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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for JUN
Z-value: 1.16
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Transcription factors associated with JUN
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| JUN | hg38_v1_chr1_-_58784035_58784054 | 0.05 | 4.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of JUN
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 81.7 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 1.4 | 44.4 | GO:0050427 | purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) |
| 0.2 | 29.7 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 1.5 | 25.7 | GO:0036149 | phosphatidylinositol acyl-chain remodeling(GO:0036149) |
| 1.7 | 25.5 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 2.1 | 25.2 | GO:0051581 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 1.4 | 24.4 | GO:0061339 | establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339) |
| 0.8 | 24.0 | GO:0010763 | positive regulation of fibroblast migration(GO:0010763) |
| 2.6 | 23.4 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
| 4.7 | 23.3 | GO:1904209 | regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 97.2 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.4 | 86.9 | GO:0030426 | growth cone(GO:0030426) |
| 0.3 | 57.6 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 46.8 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.1 | 40.6 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.4 | 33.5 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.3 | 32.5 | GO:0043204 | perikaryon(GO:0043204) |
| 0.5 | 26.2 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 1.3 | 23.4 | GO:0033270 | paranode region of axon(GO:0033270) |
| 3.9 | 23.3 | GO:0033269 | internode region of axon(GO:0033269) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 72.8 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.4 | 70.3 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.6 | 53.3 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 2.6 | 46.3 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.3 | 32.7 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.5 | 27.1 | GO:0030507 | spectrin binding(GO:0030507) |
| 1.8 | 25.8 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
| 3.2 | 25.7 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
| 0.7 | 25.6 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 1.8 | 25.5 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 44.8 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.6 | 27.4 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.7 | 17.5 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.5 | 16.5 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.3 | 15.1 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.2 | 14.7 | PID NFAT 3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| 0.3 | 14.1 | PID ATM PATHWAY | ATM pathway |
| 0.2 | 11.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.4 | 11.7 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.2 | 11.6 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 55.9 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 2.0 | 46.3 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.8 | 34.8 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 1.2 | 27.4 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.3 | 27.1 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 1.5 | 25.7 | REACTOME ACYL CHAIN REMODELLING OF PI | Genes involved in Acyl chain remodelling of PI |
| 0.2 | 20.4 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.4 | 20.3 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 1.0 | 18.3 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.7 | 17.6 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |