7
UNC93B1
unc-93 homolog B1, TLR signaling regulator
chr2_+_225399684 0.09 ENST00000636099.1
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr14_+_21990357 0.04 ENST00000390444.1
TRAV16
T cell receptor alpha variable 16
chr12_-_52367478 0.03 ENST00000257901.7
KRT85
keratin 85

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
12.3 36.8 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
4.7 42.0 GO:0002175 protein localization to paranode region of axon(GO:0002175)
2.9 14.5 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
2.5 17.6 GO:0070560 protein secretion by platelet(GO:0070560)
2.5 7.4 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
2.3 88.3 GO:0008045 motor neuron axon guidance(GO:0008045)
2.2 22.3 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
2.1 32.1 GO:0007258 JUN phosphorylation(GO:0007258)
1.8 7.1 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
1.8 26.6 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
1.6 15.9 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) apical protein localization(GO:0045176)
1.4 52.0 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
1.3 18.6 GO:0048245 eosinophil chemotaxis(GO:0048245)
1.1 3.3 GO:0019557 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
1.0 14.7 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
1.0 9.1 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.8 32.5 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.8 35.3 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.8 4.6 GO:0071105 response to interleukin-11(GO:0071105)
0.7 2.9 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.7 4.2 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.7 7.2 GO:0021730 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.6 9.3 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.6 6.1 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.6 3.9 GO:0098908 regulation of neuronal action potential(GO:0098908)
0.5 1.6 GO:0046603 negative regulation of mitotic centrosome separation(GO:0046603)
0.5 4.2 GO:0048014 Tie signaling pathway(GO:0048014)
0.5 33.5 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.5 15.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.5 12.1 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.5 21.6 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.4 3.6 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.4 1.8 GO:0010193 response to ozone(GO:0010193)
0.4 2.7 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
0.4 9.4 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.4 70.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.4 4.6 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.4 10.6 GO:0015874 norepinephrine transport(GO:0015874)
0.3 3.4 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.3 1.0 GO:1990451 cellular stress response to acidic pH(GO:1990451)
0.3 2.7 GO:0061709 reticulophagy(GO:0061709)
0.3 29.8 GO:0006749 glutathione metabolic process(GO:0006749)
0.3 3.1 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.3 2.4 GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128)
0.3 1.7 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180)
0.3 7.2 GO:0043968 histone H2A acetylation(GO:0043968)
0.3 4.8 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.3 18.7 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.3 4.1 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.3 3.8 GO:0035878 nail development(GO:0035878)
0.2 2.8 GO:0045046 peroxisome fission(GO:0016559) protein import into peroxisome membrane(GO:0045046)
0.2 69.8 GO:0043401 steroid hormone mediated signaling pathway(GO:0043401)
0.2 19.3 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.2 1.0 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.2 7.1 GO:0060292 long term synaptic depression(GO:0060292)
0.2 0.8 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.2 3.2 GO:0090344 negative regulation of cell aging(GO:0090344)
0.2 2.2 GO:0042407 cristae formation(GO:0042407)
0.2 4.3 GO:0034505 tooth mineralization(GO:0034505)
0.2 1.3 GO:0015747 urate transport(GO:0015747)
0.2 3.4 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 1.1 GO:0045423 regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423) positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.2 3.7 GO:0030299 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.2 3.8 GO:0030488 tRNA methylation(GO:0030488)
0.2 15.3 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.2 3.0 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.2 16.7 GO:0006334 nucleosome assembly(GO:0006334)
0.1 5.5 GO:0005980 glycogen catabolic process(GO:0005980)
0.1 15.6 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.1 0.8 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.1 1.8 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.1 6.1 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 4.3 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.1 9.2 GO:0006446 regulation of translational initiation(GO:0006446)
0.1 13.4 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.1 12.1 GO:0035264 multicellular organism growth(GO:0035264)
0.1 0.5 GO:0051026 chiasma assembly(GO:0051026)
0.1 0.5 GO:0002158 osteoclast proliferation(GO:0002158)
0.1 1.2 GO:0035635 entry of bacterium into host cell(GO:0035635)
0.1 1.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 1.1 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.5 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.2 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.0 1.5 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.5 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 5.0 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.3 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.2 GO:0015870 acetylcholine transport(GO:0015870) acetate ester transport(GO:1901374)
0.0 0.2 GO:0034465 response to carbon monoxide(GO:0034465)
0.0 4.7 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 6.8 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)
0.0 0.5 GO:0002360 T cell lineage commitment(GO:0002360) homeostasis of number of cells within a tissue(GO:0048873)
0.0 0.1 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.0 1.6 GO:0072163 ureteric bud development(GO:0001657) mesonephric epithelium development(GO:0072163) mesonephric tubule development(GO:0072164)
0.0 0.6 GO:0050918 positive chemotaxis(GO:0050918)
0.0 1.7 GO:0048813 dendrite morphogenesis(GO:0048813)
0.0 3.6 GO:0007163 establishment or maintenance of cell polarity(GO:0007163)
0.0 0.8 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)
0.0 1.4 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.0 4.1 GO:0000226 microtubule cytoskeleton organization(GO:0000226)
0.0 0.4 GO:0048146 positive regulation of fibroblast proliferation(GO:0048146)
0.0 0.4 GO:0034067 protein localization to Golgi apparatus(GO:0034067)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
7.4 36.9 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
2.1 42.0 GO:0033270 paranode region of axon(GO:0033270)
1.7 6.8 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
1.4 35.3 GO:0044295 axonal growth cone(GO:0044295)
1.2 15.3 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
1.0 21.8 GO:0043194 axon initial segment(GO:0043194)
1.0 18.6 GO:0031045 dense core granule(GO:0031045)
1.0 2.9 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.8 21.2 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.8 4.2 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.5 5.5 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.4 7.1 GO:0005883 neurofilament(GO:0005883)
0.4 3.3 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.4 22.3 GO:0043034 costamere(GO:0043034)
0.4 2.2 GO:0061617 MICOS complex(GO:0061617)
0.3 7.2 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.3 1.9 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.2 9.3 GO:0030673 axolemma(GO:0030673)
0.2 22.6 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.2 14.5 GO:0043198 dendritic shaft(GO:0043198)
0.2 42.0 GO:0030018 Z disc(GO:0030018)
0.2 7.2 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 1.8 GO:0042788 polysomal ribosome(GO:0042788)
0.1 3.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.1 3.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 36.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 4.2 GO:0009925 basal plasma membrane(GO:0009925)
0.1 18.2 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.1 1.2 GO:0005915 zonula adherens(GO:0005915)
0.1 16.3 GO:0008021 synaptic vesicle(GO:0008021)
0.1 6.5 GO:0031526 brush border membrane(GO:0031526)
0.1 7.8 GO:0043197 dendritic spine(GO:0043197)
0.1 2.4 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.1 18.9 GO:0005802 trans-Golgi network(GO:0005802)
0.1 1.0 GO:0071438 invadopodium membrane(GO:0071438)
0.1 12.0 GO:0030496 midbody(GO:0030496)
0.1 12.2 GO:0032993 protein-DNA complex(GO:0032993)
0.0 3.1 GO:0016459 myosin complex(GO:0016459)
0.0 1.5 GO:0043235 receptor complex(GO:0043235)
0.0 0.8 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 1.6 GO:0005871 kinesin complex(GO:0005871)
0.0 1.4 GO:0016592 mediator complex(GO:0016592)
0.0 2.7 GO:0030426 growth cone(GO:0030426)
0.0 6.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 15.1 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.5 GO:0032300 mismatch repair complex(GO:0032300)
0.0 2.3 GO:0005884 actin filament(GO:0005884)
0.0 8.7 GO:0005667 transcription factor complex(GO:0005667)
0.0 84.9 GO:0016021 integral component of membrane(GO:0016021)
0.0 0.8 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.6 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 6.1 GO:0005925 focal adhesion(GO:0005925)
0.0 3.3 GO:0000790 nuclear chromatin(GO:0000790)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
9.2 36.8 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
7.4 36.8 GO:0030348 syntaxin-3 binding(GO:0030348)
2.7 10.6 GO:0005334 norepinephrine:sodium symporter activity(GO:0005334)
2.5 32.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
1.8 88.3 GO:0046875 ephrin receptor binding(GO:0046875)
1.6 14.5 GO:0035727 lysophosphatidic acid binding(GO:0035727)
1.5 7.4 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
1.4 15.2 GO:0032051 clathrin light chain binding(GO:0032051)
1.3 15.9 GO:0019911 structural constituent of myelin sheath(GO:0019911)
1.3 32.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
1.1 15.9 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
1.0 4.2 GO:0002046 opsin binding(GO:0002046)
1.0 3.1 GO:0004638 phosphoribosylaminoimidazole carboxylase activity(GO:0004638) phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
1.0 7.1 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.8 47.1 GO:0030507 spectrin binding(GO:0030507)
0.7 2.9 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.7 12.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.7 14.4 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.7 9.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.7 3.3 GO:0016841 ammonia-lyase activity(GO:0016841)
0.6 21.9 GO:0015248 sterol transporter activity(GO:0015248)
0.6 4.6 GO:0050693 LBD domain binding(GO:0050693)
0.5 5.5 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.5 26.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.5 4.3 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.5 9.1 GO:0031432 titin binding(GO:0031432)
0.5 8.0 GO:0042577 phosphatidate phosphatase activity(GO:0008195) lipid phosphatase activity(GO:0042577)
0.5 69.8 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.5 4.2 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.5 2.9 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.5 3.2 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.4 3.6 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.4 19.2 GO:0042056 chemoattractant activity(GO:0042056)
0.4 12.1 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.4 9.4 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.4 20.6 GO:0030552 cAMP binding(GO:0030552)
0.4 2.8 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.3 1.0 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.3 0.8 GO:0032093 SAM domain binding(GO:0032093)
0.3 3.8 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.3 35.3 GO:0005262 calcium channel activity(GO:0005262)
0.3 1.0 GO:0032184 SUMO polymer binding(GO:0032184)
0.3 7.8 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.2 37.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 2.5 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.2 4.0 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.2 37.4 GO:0044325 ion channel binding(GO:0044325)
0.2 0.8 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.2 15.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 15.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.2 6.8 GO:0030332 cyclin binding(GO:0030332)
0.2 3.8 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.1 3.1 GO:0016805 dipeptidase activity(GO:0016805)
0.1 1.6 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 82.9 GO:0005509 calcium ion binding(GO:0005509)
0.1 1.8 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.1 0.5 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.5 GO:0004977 melanocortin receptor activity(GO:0004977)
0.1 0.3 GO:0016524 latrotoxin receptor activity(GO:0016524)
0.1 1.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.7 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 4.2 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 0.2 GO:0004031 aldehyde oxidase activity(GO:0004031) ethanol binding(GO:0035276)
0.0 5.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.2 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375)
0.0 1.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.4 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 9.6 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 5.2 GO:0005516 calmodulin binding(GO:0005516)
0.0 3.1 GO:0003774 motor activity(GO:0003774)
0.0 0.5 GO:0005537 mannose binding(GO:0005537)
0.0 0.2 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 0.5 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 1.2 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.1 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 2.3 GO:0008017 microtubule binding(GO:0008017)
0.0 0.1 GO:0035325 Toll-like receptor binding(GO:0035325)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 88.3 PID RAC1 REG PATHWAY Regulation of RAC1 activity
1.1 70.6 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.4 26.6 PID FAS PATHWAY FAS (CD95) signaling pathway
0.3 15.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.3 24.9 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.2 9.1 PID AURORA A PATHWAY Aurora A signaling
0.2 14.5 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.1 4.2 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 7.8 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 9.9 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 14.4 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 1.8 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 1.2 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 4.2 PID SHP2 PATHWAY SHP2 signaling
0.1 3.8 PID LKB1 PATHWAY LKB1 signaling events
0.0 5.1 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.1 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 1.7 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 7.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.0 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 1.0 PID TGFBR PATHWAY TGF-beta receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 36.8 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
1.3 52.0 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
1.1 32.1 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.9 29.8 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.6 24.9 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.6 7.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.5 88.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.4 3.0 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.4 10.6 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.4 6.4 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.3 2.7 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.2 16.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.2 9.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 4.2 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.2 7.2 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.2 5.5 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.2 3.8 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.2 4.0 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 4.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 18.4 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 9.3 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 3.1 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 10.1 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 1.8 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 3.4 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 3.3 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.5 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 6.9 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 0.8 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.2 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 2.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.8 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.5 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.4 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.1 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction