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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MAF_NRL
Z-value: 1.35
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Transcription factors associated with MAF_NRL
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NRL | hg38_v1_chr14_-_24114913_24115010, hg38_v1_chr14_-_24084625_24084641 | 0.66 | 9.4e-29 | Click! |
| MAF | hg38_v1_chr16_-_79599902_79600058 | 0.59 | 3.6e-22 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAF_NRL
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.7 | 127.7 | GO:0015671 | oxygen transport(GO:0015671) |
| 1.3 | 94.0 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.7 | 50.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 9.1 | 36.6 | GO:0010900 | negative regulation of phosphatidylcholine catabolic process(GO:0010900) |
| 0.4 | 30.2 | GO:0032729 | positive regulation of interferon-gamma production(GO:0032729) |
| 5.7 | 28.3 | GO:0014738 | regulation of muscle hyperplasia(GO:0014738) |
| 6.2 | 24.9 | GO:0010982 | regulation of high-density lipoprotein particle clearance(GO:0010982) |
| 1.2 | 24.8 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 3.4 | 23.7 | GO:1904098 | regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100) |
| 3.2 | 22.7 | GO:0071279 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) cellular response to cobalt ion(GO:0071279) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 145.5 | GO:0005615 | extracellular space(GO:0005615) |
| 1.7 | 91.3 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 17.8 | 71.1 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 4.2 | 54.9 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 2.3 | 44.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.3 | 41.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 2.0 | 36.6 | GO:0042627 | chylomicron(GO:0042627) |
| 0.8 | 34.1 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 4.4 | 30.9 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 2.9 | 23.5 | GO:0005579 | membrane attack complex(GO:0005579) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.9 | 132.8 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 1.5 | 91.6 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.5 | 62.9 | GO:0003823 | antigen binding(GO:0003823) |
| 0.2 | 51.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.4 | 41.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 6.1 | 36.6 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 6.2 | 30.9 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 2.0 | 27.4 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 3.4 | 23.7 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
| 0.5 | 23.2 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 82.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 32.7 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 28.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.4 | 20.8 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.1 | 19.5 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.6 | 19.2 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.3 | 17.2 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 14.4 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.0 | 12.2 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.2 | 11.9 | PID SHP2 PATHWAY | SHP2 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 36.8 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.8 | 34.9 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 1.4 | 30.9 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 1.0 | 23.0 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 1.1 | 22.6 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.7 | 18.1 | REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | Genes involved in Thromboxane signalling through TP receptor |
| 0.2 | 16.0 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.8 | 15.5 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.2 | 14.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.4 | 13.5 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |