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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for LEF1
Z-value: 0.90
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Transcription factors associated with LEF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| LEF1 | hg38_v1_chr4_-_108168919_108168939 | -0.07 | 2.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of LEF1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_+_30427950 Show fit | 19.80 |
ENST00000436446.1
|
ubiquitin conjugating enzyme E2 L5 |
|
| chr10_+_52314272 Show fit | 14.49 |
ENST00000373970.4
|
dickkopf WNT signaling pathway inhibitor 1 |
|
| chr5_+_138179145 Show fit | 14.10 |
ENST00000508792.5
ENST00000504621.1 |
kinesin family member 20A |
|
| chr14_+_54397021 Show fit | 14.05 |
ENST00000541304.5
|
cyclin dependent kinase inhibitor 3 |
|
| chr2_+_180981108 Show fit | 13.54 |
ENST00000602710.5
|
ubiquitin conjugating enzyme E2 E3 |
|
| chr14_+_54396949 Show fit | 13.27 |
ENST00000611205.4
|
cyclin dependent kinase inhibitor 3 |
|
| chr14_+_54396964 Show fit | 13.21 |
ENST00000543789.6
ENST00000442975.6 ENST00000458126.6 ENST00000556102.6 ENST00000335183.11 |
cyclin dependent kinase inhibitor 3 |
|
| chr5_+_138179093 Show fit | 13.19 |
ENST00000394894.8
|
kinesin family member 20A |
|
| chrX_-_136880715 Show fit | 12.89 |
ENST00000431446.7
ENST00000320676.11 ENST00000562646.5 |
RNA binding motif protein X-linked |
|
| chr3_-_142028597 Show fit | 12.45 |
ENST00000467667.5
|
transcription factor Dp-2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 48.0 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 1.6 | 27.3 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 0.7 | 26.5 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 2.7 | 24.5 | GO:0007070 | negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070) |
| 0.6 | 22.8 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 5.2 | 20.9 | GO:0032599 | B cell receptor transport within lipid bilayer(GO:0032595) B cell receptor transport into membrane raft(GO:0032597) protein transport out of membrane raft(GO:0032599) chemokine receptor transport out of membrane raft(GO:0032600) negative regulation of transforming growth factor beta3 production(GO:0032913) chemokine receptor transport within lipid bilayer(GO:0033606) |
| 0.4 | 17.2 | GO:0070534 | protein K63-linked ubiquitination(GO:0070534) |
| 4.0 | 16.0 | GO:0002188 | translation reinitiation(GO:0002188) |
| 3.8 | 15.3 | GO:1902544 | regulation of DNA N-glycosylase activity(GO:1902544) |
| 4.9 | 14.6 | GO:0009996 | negative regulation of cell fate specification(GO:0009996) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 33.2 | GO:0016514 | SWI/SNF complex(GO:0016514) npBAF complex(GO:0071564) |
| 0.1 | 32.1 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.2 | 24.9 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.9 | 20.9 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.4 | 19.7 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.3 | 19.0 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.7 | 17.2 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.1 | 16.0 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.1 | 15.9 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.3 | 15.4 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 41.3 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.1 | 38.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 35.1 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 0.3 | 26.3 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.4 | 25.8 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 1.3 | 24.5 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.5 | 23.9 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.6 | 21.3 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 1.0 | 21.1 | GO:0070878 | primary miRNA binding(GO:0070878) |
| 0.4 | 17.2 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 37.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.3 | 28.7 | PID E2F PATHWAY | E2F transcription factor network |
| 0.3 | 28.0 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.9 | 24.5 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.4 | 23.1 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.2 | 19.6 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 17.6 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.3 | 16.0 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.3 | 13.6 | PID MYC PATHWAY | C-MYC pathway |
| 0.3 | 13.5 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 42.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.9 | 26.4 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.5 | 23.9 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 22.0 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.2 | 19.7 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.7 | 18.6 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.5 | 15.7 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.4 | 15.4 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.8 | 15.3 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.5 | 13.8 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |