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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MAFF_MAFG
Z-value: 0.92
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Transcription factors associated with MAFF_MAFG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MAFG | hg38_v1_chr17_-_81923532_81923547, hg38_v1_chr17_-_81927699_81927748 | 0.10 | 1.2e-01 | Click! |
| MAFF | hg38_v1_chr22_+_38201932_38202014 | 0.04 | 5.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAFF_MAFG
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrY_+_2841594 Show fit | 53.95 |
ENST00000250784.13
|
ribosomal protein S4 Y-linked 1 |
|
| chrY_+_2841864 Show fit | 25.78 |
ENST00000430575.1
|
ribosomal protein S4 Y-linked 1 |
|
| chr6_+_33075952 Show fit | 21.14 |
ENST00000418931.7
|
major histocompatibility complex, class II, DP beta 1 |
|
| chr11_-_5227063 Show fit | 14.97 |
ENST00000335295.4
ENST00000485743.1 ENST00000647020.1 |
hemoglobin subunit beta |
|
| chrY_+_20756103 Show fit | 11.56 |
ENST00000629237.2
|
ribosomal protein S4 Y-linked 2 |
|
| chr1_+_22653228 Show fit | 10.39 |
ENST00000509305.6
|
complement C1q B chain |
|
| chr1_+_22653189 Show fit | 9.80 |
ENST00000432749.6
|
complement C1q B chain |
|
| chr11_+_60280531 Show fit | 9.76 |
ENST00000532114.6
|
membrane spanning 4-domains A4A |
|
| chr2_-_88992903 Show fit | 9.68 |
ENST00000495489.1
|
immunoglobulin kappa variable 1-8 |
|
| chr5_-_42811884 Show fit | 9.59 |
ENST00000514985.6
ENST00000511224.5 ENST00000507920.5 ENST00000510965.1 |
selenoprotein P |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 67.4 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.4 | 56.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.3 | 21.1 | GO:0032729 | positive regulation of interferon-gamma production(GO:0032729) |
| 0.1 | 20.3 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.1 | 17.9 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 5.0 | 15.0 | GO:0030185 | nitric oxide transport(GO:0030185) |
| 0.1 | 13.8 | GO:0002250 | adaptive immune response(GO:0002250) |
| 1.7 | 13.3 | GO:0070235 | regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.0 | 11.2 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 0.1 | 9.9 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 77.7 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 22.3 | GO:0005615 | extracellular space(GO:0005615) |
| 1.1 | 21.1 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 5.0 | 20.2 | GO:0005602 | complement component C1 complex(GO:0005602) |
| 0.1 | 15.7 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 3.7 | 15.0 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.6 | 11.8 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.1 | 11.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 9.4 | GO:0000922 | spindle pole(GO:0000922) |
| 0.2 | 9.3 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 85.4 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.3 | 65.9 | GO:0003823 | antigen binding(GO:0003823) |
| 0.7 | 27.3 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.1 | 21.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.0 | 20.3 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.0 | 15.6 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 2.1 | 15.0 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 1.5 | 13.3 | GO:0043426 | MRF binding(GO:0043426) |
| 0.8 | 9.6 | GO:0008430 | selenium binding(GO:0008430) |
| 1.9 | 9.5 | GO:0004464 | leukotriene-C4 synthase activity(GO:0004464) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 30.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 20.6 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 15.7 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.2 | 14.0 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.2 | 12.5 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.2 | 11.9 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 4.7 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 4.4 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.4 | 4.1 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.1 | 4.1 | PID ARF6 PATHWAY | Arf6 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 76.5 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.3 | 21.9 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 21.3 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 1.0 | 21.1 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 1.8 | 20.2 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.1 | 16.5 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.3 | 10.0 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.3 | 8.9 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.3 | 6.2 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.4 | 5.8 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |