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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MEF2B
Z-value: 0.72
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Transcription factors associated with MEF2B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MEF2B | hg38_v1_chr19_-_19192122_19192165 | 0.21 | 2.0e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MEF2B
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 35.2 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.7 | 31.7 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.1 | 21.2 | GO:1900034 | regulation of cellular response to heat(GO:1900034) |
| 2.4 | 19.4 | GO:0061709 | reticulophagy(GO:0061709) |
| 0.0 | 17.7 | GO:0031175 | neuron projection development(GO:0031175) |
| 3.5 | 17.4 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.1 | 16.4 | GO:1990823 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 1.6 | 14.1 | GO:0070315 | G1 to G0 transition involved in cell differentiation(GO:0070315) |
| 4.5 | 13.5 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.1 | 12.8 | GO:0061045 | negative regulation of wound healing(GO:0061045) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 69.0 | GO:0030426 | growth cone(GO:0030426) |
| 0.4 | 26.0 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.3 | 19.4 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 4.4 | 17.4 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.1 | 14.6 | GO:0030315 | T-tubule(GO:0030315) |
| 2.7 | 13.5 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.1 | 11.7 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.8 | 11.3 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.4 | 9.0 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.4 | 8.6 | GO:0005861 | troponin complex(GO:0005861) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.1 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 21.2 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.6 | 17.4 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 16.5 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.4 | 16.4 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.9 | 15.3 | GO:0031432 | titin binding(GO:0031432) |
| 0.1 | 14.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 2.7 | 13.5 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.5 | 13.4 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.6 | 9.7 | GO:0003680 | AT DNA binding(GO:0003680) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 32.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 16.5 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.2 | 13.5 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.3 | 13.1 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 12.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 11.8 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 10.3 | PID NFAT 3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| 0.2 | 7.3 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.1 | 6.6 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 5.3 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 37.1 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.3 | 17.1 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.3 | 14.0 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.2 | 7.9 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.2 | 7.3 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.1 | 5.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 5.3 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.2 | 4.9 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 4.6 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 3.9 | REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR | Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR) |