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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MEIS1
Z-value: 1.18
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Transcription factors associated with MEIS1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MEIS1 | hg38_v1_chr2_+_66435116_66435135, hg38_v1_chr2_+_66435558_66435686, hg38_v1_chr2_+_66439294_66439330 | -0.01 | 9.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MEIS1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 44.5 | GO:0003322 | pancreatic A cell development(GO:0003322) |
| 1.3 | 41.3 | GO:0015988 | energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.9 | 36.6 | GO:0048665 | neuron fate specification(GO:0048665) |
| 1.3 | 33.3 | GO:0032802 | low-density lipoprotein particle receptor catabolic process(GO:0032802) |
| 0.4 | 32.2 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 3.5 | 31.6 | GO:0070315 | G1 to G0 transition involved in cell differentiation(GO:0070315) |
| 0.5 | 30.3 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 3.0 | 29.9 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 9.6 | 28.8 | GO:2000866 | positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866) |
| 2.2 | 28.2 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 67.2 | GO:0005874 | microtubule(GO:0005874) |
| 0.6 | 60.2 | GO:0030315 | T-tubule(GO:0030315) |
| 0.1 | 49.2 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 1.6 | 34.7 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 3.0 | 32.8 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 4.7 | 28.1 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 2.4 | 26.9 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.2 | 25.2 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.1 | 25.2 | GO:0031968 | mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968) |
| 0.7 | 23.5 | GO:0000421 | autophagosome membrane(GO:0000421) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 48.9 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 1.8 | 48.6 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.3 | 41.9 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.6 | 40.5 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.3 | 40.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 39.1 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 35.7 | GO:0045296 | cadherin binding(GO:0045296) |
| 1.5 | 32.2 | GO:0044769 | hydrogen-exporting ATPase activity(GO:0036442) ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.5 | 31.7 | GO:0030507 | spectrin binding(GO:0030507) |
| 1.9 | 31.6 | GO:0031432 | titin binding(GO:0031432) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 44.0 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.9 | 39.6 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.6 | 38.7 | ST ADRENERGIC | Adrenergic Pathway |
| 0.4 | 37.9 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.9 | 33.6 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 1.1 | 30.5 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.8 | 29.6 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.4 | 25.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.4 | 23.0 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.2 | 18.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 52.4 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.8 | 48.5 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 1.3 | 47.8 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.6 | 45.2 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 1.6 | 32.9 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 1.1 | 30.5 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.2 | 27.3 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.8 | 24.7 | REACTOME BOTULINUM NEUROTOXICITY | Genes involved in Botulinum neurotoxicity |
| 0.3 | 21.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.4 | 20.2 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |