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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MLX_USF2_USF1_PAX2
Z-value: 1.25
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Transcription factors associated with MLX_USF2_USF1_PAX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| USF2 | hg38_v1_chr19_+_35268921_35268988 | 0.30 | 6.5e-06 | Click! |
| MLX | hg38_v1_chr17_+_42567084_42567125 | 0.19 | 4.3e-03 | Click! |
| PAX2 | hg38_v1_chr10_+_100746197_100746220 | 0.07 | 3.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MLX_USF2_USF1_PAX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 80.0 | GO:0043312 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 5.4 | 54.5 | GO:1904715 | negative regulation of chaperone-mediated autophagy(GO:1904715) |
| 1.6 | 53.6 | GO:0090383 | phagosome acidification(GO:0090383) |
| 6.8 | 47.5 | GO:1902962 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
| 5.2 | 41.7 | GO:1900113 | negative regulation of histone H3-K9 trimethylation(GO:1900113) |
| 13.6 | 40.9 | GO:0070429 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) |
| 2.2 | 34.6 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.5 | 33.6 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.2 | 29.5 | GO:0030183 | B cell differentiation(GO:0030183) |
| 3.1 | 27.6 | GO:0098535 | de novo centriole assembly(GO:0098535) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 125.4 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.2 | 100.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.3 | 83.7 | GO:0000323 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.6 | 71.8 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.5 | 57.8 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 6.9 | 55.4 | GO:0098575 | lumenal side of lysosomal membrane(GO:0098575) |
| 4.0 | 47.7 | GO:0071203 | WASH complex(GO:0071203) |
| 0.5 | 47.4 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.6 | 45.3 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.3 | 41.7 | GO:0016605 | PML body(GO:0016605) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 99.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.8 | 66.0 | GO:0005507 | copper ion binding(GO:0005507) |
| 6.8 | 54.4 | GO:0004308 | exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) |
| 3.6 | 49.9 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 1.8 | 37.0 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 2.6 | 35.8 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 2.6 | 35.8 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 1.6 | 34.5 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 1.5 | 34.1 | GO:0044769 | hydrogen-exporting ATPase activity(GO:0036442) ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.2 | 33.7 | GO:0000149 | SNARE binding(GO:0000149) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 61.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.9 | 44.7 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.3 | 39.3 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.6 | 29.9 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.6 | 29.5 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.6 | 29.5 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.3 | 27.9 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.5 | 27.2 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.2 | 25.6 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.6 | 24.9 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 94.3 | REACTOME TRANS GOLGI NETWORK VESICLE BUDDING | Genes involved in trans-Golgi Network Vesicle Budding |
| 2.0 | 60.2 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.8 | 48.9 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.2 | 45.4 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.9 | 42.7 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.5 | 41.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.2 | 36.5 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 1.8 | 27.0 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 1.2 | 23.2 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 3.5 | 20.9 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |