Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for MAFK
Z-value: 1.31
Motif logo
Transcription factors associated with MAFK
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MAFK | hg38_v1_chr7_+_1530684_1530726 | 0.31 | 4.1e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAFK
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 346.3 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.7 | 111.1 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.2 | 48.5 | GO:0002250 | adaptive immune response(GO:0002250) |
| 11.2 | 33.6 | GO:0002378 | immunoglobulin biosynthetic process(GO:0002378) |
| 0.1 | 33.4 | GO:0006413 | translational initiation(GO:0006413) |
| 0.9 | 32.3 | GO:0032461 | positive regulation of protein oligomerization(GO:0032461) |
| 0.6 | 26.1 | GO:0032731 | positive regulation of interleukin-1 beta production(GO:0032731) |
| 1.9 | 25.0 | GO:2001300 | lipoxin metabolic process(GO:2001300) |
| 0.5 | 23.0 | GO:0032729 | positive regulation of interferon-gamma production(GO:0032729) |
| 1.0 | 22.9 | GO:0030889 | negative regulation of B cell proliferation(GO:0030889) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 176.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 2.7 | 128.7 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 110.5 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 67.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.3 | 43.9 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 1.9 | 36.9 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.3 | 35.8 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.7 | 17.5 | GO:0001891 | phagocytic cup(GO:0001891) |
| 1.6 | 17.4 | GO:0060171 | stereocilium membrane(GO:0060171) |
| 0.2 | 17.3 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 382.4 | GO:0003823 | antigen binding(GO:0003823) |
| 2.4 | 141.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.8 | 28.4 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.9 | 27.3 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 3.0 | 23.6 | GO:0023029 | MHC class Ib protein binding(GO:0023029) |
| 4.5 | 22.6 | GO:0004464 | leukotriene-C4 synthase activity(GO:0004464) |
| 0.6 | 22.4 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 2.1 | 19.1 | GO:0043426 | MRF binding(GO:0043426) |
| 3.8 | 18.9 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.1 | 17.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 38.5 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.2 | 28.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.4 | 22.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 21.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 18.9 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 13.5 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 11.7 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.2 | 9.8 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.2 | 9.5 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 9.3 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 72.8 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.7 | 58.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 19.3 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.6 | 18.3 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.4 | 14.8 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.3 | 14.8 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.2 | 14.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 1.3 | 13.8 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.3 | 12.6 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.2 | 12.6 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |