Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for MLXIPL
Z-value: 1.27
Motif logo
Transcription factors associated with MLXIPL
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MLXIPL | hg38_v1_chr7_-_73624492_73624549 | 0.48 | 1.0e-13 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MLXIPL
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 99.9 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 1.1 | 50.3 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.5 | 41.2 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 1.3 | 25.5 | GO:0015671 | oxygen transport(GO:0015671) |
| 6.2 | 24.9 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 1.4 | 22.2 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.1 | 21.6 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.7 | 20.5 | GO:0035428 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
| 2.5 | 19.8 | GO:0051121 | hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122) |
| 3.8 | 19.0 | GO:1902847 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 91.1 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.2 | 31.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.3 | 27.0 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.2 | 26.4 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.8 | 26.2 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 6.3 | 25.3 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 1.7 | 25.3 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.2 | 23.9 | GO:0005796 | Golgi lumen(GO:0005796) |
| 2.4 | 21.3 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.3 | 19.5 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 113.5 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 112.9 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.4 | 66.3 | GO:0003823 | antigen binding(GO:0003823) |
| 0.9 | 57.7 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.8 | 27.7 | GO:0005452 | inorganic anion exchanger activity(GO:0005452) |
| 1.7 | 25.5 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 2.5 | 22.9 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 6.8 | 20.3 | GO:0098519 | nucleotide phosphatase activity, acting on free nucleotides(GO:0098519) |
| 0.2 | 20.2 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.2 | 19.4 | GO:0004497 | monooxygenase activity(GO:0004497) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 47.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 30.7 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.3 | 17.8 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.3 | 17.0 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.7 | 15.2 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.3 | 15.0 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.3 | 11.6 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.3 | 9.8 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.3 | 9.6 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.3 | 8.7 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 151.0 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.9 | 19.4 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 18.1 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.2 | 16.5 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.3 | 14.7 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.6 | 13.4 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.1 | 12.4 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.3 | 12.3 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.6 | 11.7 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 1.0 | 11.5 | REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |