Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for KLF15
Z-value: 0.81
Motif logo
Transcription factors associated with KLF15
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF15 | hg38_v1_chr3_-_126357399_126357414 | 0.02 | 8.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF15
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_17217617 Show fit | 16.20 |
ENST00000322611.4
|
brain abundant membrane attached signal protein 1 |
|
| chr9_+_17579059 Show fit | 7.26 |
ENST00000380607.5
|
SH3 domain containing GRB2 like 2, endophilin A1 |
|
| chr1_-_31764333 Show fit | 5.89 |
ENST00000398542.5
ENST00000373658.8 |
adhesion G protein-coupled receptor B2 |
|
| chr11_-_119423162 Show fit | 5.60 |
ENST00000284240.10
ENST00000524970.5 |
Thy-1 cell surface antigen |
|
| chr15_-_45187955 Show fit | 5.07 |
ENST00000560471.5
ENST00000560540.5 |
Src homology 2 domain containing F |
|
| chr2_+_219627650 Show fit | 4.86 |
ENST00000317151.7
|
solute carrier family 4 member 3 |
|
| chr16_+_56191476 Show fit | 4.83 |
ENST00000262493.12
|
G protein subunit alpha o1 |
|
| chr2_+_219627565 Show fit | 4.75 |
ENST00000273063.10
|
solute carrier family 4 member 3 |
|
| chr11_-_31817937 Show fit | 4.50 |
ENST00000638965.1
ENST00000241001.13 ENST00000638914.3 ENST00000379132.8 ENST00000379129.7 |
paired box 6 |
|
| chr11_-_31817904 Show fit | 4.50 |
ENST00000423822.7
|
paired box 6 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 16.2 | GO:2001076 | regulation of metanephric ureteric bud development(GO:2001074) positive regulation of metanephric ureteric bud development(GO:2001076) |
| 0.2 | 13.3 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.8 | 13.2 | GO:0003322 | pancreatic A cell development(GO:0003322) |
| 1.2 | 11.1 | GO:0060125 | negative regulation of growth hormone secretion(GO:0060125) |
| 0.0 | 10.7 | GO:0006457 | protein folding(GO:0006457) |
| 0.1 | 9.7 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.4 | 8.4 | GO:1904778 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.5 | 8.3 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 2.6 | 7.8 | GO:1904692 | positive regulation of type B pancreatic cell proliferation(GO:1904692) |
| 0.5 | 7.8 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 23.7 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.3 | 19.4 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 15.6 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 13.0 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.2 | 10.3 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.1 | 8.9 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.1 | 8.1 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.0 | 7.6 | GO:0005929 | cilium(GO:0005929) |
| 0.0 | 7.5 | GO:0005694 | chromosome(GO:0005694) |
| 0.0 | 6.3 | GO:0015630 | microtubule cytoskeleton(GO:0015630) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.3 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.2 | 17.2 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.8 | 16.2 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.9 | 11.4 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.3 | 10.2 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.2 | 9.6 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 9.1 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 8.2 | GO:0005518 | collagen binding(GO:0005518) |
| 0.5 | 8.0 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.1 | 7.2 | GO:0019894 | kinesin binding(GO:0019894) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.2 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.2 | 12.2 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.1 | 12.0 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.4 | 10.2 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 8.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 5.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 5.2 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.1 | 3.4 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.0 | 3.2 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 3.1 | PID REELIN PATHWAY | Reelin signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.9 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 16.0 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.2 | 13.5 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.4 | 13.2 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.2 | 9.8 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.6 | 7.5 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.3 | 7.3 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.2 | 5.9 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.1 | 5.3 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 4.3 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |