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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for LHX8
Z-value: 0.68
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Transcription factors associated with LHX8
Network of associatons between targets according to the STRING database.
First level regulatory network of LHX8
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_28282086 Show fit | 9.82 |
ENST00000375719.7
ENST00000375732.5 |
membrane palmitoylated protein 7 |
|
| chr18_-_14132423 Show fit | 7.10 |
ENST00000589498.5
ENST00000590202.3 |
zinc finger protein 519 |
|
| chr6_+_29301701 Show fit | 6.75 |
ENST00000641895.1
|
olfactory receptor family 14 subfamily J member 1 |
|
| chr11_-_5227063 Show fit | 6.66 |
ENST00000335295.4
ENST00000485743.1 ENST00000647020.1 |
hemoglobin subunit beta |
|
| chr22_+_29480211 Show fit | 6.61 |
ENST00000310624.7
|
neurofilament heavy |
|
| chr18_+_74148508 Show fit | 5.62 |
ENST00000580087.5
ENST00000169551.11 |
translocase of inner mitochondrial membrane 21 |
|
| chr7_-_78489900 Show fit | 5.61 |
ENST00000636039.1
|
membrane associated guanylate kinase, WW and PDZ domain containing 2 |
|
| chr2_-_151261839 Show fit | 5.59 |
ENST00000331426.6
|
RNA binding motif protein 43 |
|
| chr19_+_21505585 Show fit | 5.29 |
ENST00000358491.9
ENST00000597078.5 |
zinc finger protein 429 |
|
| chr19_+_21505656 Show fit | 5.28 |
ENST00000618549.1
|
zinc finger protein 429 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.2 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 1.6 | 9.8 | GO:0071896 | protein localization to adherens junction(GO:0071896) |
| 0.4 | 8.0 | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) |
| 1.8 | 7.1 | GO:0051037 | regulation of transcription involved in meiotic cell cycle(GO:0051037) |
| 2.2 | 6.7 | GO:0030185 | nitric oxide transport(GO:0030185) |
| 1.7 | 6.6 | GO:0033693 | neurofilament bundle assembly(GO:0033693) |
| 0.1 | 6.0 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.6 | 5.6 | GO:0003402 | planar cell polarity pathway involved in axis elongation(GO:0003402) |
| 0.4 | 5.6 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) |
| 0.4 | 5.1 | GO:0015074 | DNA integration(GO:0015074) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.1 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 1.7 | 6.7 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.4 | 6.6 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.0 | 6.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.4 | 5.6 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
| 0.4 | 5.6 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 1.6 | 4.9 | GO:0005760 | gamma DNA polymerase complex(GO:0005760) |
| 0.0 | 4.9 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.7 | 4.0 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.0 | 3.7 | GO:0005811 | lipid particle(GO:0005811) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.8 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.9 | 9.5 | GO:0005549 | odorant binding(GO:0005549) |
| 0.1 | 8.2 | GO:0035591 | signaling adaptor activity(GO:0035591) |
| 0.5 | 8.0 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.7 | 5.6 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.1 | 5.5 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.7 | 5.2 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 1.0 | 4.9 | GO:0016890 | site-specific endodeoxyribonuclease activity, specific for altered base(GO:0016890) |
| 0.4 | 4.7 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.1 | 4.3 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.0 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.2 | 4.3 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 2.8 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.9 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 1.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.4 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 1.4 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 1.1 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 1.1 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 0.9 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.7 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 9.8 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.2 | 8.0 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.1 | 7.0 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 5.6 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.3 | 4.9 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.2 | 4.3 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.1 | 3.7 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 3.5 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 3.3 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |