ISMARA results: LMX1B_MNX1

Project

GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation

Downloads

Results for LMX1B_MNX1_RAX2

Z-value: 0.59

Motif logo

Transcription factors associated with LMX1B_MNX1_RAX2

Gene Symbol	Gene ID	Gene Info
LMX1B Ensembl NCBI GeneCards UniProt	ENSG00000136944.19	LMX1B
MNX1 Ensembl NCBI GeneCards UniProt	ENSG00000130675.15	MNX1
RAX2 Ensembl NCBI GeneCards UniProt	ENSG00000173976.16	RAX2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
LMX1B	hg38_v1_chr9_+_126613922_126613946	-0.15	2.7e-02	Click!
RAX2	hg38_v1_chr19_-_3772211_3772238	-0.08	2.3e-01	Click!
MNX1	hg38_v1_chr7_-_157010615_157010668	0.07	2.9e-01	Click!

Activity profile of LMX1B_MNX1_RAX2 motif

Sorted Z-values of LMX1B_MNX1_RAX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of LMX1B_MNX1_RAX2

View svg image
View png image

Top targets:

Search:

Show entries

Promoter	Score	Transcript	Gene	Gene Info
chr4_+_168497066 Show fit	34.13	ENST00000261509.10	PALLD Ensembl NCBI GeneCards UniProt Show fit	palladin, cytoskeletal associated protein
chr4_+_168497044 Show fit	28.60	ENST00000505667.6	PALLD Ensembl NCBI GeneCards UniProt Show fit	palladin, cytoskeletal associated protein
chr7_+_134779625 Show fit	11.49	ENST00000454108.5 ENST00000361675.7	CALD1 Ensembl NCBI GeneCards UniProt Show fit	caldesmon 1
chr2_+_186590022 Show fit	11.15	ENST00000261023.8 ENST00000374907.7	ITGAV Ensembl NCBI GeneCards UniProt Show fit	integrin subunit alpha V
chr7_+_134779663 Show fit	10.93	ENST00000361901.6	CALD1 Ensembl NCBI GeneCards UniProt Show fit	caldesmon 1
chr12_-_52573816 Show fit	9.89	ENST00000549343.5 ENST00000305620.3	KRT74 Ensembl NCBI GeneCards UniProt Show fit	keratin 74
chr1_-_93681829 Show fit	9.62	ENST00000260502.11	BCAR3 Ensembl NCBI GeneCards UniProt Show fit	BCAR3 adaptor protein, NSP family member
chr15_-_37101205 Show fit	9.19	ENST00000338564.9 ENST00000558313.5 ENST00000340545.9	MEIS2 Ensembl NCBI GeneCards UniProt Show fit	Meis homeobox 2
chr1_+_67685170 Show fit	8.28	ENST00000370985.4 ENST00000370986.9 ENST00000650283.1 ENST00000648742.1	GADD45A Ensembl NCBI GeneCards UniProt Show fit	growth arrest and DNA damage inducible alpha
chrX_-_10833643 Show fit	7.89	ENST00000380785.5 ENST00000380787.5	MID1 Ensembl NCBI GeneCards UniProt Show fit	midline 1

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
3.3	62.7	GO:0003334	keratinocyte development(GO:0003334)
3.7	11.2	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.2	9.9	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.3	9.4	GO:0002089	lens morphogenesis in camera-type eye(GO:0002089)
0.7	9.0	GO:0048743	positive regulation of skeletal muscle fiber development(GO:0048743)
0.1	8.7	GO:0008542	visual learning(GO:0008542)
0.3	8.5	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.6	7.9	GO:0035372	protein localization to microtubule(GO:0035372)
1.5	7.6	GO:2000542	negative regulation of gastrulation(GO:2000542)
0.2	7.4	GO:0032467	positive regulation of cytokinesis(GO:0032467)

Showing 1 to 10 of 121 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.2	62.1	GO:0002102	podosome(GO:0002102)
1.5	22.4	GO:0030478	actin cap(GO:0030478)
0.0	15.7	GO:0005912	adherens junction(GO:0005912)
0.0	14.4	GO:0016607	nuclear speck(GO:0016607)
0.3	12.3	GO:0045095	keratin filament(GO:0045095)
0.2	12.1	GO:0005881	cytoplasmic microtubule(GO:0005881)
3.7	11.2	GO:0034686	integrin alphav-beta8 complex(GO:0034686)
0.0	10.9	GO:0005802	trans-Golgi network(GO:0005802)
0.1	9.7	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)
2.5	7.6	GO:0005588	collagen type V trimer(GO:0005588)

Showing 1 to 10 of 55 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
2.7	63.2	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.8	22.4	GO:0005523	tropomyosin binding(GO:0005523)
0.0	11.3	GO:0003714	transcription corepressor activity(GO:0003714)
2.8	11.0	GO:1990430	extracellular matrix protein binding(GO:1990430)
2.0	9.9	GO:1990254	keratin filament binding(GO:1990254)
0.1	9.6	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.4	8.6	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.1	8.3	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	7.8	GO:0047485	protein N-terminus binding(GO:0047485)
0.2	6.5	GO:0005388	calcium-transporting ATPase activity(GO:0005388)

Showing 1 to 10 of 94 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	11.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2	9.6	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.1	8.3	PID AURORA A PATHWAY	Aurora A signaling
0.1	7.7	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.2	7.6	NABA COLLAGENS	Genes encoding collagen proteins
0.1	7.0	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.1	5.3	PID ILK PATHWAY	Integrin-linked kinase signaling
0.1	4.5	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	3.8	PID AURORA B PATHWAY	Aurora B signaling
0.1	3.2	NABA PROTEOGLYCANS	Genes encoding proteoglycans

Showing 1 to 10 of 27 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	24.5	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.7	11.2	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.5	8.6	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.3	8.6	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.1	7.6	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.1	6.6	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.2	5.3	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	4.8	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.1	4.4	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	4.3	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)

Showing 1 to 10 of 46 entries

Results for LMX1B_MNX1_RAX2

Z-value: 0.59

Motif logo

Transcription factors associated with LMX1B_MNX1_RAX2

Activity-expression correlation:

Activity profile of LMX1B_MNX1_RAX2 motif

Sorted Z-values of LMX1B_MNX1_RAX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of LMX1B_MNX1_RAX2

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: