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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MEIS3_TGIF2LX
Z-value: 0.72
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Transcription factors associated with MEIS3_TGIF2LX
Network of associatons between targets according to the STRING database.
First level regulatory network of MEIS3_TGIF2LX
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.1 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 0.2 | 11.2 | GO:0071391 | cellular response to estrogen stimulus(GO:0071391) |
| 0.3 | 10.8 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.1 | 10.6 | GO:0005977 | glycogen metabolic process(GO:0005977) |
| 0.6 | 8.8 | GO:0045721 | negative regulation of gluconeogenesis(GO:0045721) |
| 2.9 | 8.6 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) |
| 0.6 | 8.5 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 1.9 | 7.5 | GO:1902283 | negative regulation of primary amine oxidase activity(GO:1902283) |
| 0.0 | 7.3 | GO:0035725 | sodium ion transmembrane transport(GO:0035725) |
| 0.5 | 7.0 | GO:0071313 | cellular response to caffeine(GO:0071313) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 45.1 | GO:0005615 | extracellular space(GO:0005615) |
| 1.2 | 10.8 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.0 | 7.7 | GO:0005911 | cell-cell junction(GO:0005911) |
| 0.3 | 7.3 | GO:0044453 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
| 0.1 | 7.2 | GO:0005902 | microvillus(GO:0005902) |
| 0.4 | 7.0 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.0 | 6.9 | GO:0005929 | cilium(GO:0005929) |
| 0.0 | 5.6 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.0 | 5.4 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.1 | 5.3 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 38.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.0 | 12.2 | GO:0008430 | selenium binding(GO:0008430) |
| 0.1 | 12.1 | GO:0005261 | cation channel activity(GO:0005261) |
| 1.4 | 10.8 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 1.3 | 10.6 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 1.1 | 8.5 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.1 | 8.3 | GO:0005272 | sodium channel activity(GO:0005272) |
| 1.9 | 7.5 | GO:0052594 | tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596) |
| 0.2 | 7.5 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.7 | 7.3 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.7 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 8.5 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 7.2 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 6.6 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 6.1 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.2 | 5.3 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.1 | 5.3 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 5.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 4.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 4.5 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.8 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.5 | 10.6 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 7.9 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.4 | 7.4 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.2 | 6.9 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.5 | 6.6 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.2 | 5.9 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 5.9 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 5.6 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 5.3 | REACTOME G PROTEIN ACTIVATION | Genes involved in G-protein activation |