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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MAX_TFEB
Z-value: 1.67
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Transcription factors associated with MAX_TFEB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MAX | hg38_v1_chr14_-_65102468_65102695 | 0.40 | 9.4e-10 | Click! |
| TFEB | hg38_v1_chr6_-_41733690_41733868 | -0.14 | 4.6e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAX_TFEB
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 83.3 | 416.6 | GO:1904637 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
| 1.8 | 271.5 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 2.8 | 169.3 | GO:0070911 | global genome nucleotide-excision repair(GO:0070911) |
| 2.3 | 145.4 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 27.1 | 135.7 | GO:0033387 | putrescine biosynthetic process from ornithine(GO:0033387) |
| 0.9 | 116.5 | GO:0006364 | rRNA processing(GO:0006364) |
| 11.0 | 110.3 | GO:1904715 | negative regulation of chaperone-mediated autophagy(GO:1904715) |
| 5.5 | 109.6 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 10.8 | 97.3 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 6.8 | 88.0 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 69.4 | 416.6 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 2.0 | 215.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.1 | 207.9 | GO:0005840 | ribosome(GO:0005840) |
| 1.1 | 161.3 | GO:0016605 | PML body(GO:0016605) |
| 1.2 | 137.6 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 15.3 | 122.8 | GO:0098575 | lumenal side of lysosomal membrane(GO:0098575) |
| 2.4 | 114.1 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 11.0 | 109.6 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 5.3 | 101.2 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.7 | 92.2 | GO:0005882 | intermediate filament(GO:0005882) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.8 | 420.6 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 1.0 | 198.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 3.3 | 152.4 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 1.7 | 137.7 | GO:0005507 | copper ion binding(GO:0005507) |
| 2.6 | 128.8 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 13.8 | 110.1 | GO:0004308 | exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) |
| 12.2 | 109.6 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 1.7 | 107.2 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 6.7 | 93.4 | GO:0031386 | protein tag(GO:0031386) |
| 21.5 | 86.0 | GO:0008311 | double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 425.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 20.9 | 417.4 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 2.9 | 147.3 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 1.4 | 114.6 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 1.2 | 99.8 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 1.9 | 98.5 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.3 | 91.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.1 | 86.7 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 1.6 | 83.8 | PID ATR PATHWAY | ATR signaling pathway |
| 1.2 | 55.5 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 416.9 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 11.5 | 415.5 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 1.3 | 204.6 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 2.0 | 163.4 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 6.9 | 137.3 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 6.9 | 137.0 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 2.2 | 129.4 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 1.2 | 121.3 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 2.1 | 110.5 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 4.8 | 109.6 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |