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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MBD2
Z-value: 0.83
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Transcription factors associated with MBD2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MBD2 | hg38_v1_chr18_-_54224578_54224689 | -0.10 | 1.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MBD2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.1 | GO:0043401 | steroid hormone mediated signaling pathway(GO:0043401) |
| 0.1 | 11.2 | GO:0042035 | regulation of cytokine biosynthetic process(GO:0042035) |
| 1.3 | 9.4 | GO:1904100 | regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100) |
| 0.2 | 8.7 | GO:0010762 | regulation of fibroblast migration(GO:0010762) |
| 1.2 | 8.6 | GO:0060154 | cellular process regulating host cell cycle in response to virus(GO:0060154) |
| 1.9 | 7.8 | GO:0033306 | phytol metabolic process(GO:0033306) fatty alcohol metabolic process(GO:1903173) |
| 0.2 | 7.1 | GO:0098534 | centriole assembly(GO:0098534) |
| 1.1 | 6.8 | GO:0035602 | fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) |
| 0.2 | 6.7 | GO:0007184 | SMAD protein import into nucleus(GO:0007184) |
| 0.1 | 6.7 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 43.2 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.2 | 14.2 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.3 | 9.3 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.7 | 8.9 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.0 | 8.5 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 8.0 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.0 | 7.6 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.2 | 6.5 | GO:0071011 | precatalytic spliceosome(GO:0071011) |
| 0.1 | 6.5 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.2 | 6.4 | GO:0034451 | centriolar satellite(GO:0034451) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.3 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 16.9 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.3 | 12.2 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.1 | 11.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.8 | 9.8 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 1.3 | 9.4 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
| 0.3 | 9.2 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.0 | 9.1 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.7 | 8.9 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 2.6 | 7.8 | GO:0046577 | long-chain-alcohol oxidase activity(GO:0046577) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.4 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 10.6 | PID FGF PATHWAY | FGF signaling pathway |
| 0.2 | 9.7 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.4 | 8.9 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.1 | 8.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.5 | 8.0 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 7.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 7.1 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.2 | 6.9 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.2 | 6.2 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.3 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 11.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 10.8 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.4 | 9.8 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 9.2 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 0.5 | 8.0 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.2 | 7.8 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.3 | 7.7 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.2 | 7.2 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.3 | 6.6 | REACTOME FGFR2C LIGAND BINDING AND ACTIVATION | Genes involved in FGFR2c ligand binding and activation |