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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MIXL1_GSX1_BSX_MEOX2_LHX4
Z-value: 0.80
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Transcription factors associated with MIXL1_GSX1_BSX_MEOX2_LHX4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000185155.12 | MIXL1 | |
| ENSG00000169840.5 | GSX1 | |
| ENSG00000188909.5 | BSX | |
| ENSG00000106511.6 | MEOX2 | |
| ENSG00000121454.6 | LHX4 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MIXL1 | hg38_v1_chr1_+_226223618_226223670 | 0.20 | 2.4e-03 | Click! |
| MEOX2 | hg38_v1_chr7_-_15686671_15686689 | 0.09 | 2.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MIXL1_GSX1_BSX_MEOX2_LHX4
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_40196907 Show fit | 23.78 |
ENST00000622175.4
ENST00000619474.4 ENST00000615083.4 ENST00000610353.4 ENST00000614836.1 |
ras homolog family member H |
|
| chr4_+_40197023 Show fit | 22.29 |
ENST00000381799.10
|
ras homolog family member H |
|
| chr12_-_14950606 Show fit | 21.89 |
ENST00000536592.5
|
Rho GDP dissociation inhibitor beta |
|
| chr13_-_46142834 Show fit | 18.77 |
ENST00000674665.1
|
lymphocyte cytosolic protein 1 |
|
| chr2_-_157444044 Show fit | 15.89 |
ENST00000264192.8
|
cytohesin 1 interacting protein |
|
| chr2_+_68734773 Show fit | 15.28 |
ENST00000409202.8
|
Rho GTPase activating protein 25 |
|
| chr1_-_92486916 Show fit | 14.24 |
ENST00000294702.6
|
growth factor independent 1 transcriptional repressor |
|
| chr3_-_18438767 Show fit | 14.23 |
ENST00000454909.6
|
SATB homeobox 1 |
|
| chr13_-_41019289 Show fit | 13.94 |
ENST00000239882.7
|
E74 like ETS transcription factor 1 |
|
| chr12_-_91153149 Show fit | 12.88 |
ENST00000550758.1
|
decorin |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 50.2 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.7 | 43.3 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
| 0.2 | 38.1 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 1.1 | 34.0 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 7.3 | 21.9 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 3.3 | 19.9 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 0.2 | 19.4 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 1.4 | 17.7 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.9 | 17.6 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.6 | 16.5 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 80.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.9 | 52.8 | GO:0001772 | immunological synapse(GO:0001772) |
| 1.0 | 24.7 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.8 | 23.9 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.1 | 19.8 | GO:0016363 | nuclear matrix(GO:0016363) |
| 1.5 | 19.7 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 18.3 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.9 | 17.8 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.4 | 16.4 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.4 | 15.4 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 77.0 | GO:0003823 | antigen binding(GO:0003823) |
| 1.7 | 43.3 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.1 | 37.7 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.1 | 35.2 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 2.7 | 21.9 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 1.2 | 20.6 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.7 | 20.5 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.3 | 20.2 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.8 | 17.7 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.2 | 17.5 | GO:0005518 | collagen binding(GO:0005518) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 41.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.4 | 25.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 23.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 21.6 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.3 | 21.3 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.3 | 17.2 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.3 | 15.8 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 14.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 13.9 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 12.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 92.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.9 | 22.0 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.6 | 20.0 | REACTOME DOWNSTREAM TCR SIGNALING | Genes involved in Downstream TCR signaling |
| 0.7 | 16.0 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 16.0 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 1.3 | 14.8 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.2 | 14.1 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 13.7 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.3 | 13.4 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.5 | 12.4 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |