ISMARA results: JUND

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for JUND

Z-value: 0.87

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Transcription factors associated with JUND

Gene Symbol	Gene ID	Gene Info
JUND Ensembl NCBI GeneCards UniProt	ENSG00000130522.6	JUND

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
JUND	hg38_v1_chr19_-_18280806_18280929	0.51	3.7e-16	Click!

Activity profile of JUND motif

Sorted Z-values of JUND motif

Network of associatons between targets according to the STRING database.

First level regulatory network of JUND

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Promoter	Score	Transcript	Gene	Gene Info
chr3_-_18424533 Show fit	22.90	ENST00000417717.6	SATB1 Ensembl NCBI GeneCards UniProt Show fit	SATB homeobox 1
chr5_-_140633167 Show fit	20.02	ENST00000302014.11	CD14 Ensembl NCBI GeneCards UniProt Show fit	CD14 molecule
chr5_-_140633690 Show fit	18.30	ENST00000512545.1 ENST00000401743.6	CD14 Ensembl NCBI GeneCards UniProt Show fit	CD14 molecule
chr6_+_33075952 Show fit	17.97	ENST00000418931.7	HLA-DPB1 Ensembl NCBI GeneCards UniProt Show fit	major histocompatibility complex, class II, DP beta 1
chr4_-_83114715 Show fit	16.91	ENST00000426923.2 ENST00000311507.9 ENST00000509973.5	PLAC8 Ensembl NCBI GeneCards UniProt Show fit	placenta associated 8
chr3_-_18425295 Show fit	15.04	ENST00000338745.11 ENST00000450898.1	SATB1 Ensembl NCBI GeneCards UniProt Show fit	SATB homeobox 1
chr21_+_41370452 Show fit	14.56	ENST00000680862.1	MX2 Ensembl NCBI GeneCards UniProt Show fit	MX dynamin like GTPase 2
chr7_-_36985060 Show fit	11.96	ENST00000396040.6	ELMO1 Ensembl NCBI GeneCards UniProt Show fit	engulfment and cell motility 1
chr1_-_153375591 Show fit	11.69	ENST00000368737.5	S100A12 Ensembl NCBI GeneCards UniProt Show fit	S100 calcium binding protein A12
chr1_+_116754422 Show fit	10.02	ENST00000369478.4 ENST00000369477.1	CD2 Ensembl NCBI GeneCards UniProt Show fit	CD2 molecule

Showing 1 to 10 of 140 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.8	41.7	GO:0043374	CD8-positive, alpha-beta T cell differentiation(GO:0043374)
7.7	38.3	GO:0071727	toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
1.2	23.1	GO:0003374	dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
6.3	18.9	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
0.2	17.7	GO:0032729	positive regulation of interferon-gamma production(GO:0032729)
0.9	16.9	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
1.4	15.4	GO:0051344	negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.2	14.4	GO:0034113	heterotypic cell-cell adhesion(GO:0034113)
1.8	12.7	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.4	12.0	GO:0016601	Rac protein signal transduction(GO:0016601)

Showing 1 to 10 of 81 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.3	38.3	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.9	37.9	GO:0005720	nuclear heterochromatin(GO:0005720)
0.3	18.6	GO:0015030	Cajal body(GO:0015030)
0.9	18.0	GO:0042613	MHC class II protein complex(GO:0042613)
0.1	16.9	GO:0035578	azurophil granule lumen(GO:0035578)
2.6	15.4	GO:0034751	aryl hydrocarbon receptor complex(GO:0034751)
0.0	14.7	GO:0009897	external side of plasma membrane(GO:0009897)
0.3	14.4	GO:0008305	integrin complex(GO:0008305)
0.1	13.1	GO:0005643	nuclear pore(GO:0005643)
0.9	12.0	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)

Showing 1 to 10 of 47 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	40.6	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
9.6	38.3	GO:0016019	peptidoglycan receptor activity(GO:0016019)
0.1	25.3	GO:0003924	GTPase activity(GO:0003924)
6.3	18.9	GO:0008859	exoribonuclease II activity(GO:0008859)
0.5	18.0	GO:0042605	peptide antigen binding(GO:0042605)
0.0	15.9	GO:0060089	receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.4	15.6	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
1.0	15.4	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	13.0	GO:0001071	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.5	12.7	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)

Showing 1 to 10 of 65 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	38.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.2	27.3	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.3	14.4	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.2	12.7	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.2	12.0	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.1	8.6	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.3	7.7	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	7.3	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.2	6.4	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	6.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Showing 1 to 10 of 27 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	42.0	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
2.9	38.3	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.3	27.3	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.2	24.4	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall
0.9	18.0	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1	12.7	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.3	12.0	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1	11.9	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.5	11.7	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.1	9.3	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation

Showing 1 to 10 of 32 entries

Results for JUND

Z-value: 0.87

Motif logo

Transcription factors associated with JUND

Activity-expression correlation:

Activity profile of JUND motif

Sorted Z-values of JUND motif

Network of associatons between targets according to the STRING database.

First level regulatory network of JUND

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: