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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MXI1_MYC_MYCN
Z-value: 4.17
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Transcription factors associated with MXI1_MYC_MYCN
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYC | hg38_v1_chr8_+_127737610_127737626, hg38_v1_chr8_+_127736220_127736241, hg38_v1_chr8_+_127735597_127735659, hg38_v1_chr8_+_127736046_127736084 | 0.80 | 1.1e-49 | Click! |
| MYCN | hg38_v1_chr2_+_15940537_15940566 | -0.59 | 3.7e-22 | Click! |
| MXI1 | hg38_v1_chr10_+_110207587_110207684, hg38_v1_chr10_+_110225955_110226016 | -0.36 | 4.0e-08 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MXI1_MYC_MYCN
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_10448318 Show fit | 235.67 |
ENST00000234111.9
|
ornithine decarboxylase 1 |
|
| chr12_-_57752265 Show fit | 214.62 |
ENST00000547281.5
ENST00000257904.11 ENST00000546489.5 ENST00000552388.1 |
cyclin dependent kinase 4 |
|
| chr12_-_57752345 Show fit | 209.28 |
ENST00000551800.5
ENST00000549606.5 ENST00000312990.10 |
cyclin dependent kinase 4 |
|
| chr11_-_64246907 Show fit | 200.07 |
ENST00000309318.8
|
protein phosphatase 1 regulatory inhibitor subunit 14B |
|
| chr17_+_51153551 Show fit | 154.28 |
ENST00000393196.8
ENST00000336097.7 ENST00000480143.5 ENST00000511355.5 ENST00000393193.6 ENST00000376392.10 |
NME/NM23 nucleoside diphosphate kinase 1 NME1-NME2 readthrough |
|
| chr2_+_215312028 Show fit | 151.84 |
ENST00000236959.14
ENST00000435675.5 |
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase |
|
| chr4_+_56435730 Show fit | 151.59 |
ENST00000514888.5
ENST00000264221.6 ENST00000505164.5 |
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase |
|
| chr4_+_56436131 Show fit | 147.67 |
ENST00000399688.7
|
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase |
|
| chr19_+_49677055 Show fit | 147.13 |
ENST00000534465.6
ENST00000391851.8 ENST00000610806.4 |
protein arginine methyltransferase 1 |
|
| chrX_+_23667461 Show fit | 144.34 |
ENST00000379341.9
ENST00000379331.3 |
peroxiredoxin 4 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 856.9 | GO:0006364 | rRNA processing(GO:0006364) |
| 7.6 | 634.9 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 52.1 | 521.0 | GO:0006189 | 'de novo' IMP biosynthetic process(GO:0006189) |
| 5.0 | 461.3 | GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) |
| 84.8 | 423.9 | GO:1904636 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
| 5.5 | 409.4 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 44.7 | 402.4 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 27.3 | 381.5 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 66.3 | 331.6 | GO:0033387 | putrescine biosynthetic process from ornithine(GO:0033387) |
| 53.0 | 318.1 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2522.9 | GO:0070062 | extracellular exosome(GO:0070062) |
| 3.2 | 580.5 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 2.4 | 532.6 | GO:0031968 | organelle outer membrane(GO:0031968) |
| 4.6 | 468.8 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 0.6 | 458.5 | GO:0005730 | nucleolus(GO:0005730) |
| 69.7 | 418.4 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 11.8 | 389.2 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 7.8 | 372.0 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 24.4 | 365.5 | GO:0034709 | methylosome(GO:0034709) |
| 31.3 | 344.2 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 829.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 14.2 | 555.3 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 27.4 | 521.4 | GO:0019215 | intermediate filament binding(GO:0019215) |
| 5.9 | 395.5 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 10.9 | 391.8 | GO:0008143 | poly(A) binding(GO:0008143) |
| 7.8 | 382.2 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 3.5 | 371.4 | GO:0008565 | protein transporter activity(GO:0008565) |
| 7.7 | 362.1 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 1.0 | 347.8 | GO:0045296 | cadherin binding(GO:0045296) |
| 2.8 | 318.3 | GO:0051082 | unfolded protein binding(GO:0051082) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.7 | 1951.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 22.7 | 453.7 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 5.1 | 450.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 2.4 | 413.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 7.0 | 351.1 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 3.2 | 301.1 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 15.6 | 296.9 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 2.4 | 204.5 | PID E2F PATHWAY | E2F transcription factor network |
| 3.7 | 180.3 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 2.4 | 164.4 | PID RAC1 PATHWAY | RAC1 signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.5 | 855.8 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 7.1 | 645.3 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 37.7 | 565.1 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 16.8 | 553.5 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 25.9 | 518.7 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 4.3 | 511.3 | REACTOME INFLUENZA LIFE CYCLE | Genes involved in Influenza Life Cycle |
| 3.9 | 505.6 | REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | Genes involved in Processing of Capped Intron-Containing Pre-mRNA |
| 8.4 | 477.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 5.7 | 434.1 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 10.8 | 389.7 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |