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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for KLF3
Z-value: 1.05
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Transcription factors associated with KLF3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF3 | hg38_v1_chr4_+_38664189_38664206 | 0.37 | 2.8e-08 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_42825884 Show fit | 17.89 |
ENST00000506577.5
|
selenoprotein P |
|
| chr19_+_16197900 Show fit | 15.83 |
ENST00000429941.6
ENST00000291439.8 ENST00000444449.6 ENST00000589822.5 |
adaptor related protein complex 1 subunit mu 1 |
|
| chr1_+_2073462 Show fit | 14.42 |
ENST00000400921.6
|
protein kinase C zeta |
|
| chr16_+_66880503 Show fit | 12.76 |
ENST00000568869.1
ENST00000311765.4 ENST00000561704.1 ENST00000568398.1 ENST00000566776.1 |
pyruvate dehyrogenase phosphatase catalytic subunit 2 |
|
| chr14_-_21023318 Show fit | 12.09 |
ENST00000298684.9
ENST00000557169.5 ENST00000553563.5 |
NDRG family member 2 |
|
| chr1_-_182391323 Show fit | 11.68 |
ENST00000642379.1
|
glutamate-ammonia ligase |
|
| chr14_-_21023954 Show fit | 11.42 |
ENST00000554094.5
|
NDRG family member 2 |
|
| chr14_-_21024092 Show fit | 11.23 |
ENST00000554398.5
|
NDRG family member 2 |
|
| chr3_+_49412203 Show fit | 10.17 |
ENST00000273590.3
|
T cell leukemia translocation altered |
|
| chr14_-_21023144 Show fit | 10.08 |
ENST00000554531.5
|
NDRG family member 2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 44.8 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 2.1 | 27.4 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 4.8 | 23.9 | GO:2001181 | positive regulation of interleukin-10 secretion(GO:2001181) |
| 3.5 | 20.7 | GO:0071105 | response to interleukin-11(GO:0071105) |
| 1.2 | 18.0 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 2.2 | 17.9 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 0.8 | 15.8 | GO:0048757 | endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757) |
| 2.5 | 15.2 | GO:0010732 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 0.2 | 14.7 | GO:0006893 | Golgi to plasma membrane transport(GO:0006893) |
| 0.0 | 13.3 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 42.4 | GO:0030426 | growth cone(GO:0030426) |
| 3.0 | 23.9 | GO:0045179 | apical cortex(GO:0045179) |
| 1.1 | 20.2 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.9 | 18.5 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.2 | 15.2 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 1.6 | 14.7 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.4 | 11.7 | GO:0097386 | glial cell projection(GO:0097386) |
| 0.1 | 11.3 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.1 | 11.0 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 9.7 | GO:0016324 | apical plasma membrane(GO:0016324) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 23.9 | GO:0043560 | insulin receptor substrate binding(GO:0043560) |
| 0.1 | 21.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.3 | 20.7 | GO:0050693 | LBD domain binding(GO:0050693) |
| 1.6 | 19.0 | GO:0008430 | selenium binding(GO:0008430) |
| 1.4 | 18.0 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.3 | 16.7 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 15.7 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.7 | 15.6 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.5 | 14.6 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 14.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 48.4 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.7 | 44.4 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.1 | 19.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 18.9 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 18.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 16.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.2 | 11.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.3 | 10.6 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.1 | 9.7 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 7.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 19.3 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.7 | 18.4 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 1.1 | 15.8 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 15.2 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.8 | 15.0 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.8 | 12.8 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.2 | 12.6 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.4 | 11.7 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 11.4 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.4 | 11.1 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |