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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MSX1
Z-value: 0.71
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Transcription factors associated with MSX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MSX1 | hg38_v1_chr4_+_4859658_4859672 | 0.00 | 9.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MSX1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.2 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 3.8 | 19.1 | GO:1904207 | regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 2.6 | 15.7 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 2.1 | 12.8 | GO:0046092 | deoxycytidine metabolic process(GO:0046092) |
| 0.9 | 12.3 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) |
| 4.1 | 12.2 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) |
| 0.1 | 10.2 | GO:0034446 | substrate adhesion-dependent cell spreading(GO:0034446) |
| 0.8 | 9.8 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 0.4 | 9.6 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.6 | 7.9 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 20.7 | GO:0044429 | mitochondrial part(GO:0044429) |
| 0.0 | 19.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 19.1 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.2 | 15.7 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 11.7 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 9.6 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 8.8 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 7.9 | GO:0030424 | axon(GO:0030424) |
| 0.9 | 7.5 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 2.2 | 6.7 | GO:0043159 | acrosomal matrix(GO:0043159) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.2 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.1 | 17.9 | GO:0008201 | heparin binding(GO:0008201) |
| 3.9 | 15.7 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 1.8 | 12.8 | GO:0004797 | deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797) |
| 1.0 | 12.2 | GO:0008430 | selenium binding(GO:0008430) |
| 0.1 | 10.2 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.5 | 9.8 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.3 | 9.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.3 | 7.5 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 2.2 | 6.7 | GO:0004040 | amidase activity(GO:0004040) fucose binding(GO:0042806) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 23.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 15.7 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.3 | 9.6 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 9.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 7.5 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 4.2 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 4.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 3.9 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 3.8 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 3.1 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.3 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.3 | 15.7 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.4 | 12.8 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.4 | 9.6 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.2 | 5.4 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.2 | 4.0 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.1 | 3.9 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.1 | 3.7 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.3 | 3.4 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 3.1 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |