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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for KLF6
Z-value: 1.35
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Transcription factors associated with KLF6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF6 | hg38_v1_chr10_-_3785179_3785194 | 0.39 | 3.9e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 17.9 | 71.5 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
| 3.5 | 66.0 | GO:1901897 | regulation of relaxation of cardiac muscle(GO:1901897) |
| 0.5 | 46.7 | GO:0043966 | histone H3 acetylation(GO:0043966) |
| 0.4 | 37.9 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 9.8 | 29.5 | GO:0001869 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 6.7 | 26.8 | GO:0019074 | viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074) |
| 0.8 | 26.1 | GO:0045187 | regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
| 3.0 | 23.7 | GO:0046604 | positive regulation of mitotic centrosome separation(GO:0046604) |
| 2.3 | 23.0 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 3.8 | 22.9 | GO:0051138 | positive regulation of NK T cell differentiation(GO:0051138) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 95.7 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 3.0 | 84.4 | GO:0097386 | glial cell projection(GO:0097386) |
| 0.1 | 55.9 | GO:0043025 | neuronal cell body(GO:0043025) |
| 4.7 | 51.6 | GO:0070776 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
| 0.2 | 49.6 | GO:0098793 | presynapse(GO:0098793) |
| 0.2 | 37.5 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 25.3 | GO:0005813 | centrosome(GO:0005813) |
| 1.6 | 22.8 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.2 | 21.5 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.4 | 19.9 | GO:0048786 | presynaptic active zone(GO:0048786) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 17.9 | 71.5 | GO:0004356 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 4.3 | 55.8 | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) |
| 0.1 | 42.4 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.5 | 40.9 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 1.9 | 39.2 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.5 | 37.8 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.1 | 31.5 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.6 | 24.2 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.4 | 23.5 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 4.6 | 23.2 | GO:0042903 | tubulin deacetylase activity(GO:0042903) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 89.0 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 1.0 | 45.8 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.4 | 35.6 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.3 | 28.6 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.5 | 25.9 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.4 | 24.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.7 | 24.4 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.6 | 24.2 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 3.6 | 21.6 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.7 | 21.6 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 71.5 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.9 | 39.6 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 1.2 | 29.5 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.6 | 29.4 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.6 | 26.4 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.8 | 25.2 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.2 | 22.9 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 1.0 | 20.0 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.1 | 19.4 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.3 | 19.2 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |