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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for KLF12
Z-value: 0.72
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Transcription factors associated with KLF12
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF12 | hg38_v1_chr13_-_74133892_74133941 | -0.02 | 7.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF12
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 16.1 | GO:0034389 | lipid particle organization(GO:0034389) |
| 2.1 | 14.9 | GO:0060770 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) cellular response to cobalt ion(GO:0071279) |
| 0.7 | 10.3 | GO:2000680 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 0.1 | 9.2 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 0.4 | 8.9 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 1.3 | 6.5 | GO:0034721 | histone H3-K4 demethylation, trimethyl-H3-K4-specific(GO:0034721) |
| 1.3 | 6.4 | GO:0072301 | regulation of metanephric glomerular mesangial cell proliferation(GO:0072301) |
| 1.0 | 6.3 | GO:0071105 | response to interleukin-11(GO:0071105) |
| 0.8 | 6.2 | GO:0045905 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.0 | 5.8 | GO:0007286 | spermatid development(GO:0007286) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.1 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 1.4 | 14.9 | GO:0043203 | axon hillock(GO:0043203) |
| 0.0 | 10.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.9 | 10.3 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.1 | 9.4 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.1 | 8.3 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.4 | 6.2 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.0 | 5.4 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 4.6 | GO:0005814 | centriole(GO:0005814) |
| 0.2 | 4.5 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 15.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 2.2 | 8.9 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 0.4 | 6.8 | GO:0050693 | LBD domain binding(GO:0050693) |
| 1.3 | 6.5 | GO:0034647 | histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647) |
| 0.0 | 6.5 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 1.3 | 6.4 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 0.3 | 6.2 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.6 | 5.6 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.4 | 5.4 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 6.8 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 5.6 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.1 | 4.6 | PID FOXO PATHWAY | FoxO family signaling |
| 0.1 | 4.1 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 3.7 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 3.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 2.0 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.9 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.9 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 6.6 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.3 | 5.6 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 4.6 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.3 | 3.4 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.2 | 3.1 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.0 | 2.7 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 2.2 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 2.1 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.1 | 2.0 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |