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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MEF2D_MEF2A
Z-value: 1.73
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Transcription factors associated with MEF2D_MEF2A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MEF2D | hg38_v1_chr1_-_156490599_156490625, hg38_v1_chr1_-_156500763_156500851 | 0.54 | 3.2e-18 | Click! |
| MEF2A | hg38_v1_chr15_+_99565950_99566038 | 0.23 | 7.4e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MEF2D_MEF2A
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 117.1 | GO:0033275 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 6.8 | 116.1 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 15.4 | 92.4 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 14.3 | 71.3 | GO:0035995 | detection of muscle stretch(GO:0035995) |
| 0.5 | 70.8 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.3 | 63.2 | GO:0050806 | positive regulation of synaptic transmission(GO:0050806) |
| 3.1 | 62.0 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 4.3 | 60.5 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 5.0 | 60.3 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 4.8 | 52.7 | GO:0098735 | positive regulation of the force of heart contraction(GO:0098735) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 176.3 | GO:0030426 | growth cone(GO:0030426) |
| 0.8 | 157.6 | GO:0030018 | Z disc(GO:0030018) |
| 2.6 | 103.6 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 4.9 | 78.9 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 4.2 | 75.5 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 3.7 | 63.2 | GO:0005861 | troponin complex(GO:0005861) |
| 1.0 | 59.4 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.3 | 57.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.5 | 51.9 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.2 | 51.9 | GO:0043209 | myelin sheath(GO:0043209) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 98.5 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 3.8 | 75.2 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 1.9 | 73.1 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.1 | 64.5 | GO:0005509 | calcium ion binding(GO:0005509) |
| 4.2 | 62.3 | GO:0031432 | titin binding(GO:0031432) |
| 15.5 | 62.0 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 5.3 | 58.1 | GO:0031433 | telethonin binding(GO:0031433) |
| 3.7 | 52.1 | GO:0031014 | troponin T binding(GO:0031014) |
| 3.5 | 49.4 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 2.6 | 48.6 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 133.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.7 | 109.1 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 1.6 | 67.6 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.5 | 67.4 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 3.1 | 52.7 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.7 | 43.7 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.6 | 40.5 | PID FGF PATHWAY | FGF signaling pathway |
| 0.4 | 32.8 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.8 | 29.7 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.5 | 24.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 237.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 1.9 | 43.0 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.3 | 42.0 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.5 | 39.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.9 | 32.8 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 1.2 | 27.9 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 27.8 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 2.1 | 26.7 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.9 | 24.8 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.4 | 23.2 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |