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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MESP1
Z-value: 1.72
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Transcription factors associated with MESP1
Network of associatons between targets according to the STRING database.
First level regulatory network of MESP1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_116526277 Show fit | 59.79 |
ENST00000393468.1
ENST00000393467.1 |
caveolin 1 |
|
| chr7_+_116525524 Show fit | 54.36 |
ENST00000405348.6
|
caveolin 1 |
|
| chr11_-_65900375 Show fit | 38.62 |
ENST00000312562.7
|
FOS like 1, AP-1 transcription factor subunit |
|
| chr11_-_65900413 Show fit | 35.35 |
ENST00000448083.6
ENST00000531493.5 ENST00000532401.1 |
FOS like 1, AP-1 transcription factor subunit |
|
| chr17_+_41255384 Show fit | 34.42 |
ENST00000394008.1
|
keratin associated protein 9-9 |
|
| chr4_-_156971769 Show fit | 30.12 |
ENST00000502773.6
|
platelet derived growth factor C |
|
| chr3_+_49022077 Show fit | 28.58 |
ENST00000326925.11
|
NADH:ubiquinone oxidoreductase complex assembly factor 3 |
|
| chr7_-_29990113 Show fit | 27.94 |
ENST00000426154.5
ENST00000421434.5 ENST00000434476.6 |
secernin 1 |
|
| chr3_-_149971109 Show fit | 27.15 |
ENST00000239940.11
|
profilin 2 |
|
| chr12_+_52949107 Show fit | 26.84 |
ENST00000388835.4
|
keratin 18 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 126.1 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 28.5 | 114.2 | GO:1903609 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 0.8 | 84.0 | GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418) |
| 2.7 | 74.8 | GO:0034063 | stress granule assembly(GO:0034063) |
| 12.3 | 74.0 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.2 | 73.2 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 1.6 | 67.9 | GO:0097284 | hepatocyte apoptotic process(GO:0097284) |
| 4.8 | 62.8 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 4.8 | 62.7 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 1.4 | 55.6 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.6 | 112.6 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 2.2 | 100.5 | GO:0045095 | keratin filament(GO:0045095) |
| 0.2 | 88.0 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 76.6 | GO:0070062 | extracellular exosome(GO:0070062) |
| 2.6 | 76.0 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 6.4 | 70.3 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.5 | 69.7 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.7 | 67.5 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.6 | 57.1 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.9 | 54.4 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 125.2 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 28.5 | 114.2 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 0.2 | 101.0 | GO:0005525 | GTP binding(GO:0005525) |
| 1.9 | 84.6 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 1.1 | 62.3 | GO:0019894 | kinesin binding(GO:0019894) |
| 2.1 | 61.2 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 1.7 | 59.7 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 1.3 | 57.0 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.7 | 55.9 | GO:0030295 | protein kinase activator activity(GO:0030295) |
| 1.1 | 54.4 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 110.2 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 1.6 | 97.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 1.3 | 85.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.8 | 74.0 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 1.0 | 68.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 1.6 | 60.7 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 1.3 | 55.8 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.8 | 53.2 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.4 | 50.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 1.1 | 43.3 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 125.8 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 4.2 | 108.3 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 3.7 | 87.7 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 1.2 | 85.6 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 1.5 | 81.5 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.8 | 67.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 1.3 | 62.5 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.6 | 62.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.9 | 56.1 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.7 | 53.9 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |