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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MYF6
Z-value: 1.26
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Transcription factors associated with MYF6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYF6 | hg38_v1_chr12_+_80707625_80707642 | 0.25 | 1.4e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MYF6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 71.5 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 1.9 | 32.1 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 1.9 | 30.4 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
| 2.1 | 25.1 | GO:0008354 | germ cell migration(GO:0008354) |
| 0.2 | 25.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 1.2 | 24.7 | GO:0051823 | regulation of synapse structural plasticity(GO:0051823) |
| 7.5 | 22.6 | GO:1904397 | negative regulation of neuromuscular junction development(GO:1904397) |
| 4.1 | 20.3 | GO:0015688 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 1.9 | 19.5 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 1.2 | 18.5 | GO:0007258 | JUN phosphorylation(GO:0007258) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 104.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 84.8 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 2.4 | 38.6 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.2 | 37.2 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.1 | 32.8 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.5 | 32.3 | GO:0005844 | polysome(GO:0005844) |
| 0.1 | 30.1 | GO:0031301 | integral component of organelle membrane(GO:0031301) |
| 0.3 | 24.6 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.1 | 24.0 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.9 | 23.5 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 76.2 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 1.3 | 38.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.6 | 35.0 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.3 | 34.6 | GO:0005518 | collagen binding(GO:0005518) |
| 1.4 | 29.8 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.2 | 29.3 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 27.5 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 4.2 | 25.1 | GO:0042392 | sphingosine-1-phosphate phosphatase activity(GO:0042392) |
| 0.4 | 22.4 | GO:0030507 | spectrin binding(GO:0030507) |
| 5.1 | 20.6 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 77.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.8 | 43.7 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.9 | 42.1 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 40.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 24.5 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.6 | 21.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.8 | 20.1 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.5 | 19.5 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 17.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 17.0 | ST ADRENERGIC | Adrenergic Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 59.3 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.6 | 38.4 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 32.6 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 23.1 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.7 | 22.4 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.8 | 20.4 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.7 | 18.3 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.5 | 17.4 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.7 | 13.9 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.1 | 13.7 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |