Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for ISL2
Z-value: 0.67
Motif logo
Transcription factors associated with ISL2
Network of associatons between targets according to the STRING database.
First level regulatory network of ISL2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_+_34993240 Show fit | 20.35 |
ENST00000677647.1
|
signal recognition particle 54 |
|
| chr2_-_10447771 Show fit | 16.87 |
ENST00000405333.5
ENST00000443218.1 |
ornithine decarboxylase 1 |
|
| chr10_-_93482326 Show fit | 16.00 |
ENST00000359263.9
|
myoferlin |
|
| chr8_-_63026179 Show fit | 15.88 |
ENST00000677919.1
|
gamma-glutamyl hydrolase |
|
| chr10_-_93482194 Show fit | 15.62 |
ENST00000358334.9
ENST00000371488.3 |
myoferlin |
|
| chr4_+_112647059 Show fit | 12.41 |
ENST00000511529.1
|
La ribonucleoprotein 7, transcriptional regulator |
|
| chr7_+_16661182 Show fit | 11.29 |
ENST00000446596.5
ENST00000452975.6 ENST00000438834.5 |
basic leucine zipper and W2 domains 2 |
|
| chr11_-_107858777 Show fit | 11.23 |
ENST00000525815.6
|
solute carrier family 35 member F2 |
|
| chr3_-_142029108 Show fit | 10.35 |
ENST00000497579.5
|
transcription factor Dp-2 |
|
| chr13_+_30422487 Show fit | 10.14 |
ENST00000638137.1
ENST00000635918.2 |
ubiquitin conjugating enzyme E2 L5 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 31.6 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 5.1 | 20.4 | GO:0006617 | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617) |
| 3.4 | 16.9 | GO:0033387 | putrescine biosynthetic process from ornithine(GO:0033387) |
| 4.0 | 15.9 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
| 0.6 | 11.8 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.2 | 10.3 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 1.2 | 9.4 | GO:0071847 | TNFSF11-mediated signaling pathway(GO:0071847) |
| 3.1 | 9.2 | GO:0044878 | mitotic cytokinesis checkpoint(GO:0044878) |
| 0.1 | 8.9 | GO:1902653 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
| 0.0 | 8.1 | GO:0016050 | vesicle organization(GO:0016050) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 31.6 | GO:0005901 | caveola(GO:0005901) |
| 2.3 | 20.4 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 0.2 | 15.9 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 11.6 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.2 | 11.0 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 10.3 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 10.3 | GO:0043197 | dendritic spine(GO:0043197) |
| 1.0 | 9.2 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.4 | 8.9 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
| 0.0 | 8.1 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 29.5 | GO:0005543 | phospholipid binding(GO:0005543) |
| 3.4 | 20.4 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
| 0.3 | 16.9 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.7 | 15.9 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.0 | 12.6 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 0.5 | 11.8 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.0 | 11.3 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.2 | 9.4 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 1.0 | 9.2 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 3.0 | 8.9 | GO:0050613 | delta14-sterol reductase activity(GO:0050613) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 38.0 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.1 | 16.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 10.3 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 9.9 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.1 | 9.4 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 9.2 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 5.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 4.4 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 3.1 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 2.4 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.4 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.8 | 16.9 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.6 | 16.6 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 14.7 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.2 | 8.9 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.5 | 7.8 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.3 | 6.4 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.2 | 5.9 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.3 | 5.2 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.2 | 4.4 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |