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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MYBL2
Z-value: 2.13
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Transcription factors associated with MYBL2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYBL2 | hg38_v1_chr20_+_43667019_43667098, hg38_v1_chr20_+_43667105_43667125 | 0.46 | 1.2e-12 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MYBL2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 306.2 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 1.4 | 83.8 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 2.3 | 79.9 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.8 | 78.1 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.8 | 58.4 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 1.6 | 54.1 | GO:2000816 | negative regulation of mitotic sister chromatid separation(GO:2000816) |
| 2.8 | 50.7 | GO:0000022 | mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231) |
| 4.3 | 46.9 | GO:0000712 | resolution of meiotic recombination intermediates(GO:0000712) |
| 2.7 | 46.4 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 3.4 | 44.5 | GO:0000972 | transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 216.0 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.6 | 119.1 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 7.4 | 80.9 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.7 | 80.8 | GO:0005643 | nuclear pore(GO:0005643) |
| 8.9 | 80.1 | GO:0072687 | meiotic spindle(GO:0072687) |
| 2.7 | 77.6 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 1.7 | 61.5 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 1.8 | 55.4 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
| 3.9 | 55.1 | GO:0070938 | contractile ring(GO:0070938) |
| 2.1 | 49.9 | GO:0070822 | Sin3-type complex(GO:0070822) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 208.1 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.6 | 73.4 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 1.5 | 69.9 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.9 | 62.3 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 1.3 | 60.3 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.7 | 58.5 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 6.8 | 54.4 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.8 | 50.7 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.2 | 50.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 7.0 | 49.1 | GO:0004457 | lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 131.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.4 | 90.2 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.7 | 67.1 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 1.2 | 58.3 | PID MYC PATHWAY | C-MYC pathway |
| 0.5 | 47.7 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.3 | 36.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 34.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.4 | 28.9 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 27.1 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.3 | 27.0 | PID E2F PATHWAY | E2F transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 178.2 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.5 | 87.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 1.1 | 72.0 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 1.7 | 62.3 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.7 | 59.2 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.5 | 41.3 | REACTOME KINESINS | Genes involved in Kinesins |
| 3.1 | 34.3 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 1.0 | 33.7 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.8 | 30.8 | REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | Genes involved in Activation of ATR in response to replication stress |
| 0.4 | 30.6 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |