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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MYB
Z-value: 3.57
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Transcription factors associated with MYB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYB | hg38_v1_chr6_+_135181268_135181322 | 0.33 | 7.5e-07 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MYB
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 376.0 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 22.4 | 291.7 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 4.7 | 217.2 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 8.2 | 180.4 | GO:0007064 | mitotic sister chromatid cohesion(GO:0007064) |
| 2.2 | 160.8 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 38.9 | 155.6 | GO:1904045 | cellular response to aldosterone(GO:1904045) |
| 4.1 | 140.2 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 31.3 | 125.1 | GO:0071733 | transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579) |
| 1.2 | 107.6 | GO:0070671 | interleukin-12-mediated signaling pathway(GO:0035722) response to interleukin-12(GO:0070671) cellular response to interleukin-12(GO:0071349) |
| 1.7 | 107.4 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 300.6 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 11.2 | 280.7 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 23.3 | 256.6 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 2.0 | 218.8 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 177.5 | GO:0070062 | extracellular exosome(GO:0070062) |
| 9.4 | 151.0 | GO:0005642 | annulate lamellae(GO:0005642) |
| 1.3 | 147.2 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.4 | 143.7 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 4.9 | 141.3 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 12.5 | 125.1 | GO:0097255 | R2TP complex(GO:0097255) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.6 | 321.4 | GO:0008494 | translation activator activity(GO:0008494) |
| 5.1 | 293.0 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.2 | 259.5 | GO:0003723 | RNA binding(GO:0003723) |
| 13.0 | 155.6 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.7 | 139.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 2.9 | 134.8 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 18.4 | 128.8 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 25.0 | 125.1 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
| 2.8 | 123.8 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 6.1 | 122.1 | GO:0017070 | U6 snRNA binding(GO:0017070) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 318.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.9 | 166.5 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 3.9 | 154.4 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 2.9 | 142.6 | PID MYC PATHWAY | C-MYC pathway |
| 2.3 | 136.1 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 1.8 | 86.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.0 | 66.0 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 1.8 | 62.1 | PID ATM PATHWAY | ATM pathway |
| 1.8 | 59.0 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 2.0 | 58.8 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.4 | 304.0 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 2.0 | 180.1 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 5.3 | 175.8 | REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | Genes involved in APC-Cdc20 mediated degradation of Nek2A |
| 0.9 | 157.2 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 1.7 | 141.9 | REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 | Genes involved in SCF(Skp2)-mediated degradation of p27/p21 |
| 3.5 | 133.8 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 1.0 | 111.9 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 2.2 | 95.4 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.5 | 75.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 4.9 | 73.9 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |