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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for KLF13
Z-value: 0.64
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Transcription factors associated with KLF13
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF13 | hg38_v1_chr15_+_31326807_31326892 | 0.28 | 2.8e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF13
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_+_30604028 Show fit | 8.74 |
ENST00000566740.2
|
golgin A8 family member H |
|
| chr19_+_1071194 Show fit | 6.37 |
ENST00000543365.5
|
Rho GTPase activating protein 45 |
|
| chr19_+_49363074 Show fit | 6.26 |
ENST00000597873.5
|
dickkopf like acrosomal protein 1 |
|
| chr1_+_153776596 Show fit | 5.94 |
ENST00000458027.5
|
solute carrier family 27 member 3 |
|
| chr19_+_49363730 Show fit | 5.85 |
ENST00000596402.1
ENST00000221498.7 |
dickkopf like acrosomal protein 1 |
|
| chr19_+_49363923 Show fit | 5.41 |
ENST00000597546.1
|
dickkopf like acrosomal protein 1 |
|
| chr7_+_100177743 Show fit | 5.18 |
ENST00000394018.6
ENST00000416412.5 |
stromal antigen 3 |
|
| chr7_+_100177897 Show fit | 4.94 |
ENST00000317296.9
ENST00000615138.5 ENST00000620100.5 ENST00000422690.5 ENST00000439782.1 |
stromal antigen 3 |
|
| chr6_+_89080739 Show fit | 4.93 |
ENST00000369472.1
ENST00000336032.4 |
proline rich nuclear receptor coactivator 1 |
|
| chr5_+_154858537 Show fit | 4.76 |
ENST00000517568.5
ENST00000524105.5 |
CCR4-NOT transcription complex subunit 8 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 18.3 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 2.0 | 12.2 | GO:0006050 | mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051) |
| 0.3 | 11.3 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.6 | 10.1 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
| 0.8 | 6.7 | GO:0002353 | kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353) |
| 0.0 | 6.0 | GO:0018108 | peptidyl-tyrosine phosphorylation(GO:0018108) |
| 0.0 | 5.9 | GO:0001676 | long-chain fatty acid metabolic process(GO:0001676) |
| 0.8 | 5.6 | GO:0045007 | depurination(GO:0045007) |
| 0.0 | 5.1 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 0.2 | 5.0 | GO:0032495 | response to muramyl dipeptide(GO:0032495) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.6 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 1.4 | 10.1 | GO:0030893 | meiotic cohesin complex(GO:0030893) |
| 0.8 | 9.9 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.0 | 6.6 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 1.0 | 4.9 | GO:0072558 | NLRP1 inflammasome complex(GO:0072558) |
| 0.4 | 4.7 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.4 | 4.0 | GO:0044194 | cytolytic granule(GO:0044194) |
| 0.0 | 3.4 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.3 | 3.3 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.0 | 3.3 | GO:0005814 | centriole(GO:0005814) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 12.2 | GO:0045127 | N-acetylglucosamine kinase activity(GO:0045127) |
| 0.6 | 11.3 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.3 | 6.7 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.1 | 6.0 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.3 | 5.9 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.0 | 5.8 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 1.4 | 5.6 | GO:0032408 | MutLbeta complex binding(GO:0032406) MutSbeta complex binding(GO:0032408) |
| 0.7 | 4.9 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.2 | 4.9 | GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656) |
| 0.0 | 4.7 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.8 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 4.9 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 4.9 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.1 | 3.2 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 2.9 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.1 | 2.7 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.1 | 2.5 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 2.4 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 2.2 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 2.0 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.7 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.3 | 9.9 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.3 | 6.7 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.2 | 6.0 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.3 | 5.6 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.2 | 4.9 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.2 | 3.4 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 3.0 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.1 | 2.7 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 2.6 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |