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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MSX2
Z-value: 0.54
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Transcription factors associated with MSX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MSX2 | hg38_v1_chr5_+_174724549_174724607 | 0.04 | 5.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MSX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 30.7 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 0.7 | 27.6 | GO:0007094 | mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173) |
| 7.2 | 21.5 | GO:0009786 | regulation of asymmetric cell division(GO:0009786) |
| 5.6 | 16.8 | GO:0008614 | pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 biosynthetic process(GO:0042819) |
| 3.6 | 10.7 | GO:0007057 | spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195) |
| 0.7 | 8.8 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
| 0.3 | 8.0 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.1 | 7.9 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 0.8 | 7.1 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.1 | 7.0 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 32.2 | GO:0072687 | meiotic spindle(GO:0072687) |
| 6.0 | 18.1 | GO:1990298 | mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298) |
| 0.3 | 9.5 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.1 | 9.3 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 8.0 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 7.4 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.1 | 7.0 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.0 | 6.8 | GO:0030496 | midbody(GO:0030496) |
| 0.7 | 6.6 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 6.5 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 30.7 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 0.1 | 18.1 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.1 | 15.9 | GO:0005516 | calmodulin binding(GO:0005516) |
| 1.2 | 10.7 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 0.4 | 10.5 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.0 | 7.9 | GO:0051015 | actin filament binding(GO:0051015) |
| 2.4 | 7.1 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
| 0.0 | 6.9 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.1 | 6.8 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 6.1 | GO:0044325 | ion channel binding(GO:0044325) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.1 | PID P73PATHWAY | p73 transcription factor network |
| 0.2 | 10.7 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 8.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 7.9 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 7.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 7.0 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 3.3 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 2.9 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 2.7 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.6 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 18.1 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.6 | 16.8 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.2 | 14.3 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.2 | 5.1 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.1 | 4.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 4.6 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 4.0 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 3.4 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.1 | 2.6 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.1 | 2.4 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |