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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MAZ_ZNF281_GTF2F1
Z-value: 2.79
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Transcription factors associated with MAZ_ZNF281_GTF2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GTF2F1 | hg38_v1_chr19_-_6393131_6393172 | -0.48 | 8.9e-14 | Click! |
| MAZ | hg38_v1_chr16_+_29807536_29807586 | -0.43 | 2.4e-11 | Click! |
| ZNF281 | hg38_v1_chr1_-_200410052_200410063, hg38_v1_chr1_-_200410001_200410049, hg38_v1_chr1_-_200409976_200410000 | -0.26 | 1.1e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAZ_ZNF281_GTF2F1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.8 | 375.2 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 14.5 | 247.2 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 1.3 | 224.7 | GO:0071805 | cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805) |
| 12.5 | 211.7 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 2.8 | 203.0 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 12.0 | 192.2 | GO:0070445 | oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) |
| 10.5 | 168.6 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 13.2 | 145.5 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 3.8 | 140.1 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 3.0 | 134.0 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 912.2 | GO:0031224 | intrinsic component of membrane(GO:0031224) |
| 2.7 | 632.2 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 3.1 | 486.2 | GO:0043204 | perikaryon(GO:0043204) |
| 2.6 | 456.6 | GO:0030426 | growth cone(GO:0030426) |
| 4.8 | 311.8 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 1.6 | 279.2 | GO:0098793 | presynapse(GO:0098793) |
| 3.7 | 259.2 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 14.5 | 232.4 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 2.2 | 207.5 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 1.3 | 202.7 | GO:0031225 | anchored component of membrane(GO:0031225) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.1 | 250.1 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 7.5 | 225.7 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 6.6 | 203.5 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 1.7 | 196.8 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 3.3 | 188.0 | GO:0030507 | spectrin binding(GO:0030507) |
| 46.7 | 187.0 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.5 | 180.4 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 8.3 | 166.2 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 6.2 | 129.6 | GO:0043274 | phospholipase binding(GO:0043274) |
| 10.0 | 129.4 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 156.4 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 2.4 | 132.1 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 2.4 | 128.7 | ST GA13 PATHWAY | G alpha 13 Pathway |
| 1.9 | 100.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.7 | 100.2 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 2.1 | 96.3 | PID LKB1 PATHWAY | LKB1 signaling events |
| 1.3 | 80.7 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 2.7 | 75.7 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.9 | 62.7 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 1.3 | 52.4 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.9 | 354.4 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 3.4 | 262.0 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 12.6 | 251.8 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 5.5 | 236.9 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 1.8 | 231.3 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 6.0 | 227.3 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 6.3 | 169.0 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 4.0 | 166.3 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 2.1 | 147.2 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 2.7 | 144.0 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |