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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for KLF16_SP2
Z-value: 1.69
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Transcription factors associated with KLF16_SP2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP2 | hg38_v1_chr17_+_47896150_47896262 | 0.28 | 2.6e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF16_SP2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 248.7 | GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) |
| 3.2 | 237.7 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 8.5 | 187.1 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 2.1 | 160.9 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 1.1 | 158.9 | GO:0006364 | rRNA processing(GO:0006364) |
| 0.6 | 119.8 | GO:0000375 | RNA splicing, via transesterification reactions(GO:0000375) |
| 1.6 | 118.3 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 10.6 | 117.1 | GO:0085020 | protein K6-linked ubiquitination(GO:0085020) |
| 2.8 | 116.7 | GO:0000291 | nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) |
| 2.3 | 115.3 | GO:0050434 | positive regulation of viral transcription(GO:0050434) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 611.4 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.8 | 246.7 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 1.8 | 180.1 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 1.6 | 157.2 | GO:0000776 | kinetochore(GO:0000776) |
| 1.5 | 154.6 | GO:0031970 | mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970) |
| 1.4 | 136.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 3.2 | 124.5 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 4.0 | 111.3 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 1.9 | 111.1 | GO:0005876 | spindle microtubule(GO:0005876) |
| 1.9 | 105.9 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 521.6 | GO:0003723 | RNA binding(GO:0003723) |
| 1.7 | 339.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.5 | 232.9 | GO:0042393 | histone binding(GO:0042393) |
| 4.0 | 190.0 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 3.8 | 146.6 | GO:0008143 | poly(A) binding(GO:0008143) |
| 2.7 | 121.0 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 1.1 | 111.7 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 1.7 | 102.5 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 20.2 | 101.2 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 4.1 | 99.5 | GO:0070628 | proteasome binding(GO:0070628) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 265.5 | PID E2F PATHWAY | E2F transcription factor network |
| 2.1 | 237.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 4.5 | 228.3 | PID BARD1 PATHWAY | BARD1 signaling events |
| 2.2 | 143.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 2.4 | 117.9 | PID AURORA B PATHWAY | Aurora B signaling |
| 2.8 | 98.4 | PID ATM PATHWAY | ATM pathway |
| 2.5 | 88.3 | PID ATR PATHWAY | ATR signaling pathway |
| 2.1 | 82.8 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 1.2 | 80.0 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 1.2 | 76.5 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 277.3 | REACTOME M G1 TRANSITION | Genes involved in M/G1 Transition |
| 2.3 | 252.6 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 4.6 | 164.5 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 5.5 | 163.9 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 4.0 | 161.6 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 1.6 | 159.2 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 2.9 | 157.8 | REACTOME MITOTIC G1 G1 S PHASES | Genes involved in Mitotic G1-G1/S phases |
| 4.5 | 157.3 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 2.6 | 156.3 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 4.5 | 147.6 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |