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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for KLF7
Z-value: 0.40
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Transcription factors associated with KLF7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF7 | hg38_v1_chr2_-_207165923_207165965, hg38_v1_chr2_-_207167220_207167267 | 0.39 | 1.6e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF7
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 27.1 | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) |
| 3.5 | 10.6 | GO:2000777 | positive regulation of oocyte maturation(GO:1900195) negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777) |
| 0.7 | 8.0 | GO:0097012 | cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012) |
| 0.1 | 5.7 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.1 | 5.3 | GO:0045773 | positive regulation of axon extension(GO:0045773) |
| 0.0 | 4.9 | GO:0006661 | phosphatidylinositol biosynthetic process(GO:0006661) |
| 0.6 | 4.1 | GO:1901098 | positive regulation of autophagosome maturation(GO:1901098) |
| 1.1 | 3.3 | GO:0010133 | proline catabolic process to glutamate(GO:0010133) |
| 0.2 | 2.4 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.2 | 2.3 | GO:0006265 | DNA topological change(GO:0006265) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 10.6 | GO:0072687 | meiotic spindle(GO:0072687) |
| 2.7 | 8.0 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 0.7 | 4.1 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.0 | 3.5 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 2.5 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.3 | 2.2 | GO:1990745 | EARP complex(GO:1990745) |
| 0.1 | 2.0 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 1.4 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 1.2 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 0.7 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.2 | 24.8 | GO:0005163 | nerve growth factor receptor binding(GO:0005163) |
| 3.5 | 10.6 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) |
| 0.5 | 8.0 | GO:0017151 | DEAD/H-box RNA helicase binding(GO:0017151) |
| 0.3 | 5.8 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.1 | 4.1 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.1 | 3.3 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.0 | 2.4 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.8 | 2.3 | GO:0003917 | DNA topoisomerase type I activity(GO:0003917) |
| 0.0 | 2.2 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.3 | 2.0 | GO:0008158 | hedgehog receptor activity(GO:0008158) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 5.2 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 2.4 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 2.3 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 1.3 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 1.1 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.8 | ST GAQ PATHWAY | G alpha q Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 2.4 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 2.3 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.0 | 1.5 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 1.3 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.0 | 1.2 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 1.1 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.0 | 0.8 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.0 | 0.7 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.6 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |