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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for LHX6
Z-value: 0.61
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Transcription factors associated with LHX6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| LHX6 | hg38_v1_chr9_-_122228845_122228967, hg38_v1_chr9_-_122227525_122227586 | 0.42 | 5.7e-11 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of LHX6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 13.5 | GO:0071711 | basement membrane organization(GO:0071711) |
| 1.2 | 10.9 | GO:1903898 | negative regulation of PERK-mediated unfolded protein response(GO:1903898) negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912) |
| 0.8 | 10.8 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.9 | 10.2 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 2.3 | 9.3 | GO:0044828 | negative regulation by host of viral genome replication(GO:0044828) |
| 0.3 | 9.0 | GO:0007141 | male meiosis I(GO:0007141) |
| 0.3 | 8.4 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.1 | 8.2 | GO:0006458 | 'de novo' protein folding(GO:0006458) |
| 0.6 | 8.0 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 1.1 | 6.9 | GO:0071896 | protein localization to adherens junction(GO:0071896) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.7 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 11.2 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.6 | 10.9 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 9.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 2.3 | 9.3 | GO:0002945 | cyclin K-CDK13 complex(GO:0002945) |
| 2.3 | 9.0 | GO:0097123 | cyclin A1-CDK2 complex(GO:0097123) |
| 0.6 | 8.0 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.3 | 6.9 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.5 | 6.6 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.1 | 5.9 | GO:0005905 | clathrin-coated pit(GO:0005905) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 28.5 | GO:0000982 | transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) |
| 0.2 | 21.3 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 11.8 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 1.1 | 10.2 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.1 | 9.6 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.4 | 9.3 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 1.4 | 8.2 | GO:0000285 | 1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285) |
| 0.0 | 7.9 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 7.4 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.1 | 6.6 | GO:0004532 | exoribonuclease activity(GO:0004532) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 13.5 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.2 | 13.3 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.5 | 9.0 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.2 | 8.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 8.1 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.1 | 5.1 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.2 | 5.0 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.2 | 5.0 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 4.7 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 4.5 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 14.4 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.3 | 12.2 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.3 | 8.0 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.6 | 6.6 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.1 | 5.1 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 5.0 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 4.8 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 3.7 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.2 | 3.6 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.1 | 3.5 | REACTOME FGFR LIGAND BINDING AND ACTIVATION | Genes involved in FGFR ligand binding and activation |