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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MYOD1
Z-value: 1.42
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Transcription factors associated with MYOD1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYOD1 | hg38_v1_chr11_+_17719564_17719577 | 0.54 | 1.2e-17 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MYOD1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 137.0 | GO:0033275 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 14.6 | 87.6 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
| 4.8 | 38.2 | GO:0070236 | regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 12.5 | 37.5 | GO:0001869 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 1.9 | 28.9 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 3.0 | 27.0 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.2 | 25.2 | GO:0007519 | skeletal muscle tissue development(GO:0007519) |
| 5.7 | 22.9 | GO:0090299 | fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314) |
| 2.8 | 22.8 | GO:0010936 | negative regulation of macrophage cytokine production(GO:0010936) |
| 0.2 | 22.6 | GO:0051291 | protein heterooligomerization(GO:0051291) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.9 | 87.6 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 3.2 | 66.4 | GO:0005861 | troponin complex(GO:0005861) |
| 0.5 | 61.0 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 1.5 | 58.8 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 3.6 | 49.7 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 2.4 | 28.2 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 3.4 | 27.2 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.5 | 21.8 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.2 | 20.5 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.1 | 18.9 | GO:0031674 | I band(GO:0031674) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 105.9 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 3.4 | 48.2 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.7 | 42.7 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.2 | 39.6 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 4.2 | 38.2 | GO:0043426 | MRF binding(GO:0043426) |
| 0.3 | 37.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 33.1 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.2 | 28.3 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 25.9 | GO:0004386 | helicase activity(GO:0004386) |
| 0.1 | 22.8 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 50.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.9 | 40.5 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.2 | 33.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 24.3 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.9 | 20.3 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 18.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 12.5 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.2 | 12.3 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.4 | 11.1 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.3 | 11.1 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 159.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 1.6 | 37.5 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 1.0 | 28.3 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.8 | 26.4 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.3 | 22.3 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.6 | 19.9 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.3 | 16.5 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.4 | 16.2 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.3 | 16.1 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.7 | 15.6 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |