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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MEF2C
Z-value: 1.09
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Transcription factors associated with MEF2C
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MEF2C | hg38_v1_chr5_-_88883199_88883227 | -0.08 | 2.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MEF2C
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_110920710 Show fit | 37.02 |
ENST00000546404.1
|
myosin light chain 2 |
|
| chr12_-_110920568 Show fit | 36.73 |
ENST00000548438.1
ENST00000228841.15 |
myosin light chain 2 |
|
| chr11_+_1838970 Show fit | 26.47 |
ENST00000381911.6
|
troponin I2, fast skeletal type |
|
| chr22_-_35617321 Show fit | 25.25 |
ENST00000397326.7
ENST00000442617.1 |
myoglobin |
|
| chr11_-_19202004 Show fit | 23.36 |
ENST00000648719.1
|
cysteine and glycine rich protein 3 |
|
| chr2_-_210303608 Show fit | 21.57 |
ENST00000341685.8
|
myosin light chain 1 |
|
| chr17_+_39665340 Show fit | 20.95 |
ENST00000578283.1
ENST00000309889.3 |
titin-cap |
|
| chr17_+_4951758 Show fit | 20.94 |
ENST00000518175.1
|
enolase 3 |
|
| chr11_-_19201976 Show fit | 20.92 |
ENST00000647990.1
ENST00000649235.1 ENST00000265968.9 ENST00000649842.1 |
cysteine and glycine rich protein 3 |
|
| chr11_+_1839602 Show fit | 19.68 |
ENST00000617947.4
ENST00000252898.11 |
troponin I2, fast skeletal type |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 140.8 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 6.7 | 73.8 | GO:0098735 | positive regulation of the force of heart contraction(GO:0098735) |
| 13.0 | 65.2 | GO:0035995 | detection of muscle stretch(GO:0035995) |
| 0.6 | 45.4 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 3.7 | 44.7 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.9 | 26.7 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 2.8 | 25.2 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 0.9 | 25.1 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.6 | 24.1 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.6 | 20.9 | GO:0061718 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 149.7 | GO:0030018 | Z disc(GO:0030018) |
| 5.1 | 107.0 | GO:0005861 | troponin complex(GO:0005861) |
| 2.1 | 78.8 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 6.4 | 77.3 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 37.2 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.9 | 29.3 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 26.3 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 23.9 | GO:0005924 | cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925) |
| 2.6 | 20.9 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 1.4 | 17.7 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.7 | 99.7 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 6.0 | 83.6 | GO:0031014 | troponin T binding(GO:0031014) |
| 3.2 | 68.0 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 4.5 | 49.5 | GO:0031433 | telethonin binding(GO:0031433) |
| 0.2 | 38.8 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 27.3 | GO:0003779 | actin binding(GO:0003779) |
| 1.7 | 25.2 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.3 | 23.8 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.9 | 23.4 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 10.5 | 20.9 | GO:0051373 | FATZ binding(GO:0051373) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 73.8 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.6 | 22.7 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.2 | 19.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.2 | 13.8 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.1 | 11.7 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.1 | 10.7 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.1 | 10.3 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 7.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 6.5 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.5 | 6.3 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 258.9 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.9 | 52.0 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.9 | 24.1 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.2 | 13.8 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.4 | 12.6 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.1 | 9.2 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.3 | 8.1 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.5 | 6.9 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 6.7 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.3 | 6.4 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |