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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MNT_HEY1_HEY2
Z-value: 1.83
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Transcription factors associated with MNT_HEY1_HEY2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HEY2 | hg38_v1_chr6_+_125749623_125749655 | 0.56 | 3.5e-19 | Click! |
| HEY1 | hg38_v1_chr8_-_79767462_79767776, hg38_v1_chr8_-_79767843_79767867 | 0.28 | 3.5e-05 | Click! |
| MNT | hg38_v1_chr17_-_2401038_2401104 | -0.11 | 1.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MNT_HEY1_HEY2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_154220533 Show fit | 74.53 |
ENST00000368518.5
ENST00000368519.5 ENST00000368521.10 |
chromosome 1 open reading frame 43 |
|
| chrX_-_13938378 Show fit | 70.22 |
ENST00000398361.7
|
glycoprotein M6B |
|
| chr1_-_11805977 Show fit | 69.19 |
ENST00000376486.3
|
methylenetetrahydrofolate reductase |
|
| chr1_+_11806096 Show fit | 63.95 |
ENST00000312413.10
ENST00000346436.11 |
chloride voltage-gated channel 6 |
|
| chrX_-_13938618 Show fit | 60.11 |
ENST00000454189.6
|
glycoprotein M6B |
|
| chr5_-_131796921 Show fit | 56.97 |
ENST00000307968.11
ENST00000307954.12 |
folliculin interacting protein 1 |
|
| chr1_-_11805949 Show fit | 56.58 |
ENST00000376590.9
|
methylenetetrahydrofolate reductase |
|
| chr1_-_11805924 Show fit | 56.15 |
ENST00000418034.1
|
methylenetetrahydrofolate reductase |
|
| chr1_-_241357225 Show fit | 55.57 |
ENST00000366565.5
|
regulator of G protein signaling 7 |
|
| chr17_-_7916280 Show fit | 54.37 |
ENST00000324348.9
|
ring finger protein 227 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 271.3 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 30.3 | 181.9 | GO:0070829 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
| 12.5 | 150.1 | GO:0051612 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 27.5 | 137.7 | GO:0002904 | positive regulation of B cell apoptotic process(GO:0002904) |
| 5.6 | 100.6 | GO:0050812 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812) |
| 4.6 | 92.7 | GO:0051823 | regulation of synapse structural plasticity(GO:0051823) |
| 8.3 | 91.7 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 8.4 | 84.2 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 11.3 | 79.3 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 26.0 | 78.0 | GO:0097477 | spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 210.2 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.2 | 135.3 | GO:0045202 | synapse(GO:0045202) |
| 8.0 | 80.2 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
| 0.2 | 79.1 | GO:0036477 | somatodendritic compartment(GO:0036477) |
| 0.6 | 78.4 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 1.3 | 76.1 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 3.0 | 65.8 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.5 | 62.1 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.4 | 57.5 | GO:0032587 | ruffle membrane(GO:0032587) |
| 1.0 | 54.5 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 196.5 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 30.3 | 181.9 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 11.8 | 153.4 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 2.7 | 134.7 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 6.3 | 132.2 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 32.9 | 131.7 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.4 | 126.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.7 | 119.1 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 3.9 | 94.2 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 2.4 | 81.0 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 132.1 | PID REELIN PATHWAY | Reelin signaling pathway |
| 2.6 | 110.8 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.7 | 87.3 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 1.3 | 72.2 | PID AURORA A PATHWAY | Aurora A signaling |
| 1.1 | 64.8 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.8 | 55.4 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 1.3 | 52.9 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 1.2 | 51.1 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.7 | 43.4 | PID BMP PATHWAY | BMP receptor signaling |
| 1.0 | 43.0 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 228.2 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 4.4 | 141.7 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 1.8 | 133.7 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 5.9 | 100.6 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.6 | 84.1 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.8 | 73.5 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 3.0 | 68.4 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.3 | 62.7 | REACTOME TRANSCRIPTION | Genes involved in Transcription |
| 1.1 | 58.4 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 2.3 | 53.3 | REACTOME ACYL CHAIN REMODELLING OF PE | Genes involved in Acyl chain remodelling of PE |