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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for LHX2

Z-value: 0.51

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Transcription factors associated with LHX2

Gene Symbol Gene ID Gene Info
LHX2
ENSG00000106689.11 LHX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX2hg38_v1_chr9_+_124015397_124015421,
hg38_v1_chr9_+_124011738_124011777		0.492.3e-14Click!

Activity profile of LHX2 motif

Sorted Z-values of LHX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_-_174847765 11.30 ENST00000443238.6
CHN1
chimerin 1
chr7_-_137343752 9.34 ENST00000393083.2
PTN
pleiotrophin
chr7_-_137343688 8.89 ENST00000348225.7
PTN
pleiotrophin
chr2_-_174847525 8.55 ENST00000295497.12
ENST00000652036.1
ENST00000444394.6
ENST00000650731.1
CHN1
chimerin 1
chr2_-_222656067 6.21 ENST00000281828.8
FARSB
phenylalanyl-tRNA synthetase subunit beta
chr5_+_36606355 6.20 ENST00000681909.1
ENST00000513903.5
ENST00000681795.1
ENST00000680125.1
ENST00000612708.5
ENST00000680232.1
ENST00000681776.1
ENST00000681926.1
ENST00000679958.1
ENST00000265113.9
ENST00000504121.5
ENST00000512374.1
ENST00000613445.5
ENST00000679983.1
SLC1A3
solute carrier family 1 member 3
chr12_-_91179472 5.94 ENST00000550099.5
ENST00000546391.5
DCN
decorin
chr3_+_35680994 5.50 ENST00000441454.5
ARPP21
cAMP regulated phosphoprotein 21
chr1_+_92168915 4.94 ENST00000637221.2
BTBD8
BTB domain containing 8
chr12_-_91179517 4.55 ENST00000551354.1
DCN
decorin
chr3_+_98147479 4.43 ENST00000641380.1
OR5H14
olfactory receptor family 5 subfamily H member 14
chr15_+_80441229 4.29 ENST00000533983.5
ENST00000527771.5
ENST00000525103.1
ARNT2
aryl hydrocarbon receptor nuclear translocator 2
chr14_+_69398683 4.17 ENST00000556605.5
ENST00000031146.8
ENST00000336643.10
SLC39A9
solute carrier family 39 member 9
chr10_+_93566659 4.17 ENST00000371481.9
ENST00000371483.8
ENST00000604414.1
FFAR4
free fatty acid receptor 4
chr17_+_46923075 3.50 ENST00000640608.1
ENST00000638634.1
ENST00000623037.2
ENST00000225567.9
ENST00000415811.7
ENST00000576910.7
ENST00000573224.2
ENST00000640621.1
ENST00000638892.1
ENST00000638838.1
ENST00000638216.1
ENST00000575949.6
ENST00000640806.1
ENST00000640269.1
ENST00000640443.1
ENST00000638697.1
ENST00000640051.2
ENST00000640007.1
ENST00000640711.1
ENST00000640495.1
ENST00000638374.1
ENST00000571048.1
ENST00000639287.1
ENST00000640138.1
ENST00000570879.2
ENST00000640068.1
ENST00000393456.7
ENST00000639031.1
GOSR2
golgi SNAP receptor complex member 2
chr10_-_88952763 3.25 ENST00000224784.10
ACTA2
actin alpha 2, smooth muscle
chr5_-_134367070 3.17 ENST00000521118.5
CDKL3
cyclin dependent kinase like 3
chr14_-_89412025 3.14 ENST00000553840.5
ENST00000556916.5
FOXN3
forkhead box N3
chr7_-_83649097 3.11 ENST00000643230.2
SEMA3E
semaphorin 3E
chr1_-_147670235 3.01 ENST00000392988.6
ACP6
acid phosphatase 6, lysophosphatidic
chr1_-_152360004 2.98 ENST00000388718.5
FLG2
filaggrin family member 2
chr10_-_97687191 2.91 ENST00000370626.4
AVPI1
arginine vasopressin induced 1
chr7_+_156640879 2.89 ENST00000311822.12
RNF32
ring finger protein 32
chr6_+_125203639 2.79 ENST00000392482.6
TPD52L1
TPD52 like 1
chr1_-_68050615 2.72 ENST00000646789.1
DIRAS3
DIRAS family GTPase 3
chr11_+_94973640 2.68 ENST00000335080.6
ENST00000536741.1
KDM4D
lysine demethylase 4D
chr13_+_24270681 2.62 ENST00000343003.10
ENST00000399949.6
SPATA13
spermatogenesis associated 13
chr13_-_19181773 2.60 ENST00000618094.1
ENST00000400113.8
TUBA3C
tubulin alpha 3c
chrM_+_12329 2.58 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5
chr7_-_14841267 2.57 ENST00000406247.7
ENST00000399322.7
DGKB
diacylglycerol kinase beta
chr2_+_68734861 2.50 ENST00000467265.5
ARHGAP25
Rho GTPase activating protein 25
chr2_+_102418642 2.40 ENST00000264260.6
IL18RAP
interleukin 18 receptor accessory protein
chr3_-_161105224 2.31 ENST00000651254.1
ENST00000651178.1
ENST00000476999.6
ENST00000652596.1
ENST00000651305.1
ENST00000652111.1
ENST00000651292.1
ENST00000651282.1
ENST00000651380.1
ENST00000494173.7
ENST00000484127.5
ENST00000650733.1
ENST00000494818.6
ENST00000492353.5
ENST00000652143.1
ENST00000473142.5
ENST00000651147.1
ENST00000468268.5
ENST00000460353.2
ENST00000651953.1
ENST00000651972.1
ENST00000652730.1
ENST00000651460.1
ENST00000652059.1
ENST00000651509.1
ENST00000651801.1
ENST00000651686.1
ENST00000320474.10
ENST00000392781.7
ENST00000392779.6
ENST00000651791.1
ENST00000651117.1
ENST00000652032.1
B3GALNT1
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chr12_-_118359105 2.30 ENST00000541186.5
ENST00000539872.5
TAOK3
TAO kinase 3
chr2_+_172821575 2.28 ENST00000397087.7
RAPGEF4
Rap guanine nucleotide exchange factor 4
chr11_+_36594369 2.26 ENST00000678060.1
ENST00000446510.6
ENST00000676979.1
ENST00000677808.1
ENST00000617650.5
ENST00000334307.10
ENST00000531554.6
ENST00000679022.1
ENST00000347206.8
ENST00000534635.5
ENST00000676921.1
ENST00000678950.1
ENST00000530697.6
ENST00000527108.6
ENST00000532470.3
IFTAP
intraflagellar transport associated protein
chr3_-_161105399 2.23 ENST00000652593.1
B3GALNT1
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chr1_+_160739286 2.19 ENST00000359331.8
ENST00000495334.1
SLAMF7
SLAM family member 7
chr1_+_160739265 2.15 ENST00000368042.7
SLAMF7
SLAM family member 7
chr5_-_134367144 2.11 ENST00000265334.9
CDKL3
cyclin dependent kinase like 3
chr3_-_161105070 1.98 ENST00000651430.1
ENST00000650695.1
ENST00000651689.1
ENST00000651916.1
ENST00000488170.5
ENST00000652377.1
ENST00000652669.1
B3GALNT1
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chr1_+_160739239 1.91 ENST00000368043.8
SLAMF7
SLAM family member 7
chr10_-_60141004 1.86 ENST00000355288.6
ANK3
ankyrin 3
chr2_-_74392025 1.86 ENST00000440727.1
ENST00000409240.5
DCTN1
dynactin subunit 1
chr9_+_102995308 1.83 ENST00000612124.4
ENST00000374798.8
ENST00000487798.5
CYLC2
cylicin 2
chr11_+_27055215 1.74 ENST00000525090.1
BBOX1
gamma-butyrobetaine hydroxylase 1
chr18_+_31447732 1.73 ENST00000257189.5
DSG3
desmoglein 3
chr9_-_21202205 1.68 ENST00000239347.3
IFNA7
interferon alpha 7
chr18_+_34976928 1.67 ENST00000591734.5
ENST00000413393.5
ENST00000589180.5
ENST00000587359.5
MAPRE2
microtubule associated protein RP/EB family member 2
chr2_-_208124514 1.62 ENST00000264376.5
CRYGD
crystallin gamma D
chr11_+_24496988 1.53 ENST00000336930.11
LUZP2
leucine zipper protein 2
chr6_+_26087281 1.47 ENST00000353147.9
ENST00000397022.7
ENST00000352392.8
ENST00000349999.8
ENST00000317896.11
ENST00000470149.5
ENST00000336625.12
ENST00000461397.5
ENST00000488199.5
HFE
homeostatic iron regulator
chrX_+_48255390 1.47 ENST00000376919.4
SSX1
SSX family member 1
chr1_-_7940825 1.45 ENST00000377507.8
TNFRSF9
TNF receptor superfamily member 9
chr18_+_36544544 1.43 ENST00000591635.5
FHOD3
formin homology 2 domain containing 3
chr5_-_24644968 1.42 ENST00000264463.8
CDH10
cadherin 10
chr3_-_12545499 1.40 ENST00000564146.4
MKRN2OS
MKRN2 opposite strand
chr11_-_4608226 1.34 ENST00000300747.10
ENST00000526337.5
TRIM68
tripartite motif containing 68
chr9_+_105558112 1.32 ENST00000223528.6
ENST00000675668.1
ENST00000357998.10
ENST00000448551.6
FKTN
fukutin
chr2_+_233307806 1.32 ENST00000447536.5
ENST00000409110.6
SAG
S-antigen visual arrestin
chr11_-_108222594 1.28 ENST00000278612.9
NPAT
nuclear protein, coactivator of histone transcription
chr10_-_114526897 1.28 ENST00000428430.1
ENST00000392952.7
ABLIM1
actin binding LIM protein 1
chr17_-_31314066 1.25 ENST00000577894.1
EVI2B
ecotropic viral integration site 2B
chr8_-_19602484 1.25 ENST00000454498.6
ENST00000520003.5
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr2_-_55049184 1.22 ENST00000357376.7
RTN4
reticulon 4
chr6_-_26199272 1.20 ENST00000650491.1
ENST00000635200.1
ENST00000341023.2
ENSG00000282988.2
H2AC7
novel protein
H2A clustered histone 7
chr3_+_4680617 1.15 ENST00000648212.1
ITPR1
inositol 1,4,5-trisphosphate receptor type 1
chr13_+_31945826 1.15 ENST00000647500.1
FRY
FRY microtubule binding protein
chr2_-_177618705 1.14 ENST00000355689.6
TTC30A
tetratricopeptide repeat domain 30A
chr10_-_104232301 1.12 ENST00000369720.6
ENST00000369719.2
ENST00000278064.7
ENST00000357060.8
CFAP43
cilia and flagella associated protein 43
chr14_+_22226711 1.09 ENST00000390463.3
TRAV36DV7
T cell receptor alpha variable 36/delta variable 7
chr3_+_73061659 1.09 ENST00000533473.1
EBLN2
endogenous Bornavirus like nucleoprotein 2
chr14_-_33951052 1.06 ENST00000250457.9
ENST00000547327.2
EGLN3
egl-9 family hypoxia inducible factor 3
chr20_+_44401397 1.05 ENST00000682427.1
ENST00000681977.1
ENST00000684136.1
ENST00000684046.1
ENST00000684476.1
ENST00000619550.5
ENST00000682169.1
HNF4A
hepatocyte nuclear factor 4 alpha
chr4_+_70360751 1.05 ENST00000226460.5
SMR3A
submaxillary gland androgen regulated protein 3A
chr12_-_25195074 1.03 ENST00000354189.9
ENST00000676236.1
ENST00000545133.5
ENST00000554347.1
ENST00000674567.1
ENST00000395987.8
ENST00000320267.13
ENST00000395990.6
CFAP94
cilia and flagella associated protein 94
chr5_+_141412979 1.00 ENST00000612503.1
ENST00000398610.3
PCDHGA10
protocadherin gamma subfamily A, 10
chr16_+_23641452 0.98 ENST00000300087.7
ENST00000563998.5
DCTN5
dynactin subunit 5
chr6_+_30880780 0.98 ENST00000460944.6
ENST00000324771.12
DDR1
discoidin domain receptor tyrosine kinase 1
chr7_-_5959083 0.98 ENST00000539903.5
RSPH10B
radial spoke head 10 homolog B
chr21_-_33641721 0.94 ENST00000399442.1
ENST00000413017.2
ENST00000445393.5
ENST00000417979.5
ENST00000381554.8
ENST00000426935.5
ENST00000381540.7
ENST00000361534.6
CRYZL1
crystallin zeta like 1
chr13_-_109786567 0.94 ENST00000375856.5
IRS2
insulin receptor substrate 2
chr3_+_108822778 0.92 ENST00000295756.11
TRAT1
T cell receptor associated transmembrane adaptor 1
chr3_+_108822759 0.87 ENST00000426646.1
TRAT1
T cell receptor associated transmembrane adaptor 1
chr7_-_22194709 0.84 ENST00000458533.5
RAPGEF5
Rap guanine nucleotide exchange factor 5
chr12_-_21775581 0.80 ENST00000537950.1
ENST00000665145.1
KCNJ8
potassium inwardly rectifying channel subfamily J member 8
chr6_+_112087576 0.77 ENST00000368656.7
ENST00000604268.1
FAM229B
family with sequence similarity 229 member B
chr6_-_130970428 0.76 ENST00000529208.5
EPB41L2
erythrocyte membrane protein band 4.1 like 2
chr12_+_93677352 0.76 ENST00000552983.5
ENST00000332896.8
ENST00000552033.5
ENST00000548483.5
CRADD
CASP2 and RIPK1 domain containing adaptor with death domain
chr2_+_161624335 0.76 ENST00000375514.9
ENST00000415876.6
SLC4A10
solute carrier family 4 member 10
chr11_+_63838902 0.75 ENST00000377810.8
MARK2
microtubule affinity regulating kinase 2
chr16_+_56451513 0.75 ENST00000562150.5
ENST00000561646.5
ENST00000566157.6
ENST00000568397.1
OGFOD1
2-oxoglutarate and iron dependent oxygenase domain containing 1
chr1_-_89126066 0.74 ENST00000370466.4
GBP2
guanylate binding protein 2
chrX_-_11265975 0.74 ENST00000303025.10
ENST00000657361.1
ARHGAP6
Rho GTPase activating protein 6
chr16_+_283157 0.73 ENST00000219406.11
ENST00000404312.5
ENST00000456379.1
PDIA2
protein disulfide isomerase family A member 2
chr4_+_89901979 0.72 ENST00000508372.1
MMRN1
multimerin 1
chr3_+_119468952 0.70 ENST00000476573.5
ENST00000295588.9
POGLUT1
protein O-glucosyltransferase 1
chr16_-_23641270 0.69 ENST00000568219.5
ENST00000261584.9
PALB2
partner and localizer of BRCA2
chr2_-_73642413 0.67 ENST00000272425.4
NAT8
N-acetyltransferase 8 (putative)
chr1_+_99646025 0.67 ENST00000263174.9
ENST00000605497.5
ENST00000615664.1
PALMD
palmdelphin
chr7_-_38265678 0.65 ENST00000443402.6
TRGC1
T cell receptor gamma constant 1
chr2_+_68974573 0.65 ENST00000673932.3
ENST00000377938.4
GKN1
gastrokine 1
chr8_-_81483226 0.59 ENST00000256104.5
FABP4
fatty acid binding protein 4
chr7_-_100119840 0.56 ENST00000437822.6
TAF6
TATA-box binding protein associated factor 6
chr11_+_24497155 0.55 ENST00000529015.5
ENST00000533227.5
LUZP2
leucine zipper protein 2
chr1_+_86547070 0.51 ENST00000370563.3
CLCA4
chloride channel accessory 4
chr16_+_86566821 0.50 ENST00000649859.1
FOXC2
forkhead box C2
chr8_+_28891304 0.49 ENST00000355231.9
HMBOX1
homeobox containing 1
chr1_-_27604176 0.49 ENST00000642416.1
AHDC1
AT-hook DNA binding motif containing 1
chr6_-_26027274 0.48 ENST00000377745.4
H4C2
H4 clustered histone 2
chr7_-_122098831 0.43 ENST00000681213.1
ENST00000679419.1
AASS
aminoadipate-semialdehyde synthase
chr15_-_72271244 0.42 ENST00000287196.13
PARP6
poly(ADP-ribose) polymerase family member 6
chr6_-_26043704 0.41 ENST00000615966.2
H2BC3
H2B clustered histone 3
chr1_-_115089414 0.40 ENST00000433172.3
ENST00000369515.6
ENST00000369516.7
TSPAN2
tetraspanin 2
chr2_-_55010348 0.39 ENST00000394609.6
RTN4
reticulon 4
chr1_-_27604135 0.39 ENST00000673934.1
ENST00000642245.1
AHDC1
AT-hook DNA binding motif containing 1
chr2_+_102355750 0.34 ENST00000233957.7
IL18R1
interleukin 18 receptor 1
chr1_+_182450132 0.32 ENST00000294854.13
RGSL1
regulator of G protein signaling like 1
chr5_+_141177790 0.31 ENST00000239444.4
ENST00000623995.1
PCDHB8
ENSG00000279472.1
protocadherin beta 8
novel transcript
chr20_+_44401269 0.31 ENST00000443598.6
ENST00000415691.2
HNF4A
hepatocyte nuclear factor 4 alpha
chr12_-_91111460 0.30 ENST00000266718.5
LUM
lumican
chr11_+_92969651 0.28 ENST00000257068.3
ENST00000528076.1
MTNR1B
melatonin receptor 1B
chr4_+_69931066 0.26 ENST00000246891.9
CSN1S1
casein alpha s1
chr6_+_29111560 0.25 ENST00000377169.2
OR2J3
olfactory receptor family 2 subfamily J member 3
chr17_-_3298360 0.22 ENST00000323404.2
OR3A1
olfactory receptor family 3 subfamily A member 1
chr9_+_34329545 0.17 ENST00000379158.7
NUDT2
nudix hydrolase 2
chr4_+_68447453 0.16 ENST00000305363.9
TMPRSS11E
transmembrane serine protease 11E
chr9_-_135499846 0.14 ENST00000429260.7
C9orf116
chromosome 9 open reading frame 116
chr2_+_44941695 0.07 ENST00000260653.5
SIX3
SIX homeobox 3
chr6_+_26199509 0.07 ENST00000356530.5
H2BC7
H2B clustered histone 7
chr18_+_58341038 0.04 ENST00000679791.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr13_-_99307387 0.01 ENST00000376414.5
GPR183
G protein-coupled receptor 183
chr7_-_81770122 0.01 ENST00000423064.7
HGF
hepatocyte growth factor
chr8_-_92017637 0.01 ENST00000422361.6
RUNX1T1
RUNX1 partner transcriptional co-repressor 1
chr8_+_75539893 0.00 ENST00000674002.1
HNF4G
hepatocyte nuclear factor 4 gamma

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 18.2 GO:0060221 retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
1.2 6.2 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.8 10.5 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.8 3.8 GO:0072143 mesangial cell development(GO:0072143) glomerular mesangial cell development(GO:0072144)
0.7 2.7 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.6 6.2 GO:0009449 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.5 19.9 GO:0008045 motor neuron axon guidance(GO:0008045)
0.5 1.5 GO:1904432 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) regulation of T cell antigen processing and presentation(GO:0002625) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) response to iron ion starvation(GO:1990641)
0.5 1.9 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.4 1.2 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.4 3.5 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.3 1.8 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.3 1.1 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
0.3 6.5 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.2 1.5 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180)
0.2 1.9 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.2 6.9 GO:0030517 negative regulation of axon extension(GO:0030517)
0.2 0.7 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.2 1.7 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.2 4.2 GO:0006829 zinc II ion transport(GO:0006829)
0.2 0.9 GO:0010746 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.1 0.4 GO:0033512 lysine biosynthetic process(GO:0009085) lysine biosynthetic process via aminoadipic acid(GO:0019878) L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.1 3.9 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 1.3 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.1 1.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 2.5 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.1 3.5 GO:0050912 detection of chemical stimulus involved in sensory perception of taste(GO:0050912)
0.1 3.0 GO:0061436 establishment of skin barrier(GO:0061436)
0.1 3.1 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.1 1.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 1.3 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.1 1.6 GO:0002323 natural killer cell activation involved in immune response(GO:0002323)
0.1 2.7 GO:0006349 regulation of gene expression by genetic imprinting(GO:0006349)
0.1 6.3 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.1 0.3 GO:0035655 interleukin-18-mediated signaling pathway(GO:0035655)
0.1 0.4 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.1 2.6 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 1.4 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.8 GO:0021859 pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.1 0.7 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.8 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 4.5 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 3.9 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.6 GO:0071285 cellular response to lithium ion(GO:0071285)
0.0 1.3 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 0.8 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 1.6 GO:0052646 alditol phosphate metabolic process(GO:0052646)
0.0 2.6 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 1.7 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.0 0.7 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.0 0.5 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 1.3 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 1.3 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.0 0.3 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 5.5 GO:0034605 cellular response to heat(GO:0034605)
0.0 3.6 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.0 0.9 GO:1901661 quinone metabolic process(GO:1901661)
0.0 1.1 GO:0042073 intraciliary transport(GO:0042073)
0.0 1.6 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 1.0 GO:0035904 aorta development(GO:0035904)
0.0 1.7 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.0 3.5 GO:2001235 positive regulation of apoptotic signaling pathway(GO:2001235)
0.0 0.8 GO:0051646 mitochondrion localization(GO:0051646)
0.0 0.7 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 2.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 2.0 GO:0000187 activation of MAPK activity(GO:0000187)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
1.1 3.3 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.8 10.5 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.6 1.8 GO:0033150 perinuclear theca(GO:0033011) cytoskeletal calyx(GO:0033150)
0.3 0.8 GO:0097441 basilar dendrite(GO:0097441)
0.2 1.5 GO:1990357 terminal web(GO:1990357)
0.2 20.1 GO:0031594 neuromuscular junction(GO:0031594)
0.2 1.3 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.1 1.9 GO:0005869 dynactin complex(GO:0005869)
0.1 0.8 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 1.1 GO:0005955 calcineurin complex(GO:0005955)
0.1 2.7 GO:0035861 site of double-strand break(GO:0035861)
0.1 1.7 GO:0035371 microtubule plus-end(GO:0035371)
0.1 1.6 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.1 0.8 GO:0097427 microtubule bundle(GO:0097427)
0.1 2.9 GO:0016235 aggresome(GO:0016235)
0.1 1.8 GO:0042101 T cell receptor complex(GO:0042101)
0.1 1.7 GO:0030057 desmosome(GO:0030057)
0.1 3.5 GO:0031201 SNARE complex(GO:0031201)
0.0 1.1 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.8 GO:0008091 spectrin(GO:0008091)
0.0 1.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.4 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 2.2 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.3 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 1.3 GO:0005801 cis-Golgi network(GO:0005801)
0.0 2.6 GO:0030175 filopodium(GO:0030175)
0.0 0.4 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 1.0 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 1.3 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 18.2 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
1.3 6.5 GO:0047273 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273)
1.2 6.2 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.6 1.7 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.4 6.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 19.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.4 4.0 GO:0005549 odorant binding(GO:0005549)
0.3 1.3 GO:0002046 opsin binding(GO:0002046)
0.3 4.7 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.3 3.5 GO:0008527 taste receptor activity(GO:0008527)
0.2 1.2 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.2 0.7 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.2 3.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 1.0 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.2 0.9 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.2 2.6 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 0.8 GO:0031544 peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.1 1.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 2.7 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 1.8 GO:0031543 peptidyl-proline dioxygenase activity(GO:0031543)
0.1 1.5 GO:0039706 co-receptor binding(GO:0039706)
0.1 0.8 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.1 1.8 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 0.3 GO:0042008 interleukin-18 receptor activity(GO:0042008)
0.1 0.7 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 9.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 1.6 GO:0005132 type I interferon receptor binding(GO:0005132)
0.1 1.6 GO:0003993 acid phosphatase activity(GO:0003993)
0.1 0.3 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 0.8 GO:0042731 PH domain binding(GO:0042731)
0.1 5.3 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 2.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 3.5 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 0.8 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 1.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 2.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.5 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.5 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 2.3 GO:0030552 cAMP binding(GO:0030552)
0.0 0.9 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.0 0.8 GO:0070513 death domain binding(GO:0070513)
0.0 0.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.5 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 1.9 GO:0030507 spectrin binding(GO:0030507)
0.0 0.8 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 1.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 5.5 GO:0005516 calmodulin binding(GO:0005516)
0.0 1.9 GO:0003774 motor activity(GO:0003774)
0.0 2.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.4 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.2 GO:0004551 nucleotide diphosphatase activity(GO:0004551)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 18.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.3 22.3 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.2 10.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.5 PID ARF 3PATHWAY Arf1 pathway
0.0 2.7 PID IL23 PATHWAY IL23-mediated signaling events
0.0 2.5 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 1.1 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 3.1 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.9 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.9 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 3.3 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 1.6 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.8 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.8 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 3.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.7 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.7 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.8 PID LKB1 PATHWAY LKB1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 6.2 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.4 10.5 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 3.1 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 21.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.2 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 2.6 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.7 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 6.2 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.3 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 5.4 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 2.6 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 0.9 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 1.6 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 1.3 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.8 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 2.8 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.7 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 1.1 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 1.6 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.6 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.8 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.8 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.7 REACTOME PRE NOTCH EXPRESSION AND PROCESSING Genes involved in Pre-NOTCH Expression and Processing